ID   TRADD_ONCMY             Reviewed;         292 AA.
AC   Q1M161;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein;
DE            Short=TNFR1-associated DEATH domain protein;
DE   AltName: Full=TNFRSF1A-associated via death domain protein;
GN   Name=tradd;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1] {ECO:0000312|EMBL:AAU81663.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Macrophage {ECO:0000269|PubMed:15482855};
RX   PubMed=15482855; DOI=10.1016/j.molimm.2004.06.005;
RA   Goetz F.W., Iliev D.B., McCauley L.A., Liarte C.Q., Tort L.B., Planas J.V.,
RA   Mackenzie S.;
RT   "Analysis of genes isolated from lipopolysaccharide-stimulated rainbow
RT   trout (Oncorhynchus mykiss) macrophages.";
RL   Mol. Immunol. 41:1199-1210(2004).
CC   -!- FUNCTION: Adapter molecule for tnfrsf1a that specifically associates
CC       with the cytoplasmic domain of activated tnfrsf1a mediating its
CC       interaction with fadd. {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SUBUNIT: Heterodimer with tnfrsf1a. {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3U0V2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q15628}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q15628}. Note=Shuttles between the cytoplasm and
CC       the nucleus. {ECO:0000250|UniProtKB:Q3U0V2}.
CC   -!- DOMAIN: Requires the intact death domain to associate with tnfrsf1a.
CC       {ECO:0000250|UniProtKB:Q15628}.
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DR   EMBL; AY614596; AAU81663.1; -; mRNA.
DR   RefSeq; NP_001118111.1; NM_001124639.1.
DR   AlphaFoldDB; Q1M161; -.
DR   SMR; Q1M161; -.
DR   GeneID; 100136668; -.
DR   KEGG; omy:100136668; -.
DR   CTD; 8717; -.
DR   OrthoDB; 1024816at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.30.70.680; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR035712; TRADD.
DR   InterPro; IPR009095; TRADD_N.
DR   InterPro; IPR036729; TRADD_N_sf.
DR   PANTHER; PTHR14913; PTHR14913; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF09034; TRADD_N; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF55044; SSF55044; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Cytoskeleton; Nucleus.
FT   CHAIN           1..292
FT                   /note="Tumor necrosis factor receptor type 1-associated
FT                   DEATH domain protein"
FT                   /id="PRO_0000291661"
FT   DOMAIN          199..289
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   MOTIF           148..164
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           215..228
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   292 AA;  32697 MW;  633A27BEFEA7EC86 CRC64;
     MVALSVEVGP WTGCAVLFLR SCPAVNLLSL YKDQQGKFSV FKVLKLTLTD SAGGLEGYEI
     LKLHDADPLL GVEVKFVDVA ACRRFLQSYG SGAVQQSLSQ HTCRLLHIPQ QELALETQLK
     AGTHTLDFCL DDLELCLQHI HQSQPERLRD DEIAELDQQL QSQALGHIPQ PPTLTQEEPP
     VPSNCFLFQK RVFEDRMLAA GDLQRFSNGV GRDWRKVGRA LGKNCRALKG PAIDNLAYEY
     EREGLYEQAY QLLSRFIQAE GRAARLGRLV RALEDSKLTS LAENILDIQP RD