ID   TRADD_DANRE             Reviewed;         293 AA.
AC   Q9I9N5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000305};
DE            Short=TNFR1-associated DEATH domain protein {ECO:0000250|UniProtKB:Q15628};
DE   AltName: Full=TNFRSF1A-associated via death domain protein {ECO:0000250|UniProtKB:Q15628};
GN   Name=tradd {ECO:0000312|ZFIN:ZDB-GENE-000511-5};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAF66959.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10917738; DOI=10.1038/sj.cdd.4400679;
RA   Inohara N., Nunez G.;
RT   "Genes with homology to mammalian apoptosis regulators identified in
RT   zebrafish.";
RL   Cell Death Differ. 7:509-510(2000).
RN   [2] {ECO:0000312|EMBL:AAH83425.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary {ECO:0000312|EMBL:AAH83425.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter molecule for tnfrsf1a that specifically associates
CC       with the cytoplasmic domain of activated tnfrsf1a mediating its
CC       interaction with fadd. {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SUBUNIT: Heterodimer with tnfrsf1a. {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3U0V2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q15628}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q15628}. Note=Shuttles between the cytoplasm and
CC       the nucleus. {ECO:0000250|UniProtKB:Q3U0V2}.
CC   -!- DOMAIN: Requires the intact death domain to associate with tnfrsf1a.
CC       {ECO:0000250|UniProtKB:Q15628}.
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DR   EMBL; AF231014; AAF66959.1; -; Genomic_DNA.
DR   EMBL; BC083425; AAH83425.1; -; mRNA.
DR   RefSeq; NP_571682.1; NM_131607.2.
DR   AlphaFoldDB; Q9I9N5; -.
DR   SMR; Q9I9N5; -.
DR   STRING; 7955.ENSDARP00000052344; -.
DR   PaxDb; Q9I9N5; -.
DR   Ensembl; ENSDART00000052345; ENSDARP00000052344; ENSDARG00000036057.
DR   Ensembl; ENSDART00000181954; ENSDARP00000153680; ENSDARG00000117083.
DR   GeneID; 58130; -.
DR   KEGG; dre:58130; -.
DR   CTD; 8717; -.
DR   ZFIN; ZDB-GENE-000511-5; tradd.
DR   eggNOG; ENOG502RXWE; Eukaryota.
DR   GeneTree; ENSGT00390000002016; -.
DR   HOGENOM; CLU_052183_0_0_1; -.
DR   InParanoid; Q9I9N5; -.
DR   OMA; QPCSRFL; -.
DR   OrthoDB; 1024816at2759; -.
DR   PhylomeDB; Q9I9N5; -.
DR   TreeFam; TF331882; -.
DR   Reactome; R-DRE-3371378; Regulation by c-FLIP.
DR   Reactome; R-DRE-5218900; CASP8 activity is inhibited.
DR   Reactome; R-DRE-5357786; TNFR1-induced proapoptotic signaling.
DR   Reactome; R-DRE-5357905; Regulation of TNFR1 signaling.
DR   Reactome; R-DRE-5357956; TNFR1-induced NFkappaB signaling pathway.
DR   Reactome; R-DRE-5675482; Regulation of necroptotic cell death.
DR   Reactome; R-DRE-69416; Dimerization of procaspase-8.
DR   Reactome; R-DRE-75893; TNF signaling.
DR   PRO; PR:Q9I9N5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036057; Expressed in tail and 22 other tissues.
DR   ExpressionAtlas; Q9I9N5; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0002947; C:tumor necrosis factor receptor superfamily complex; IBA:GO_Central.
DR   GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IBA:GO_Central.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IDA:ZFIN.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.30.70.680; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR035712; TRADD.
DR   InterPro; IPR009095; TRADD_N.
DR   InterPro; IPR036729; TRADD_N_sf.
DR   PANTHER; PTHR14913; PTHR14913; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF09034; TRADD_N; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF55044; SSF55044; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..293
FT                   /note="Tumor necrosis factor receptor type 1-associated
FT                   DEATH domain protein"
FT                   /id="PRO_0000291659"
FT   DOMAIN          200..290
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   MOTIF           156..171
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U0V2"
FT   MOTIF           216..229
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U0V2"
SQ   SEQUENCE   293 AA;  33151 MW;  5B797643D1CE2DC7 CRC64;
     MDSIDTKRLN DSNASDRALS GCAVLFLGCS SLEHNFLSLY KDERGKFSVF KVIKLTLSDS
     VGGLEGYEIL KLHDADPYLG VELKFMAMPP CQRFLESYAC GSLTQFLSQH ASRLLALPDG
     VEIETQLKAG VHTLDHSLQD IEICLDHIRQ SQPVRLRDDE VTQLEQQLQN SYGPPSQPPQ
     ELPRNCFLFQ KRVFDDRPLT PADQQRFAAH VGRDWKRVGR ALQKNCRALK GPAIDNLAYE
     YEREGLYEQA YQLLGRFIQS EGRSAKLSRL ISALEETKMT SMAEIMLGIQ PRD