ID   TRAT1_BOVIN             Reviewed;         193 AA.
AC   Q3SYX1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=T-cell receptor-associated transmembrane adapter 1;
DE   AltName: Full=T-cell receptor-interacting molecule;
DE            Short=TRIM;
GN   Name=TRAT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at
CC       the surface of T-cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with CD3Z. When
CC       phosphorylated, interacts with PIK3R1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosines upon TCR activation. {ECO:0000250}.
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DR   EMBL; BC103345; AAI03346.1; -; mRNA.
DR   RefSeq; NP_001157415.1; NM_001163943.1.
DR   AlphaFoldDB; Q3SYX1; -.
DR   STRING; 9913.ENSBTAP00000034426; -.
DR   PaxDb; Q3SYX1; -.
DR   PRIDE; Q3SYX1; -.
DR   GeneID; 614942; -.
DR   KEGG; bta:614942; -.
DR   CTD; 50852; -.
DR   eggNOG; ENOG502S7P1; Eukaryota.
DR   InParanoid; Q3SYX1; -.
DR   OrthoDB; 1572760at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042101; C:T cell receptor complex; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0001920; P:negative regulation of receptor recycling; IBA:GO_Central.
DR   GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR020399; T-cell_rcpt-assoc_TM_adapter-1.
DR   PANTHER; PTHR15951; PTHR15951; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Cell membrane; Disulfide bond; Immunity; Membrane;
KW   Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..193
FT                   /note="T-cell receptor-associated transmembrane adapter 1"
FT                   /id="PRO_0000083343"
FT   TOPO_DOM        1..10
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..193
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          80..83
FT                   /note="Interaction with PIK3R1"
FT                   /evidence="ECO:0000250"
FT   REGION          116..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         46
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UU67"
FT   MOD_RES         80
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PIZ9"
FT   DISULFID        7
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   193 AA;  22149 MW;  4DD5C1E353237E96 CRC64;
     MSGNAECHFS IWAILAFLGL ALTISLIFNI FHCVEKQRQE KICTYSDDYF PREDEYDLED
     SPIYGNVDNV ALEPVDENCY EQMKARPDRS VNKLQDAPPS QETAVRVCYA SLDHNNEGKR
     RKPRKQKSHL SDKDEEGQMH AKDISLSKTT LVDSYPPESE AIEENIHDDP IRLFGLIRAQ
     KESLHSLDYD LAQ