ID   TRADD_XENLA             Reviewed;         303 AA.
AC   Q32NG6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000305};
DE            Short=TNFR1-associated DEATH domain protein {ECO:0000250|UniProtKB:Q15628};
DE   AltName: Full=TNFRSF1A-associated via death domain {ECO:0000250|UniProtKB:Q15628};
GN   Name=tradd {ECO:0000250|UniProtKB:Q15628};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:AAI08638.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter molecule for tnfrsf1a that specifically associates
CC       with the cytoplasmic domain of activated tnfrsf1a mediating its
CC       interaction with fadd. {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SUBUNIT: Heterodimer with tnfrsf1a. {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3U0V2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q15628}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q15628}. Note=Shuttles between the cytoplasm and
CC       the nucleus. {ECO:0000250|UniProtKB:Q3U0V2}.
CC   -!- DOMAIN: Requires the intact death domain to associate with tnfrsf1a.
CC       {ECO:0000250|UniProtKB:Q15628}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI08638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC108637; AAI08638.1; ALT_INIT; mRNA.
DR   RefSeq; XP_018113350.1; XM_018257861.1.
DR   RefSeq; XP_018113351.1; XM_018257862.1.
DR   RefSeq; XP_018113352.1; XM_018257863.1.
DR   AlphaFoldDB; Q32NG6; -.
DR   SMR; Q32NG6; -.
DR   IntAct; Q32NG6; 1.
DR   GeneID; 733418; -.
DR   KEGG; xla:733418; -.
DR   CTD; 733418; -.
DR   Xenbase; XB-GENE-989569; tradd.L.
DR   OMA; QPCSRFL; -.
DR   OrthoDB; 1024816at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 733418; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.30.70.680; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR035712; TRADD.
DR   InterPro; IPR009095; TRADD_N.
DR   InterPro; IPR036729; TRADD_N_sf.
DR   PANTHER; PTHR14913; PTHR14913; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF09034; TRADD_N; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF55044; SSF55044; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Tumor necrosis factor receptor type 1-associated
FT                   DEATH domain protein"
FT                   /id="PRO_0000291662"
FT   DOMAIN          208..298
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   MOTIF           141..157
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U0V2"
FT   MOTIF           224..237
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U0V2"
SQ   SEQUENCE   303 AA;  34377 MW;  F2F92BD8020F98C5 CRC64;
     MAAGPSMWVG SVYLYIKSDT VPLPGKYTHQ KALIYEALRS AISESTRGCR DSIEILKIHS
     SDQQLILYLK FCGLEPCQRF LKDYKECKVQ MQIQNKLKNC FSVEGLPIFT ELKIDTGEID
     SLLEKEEQCL KYISQMKPTI QKDDELAEID ERLKSIKLDS PSALDSELSL QNSCQCSLPL
     SLHSNRSYHI EGSTFHFQGE EFVDRPLTSA HIQHFAKSVG KNWKPVGRSL GKTCRALNDT
     AIENLAYEFD RDGRYEQAYQ LLRLFKDSEG KKATVQRLVQ ALEENGLNSI ALDLLSLNEN
     GLK