BUB2_DICDI
ID BUB2_DICDI Reviewed; 366 AA.
AC Q55EP9;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Putative mitotic check point protein BUB2;
GN Name=bub2; ORFNames=DDB_G0268794;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Part of a checkpoint which monitors spindle integrity and
CC prevents premature exit from mitosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BUB2 family. {ECO:0000305}.
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DR EMBL; AAFI02000004; EAL72986.1; -; Genomic_DNA.
DR RefSeq; XP_646971.1; XM_641879.1.
DR AlphaFoldDB; Q55EP9; -.
DR SMR; Q55EP9; -.
DR STRING; 44689.DDB0232237; -.
DR PaxDb; Q55EP9; -.
DR EnsemblProtists; EAL72986; EAL72986; DDB_G0268794.
DR GeneID; 8616663; -.
DR KEGG; ddi:DDB_G0268794; -.
DR dictyBase; DDB_G0268794; bub2.
DR eggNOG; KOG2058; Eukaryota.
DR HOGENOM; CLU_029367_2_0_1; -.
DR InParanoid; Q55EP9; -.
DR OMA; RVNGWQS; -.
DR PhylomeDB; Q55EP9; -.
DR PRO; PR:Q55EP9; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW Reference proteome.
FT CHAIN 1..366
FT /note="Putative mitotic check point protein BUB2"
FT /id="PRO_0000365596"
FT DOMAIN 63..244
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT REGION 314..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 42047 MW; DBEE393E3B39D8C2 CRC64;
MVIKDLSPHN NSLRKKYLDL IDYGNKNPLT VDPNLYQLRK TILLEGLPPE TEEEIEDRTK
QDGSKCSLRG MIWKILLGVD KIQPDKYIEL IEKGPSNRYQ KIRKDIGRTF NRDSQFSQAV
SQDQLSRCLN AFAHQCEELG YVQGMNAICG TFLYVLPEVE AFQCFYSLLT QCCPNYFTSN
ISGVNDASKL LDRILEFVDP ELYEYLQNRS YHPLLFTPPI LSLGTATPPL DELLKLWDFF
LAFGFHLNVI CTISQILLMR DVLLVHQSPC LLFRSFPELD APTIINLSIH IIRQLPDDIY
DLLVDHPMTS VDLTPFDRDP NNLNSFNGSG EFDNDNDNDN GNQDEEDDDD DDIDDGHNDY
FNDNDE
