TRAR_SINFN
ID TRAR_SINFN Reviewed; 236 AA.
AC P55407;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Probable transcriptional activator protein TraR;
GN Name=traR; OrderedLocusNames=NGR_a04090; ORFNames=y4dH;
OS Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG Plasmid sym pNGR234a.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=394;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101917 / NGR234;
RX PubMed=9163424; DOI=10.1038/387394a0;
RA Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA Perret X.;
RT "Molecular basis of symbiosis between Rhizobium and legumes.";
RL Nature 387:394-401(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101917 / NGR234;
RX PubMed=19376903; DOI=10.1128/aem.00515-09;
RA Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT systems.";
RL Appl. Environ. Microbiol. 75:4035-4045(2009).
CC -!- FUNCTION: Positive regulation of conjugal transfer. TraR activates
CC target genes in the presence of AAI and also activates traR and traI
CC themselves (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P55407; P55408: traM; NbExp=3; IntAct=EBI-9014218, EBI-9014222;
CC -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC regulatory protein family. {ECO:0000305}.
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DR EMBL; U00090; AAB91637.1; -; Genomic_DNA.
DR RefSeq; NP_443817.1; NC_000914.2.
DR RefSeq; WP_010875419.1; NC_000914.2.
DR PDB; 2Q0O; X-ray; 2.00 A; A/B=1-236.
DR PDBsum; 2Q0O; -.
DR AlphaFoldDB; P55407; -.
DR SMR; P55407; -.
DR DIP; DIP-46219N; -.
DR IntAct; P55407; 1.
DR STRING; 394.NGR_a04090; -.
DR DrugBank; DB08081; 3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE.
DR EnsemblBacteria; AAB91637; AAB91637; NGR_a04090.
DR KEGG; rhi:NGR_a04090; -.
DR PATRIC; fig|394.7.peg.430; -.
DR eggNOG; COG2771; Bacteria.
DR HOGENOM; CLU_072786_5_1_5; -.
DR OMA; YNTVRIA; -.
DR OrthoDB; 1687028at2; -.
DR EvolutionaryTrace; P55407; -.
DR Proteomes; UP000001054; Plasmid sym pNGR234a.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.80; -; 1.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF03472; Autoind_bind; 1.
DR Pfam; PF00196; GerE; 1.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF75516; SSF75516; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Conjugation; DNA-binding; Plasmid; Quorum sensing;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..236
FT /note="Probable transcriptional activator protein TraR"
FT /id="PRO_0000184194"
FT DOMAIN 169..234
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 193..212
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT HELIX 3..16
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 20..34
FT /evidence="ECO:0007829|PDB:2Q0O"
FT STRAND 38..45
FT /evidence="ECO:0007829|PDB:2Q0O"
FT STRAND 48..53
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 57..65
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 68..70
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 73..80
FT /evidence="ECO:0007829|PDB:2Q0O"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 99..109
FT /evidence="ECO:0007829|PDB:2Q0O"
FT STRAND 114..121
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 123..125
FT /evidence="ECO:0007829|PDB:2Q0O"
FT STRAND 127..137
FT /evidence="ECO:0007829|PDB:2Q0O"
FT TURN 142..144
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 147..166
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 172..174
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 178..188
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 193..200
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 204..218
FT /evidence="ECO:0007829|PDB:2Q0O"
FT HELIX 223..232
FT /evidence="ECO:0007829|PDB:2Q0O"
SQ SEQUENCE 236 AA; 26287 MW; CE2A8DDAB99F7652 CRC64;
MSVNGNLRSL IDMLEAAQDG HMIKIALRSF AHSCGYDRFA YLQKDGTQVR TFHSYPGPWE
SIYLGSDYFN IDPVLAEAKR RRDVFFWTAD AWPARGSSPL RRFRDEAISH GIRCGVTIPV
EGSYGSAMML TFASPERKVD ISGVLDPKKA VQLLMMVHYQ LKIIAAKTVL NPKQMLSPRE
MLCLVWASKG KTASVTANLT GINARTVQHY LDKARAKLDA ESVPQLVAIA KDRGLV
