ID   TRAR_AGRFC              Reviewed;         234 AA.
AC   P54294;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Transcriptional activator protein TraR;
GN   Name=traR; OrderedLocusNames=Atu6134; ORFNames=AGR_pTi_249;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OG   Plasmid pTiC58.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8464476; DOI=10.1038/362448a0;
RA   Piper K.R., von Bodman S.B., Farrand S.K.;
RT   "Conjugation factor of Agrobacterium tumefaciens regulates Ti plasmid
RT   transfer by autoinduction.";
RL   Nature 362:448-450(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: Positive regulation of conjugal transfer of Ti plasmids. TraR
CC       activates target genes in the presence of AAI and also activates traR
CC       and traI themselves.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; AF010180; AAC17192.1; -; Genomic_DNA.
DR   EMBL; AE007871; AAK91098.1; -; Genomic_DNA.
DR   PIR; AD3244; AD3244.
DR   PIR; S25491; S25491.
DR   RefSeq; NP_396657.1; NC_003065.3.
DR   RefSeq; WP_010974900.1; NZ_AF010180.1.
DR   AlphaFoldDB; P54294; -.
DR   SMR; P54294; -.
DR   EnsemblBacteria; AAK91098; AAK91098; Atu6134.
DR   KEGG; atu:Atu6134; -.
DR   PATRIC; fig|176299.10.peg.5341; -.
DR   HOGENOM; CLU_072786_5_1_5; -.
DR   OMA; YNTVRIA; -.
DR   PhylomeDB; P54294; -.
DR   BioCyc; AGRO:ATU6134-MON; -.
DR   Proteomes; UP000000813; Plasmid Ti.
DR   CollecTF; EXPREG_00000b20; -.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:CollecTF.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IPI:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Conjugation; DNA-binding; Plasmid; Quorum sensing;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="Transcriptional activator protein TraR"
FT                   /id="PRO_0000184191"
FT   DOMAIN          167..232
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        191..210
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   234 AA;  26503 MW;  D9D23A80B9A29BD1 CRC64;
     MQHWLDKLTD LAAIQGDECI LKDGLADLAE HFGFTGYAYL HIQHKHTIAV TNYHRDWRSA
     YFENNFDKLD PVVKRAKSRK HVFAWSGEQE RSRLSKEERA FYAHAADFGI RSGITIPIKT
     ANGSMSMFTL ASERPAIDLD REIDAAAAAG AVGQLHARIS FLQTTPTVED AAWLDPKEAT
     YLRWIAVGMT MEEVADVEGV KYNSVRVKLR EAMKRFDVRS KAHLTALAIR RKLI