ID   TRA_HAEIN               Reviewed;         687 AA.
AC   O05069;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Mu-like prophage FluMu transposase A;
GN   OrderedLocusNames=HI_1478;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: This transposase is essential for integration, replication-
CC       transposition, and excision of Mu-like viral DNA. {ECO:0000250}.
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DR   EMBL; L42023; AAC23125.1; -; Genomic_DNA.
DR   PIR; B64126; B64126.
DR   RefSeq; NP_439629.1; NC_000907.1.
DR   RefSeq; WP_010869221.1; NC_000907.1.
DR   STRING; 71421.HI_1478; -.
DR   EnsemblBacteria; AAC23125; AAC23125; HI_1478.
DR   KEGG; hin:HI_1478; -.
DR   PATRIC; fig|71421.8.peg.1546; -.
DR   eggNOG; COG2801; Bacteria.
DR   HOGENOM; CLU_027265_1_0_6; -.
DR   OMA; AMEWING; -.
DR   PhylomeDB; O05069; -.
DR   BioCyc; HINF71421:G1GJ1-1503-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004803; F:transposase activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.30.30.130; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR003314; Mu-type_HTH.
DR   InterPro; IPR015126; Mu_I-gamma.
DR   InterPro; IPR004189; Phage_Mu_transposase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR015378; Transposase-like_Mu_C.
DR   InterPro; IPR009004; Transposase_Mu_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF02914; DDE_2; 1.
DR   Pfam; PF02316; HTH_Tnp_Mu_1; 1.
DR   Pfam; PF09039; HTH_Tnp_Mu_2; 1.
DR   Pfam; PF09299; Mu-transpos_C; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   SUPFAM; SSF50610; SSF50610; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS51702; HTH_MU; 1.
PE   3: Inferred from homology;
KW   DNA excision; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome; Transposable element; Transposition.
FT   CHAIN           1..687
FT                   /note="Mu-like prophage FluMu transposase A"
FT                   /id="PRO_0000077585"
FT   DOMAIN          8..74
FT                   /note="HTH Mu-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01039"
FT   DNA_BIND        398..417
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01039"
SQ   SEQUENCE   687 AA;  78720 MW;  AC3A34DFDB68CB24 CRC64;
     MDNQSLKTHY SVYELANLKL KTLPSAPKNI WEQAKRENWK SQKRQGRGGG LEYELASLPI
     EVQNELLLKT TPEQTAVALQ KIEETRPLAS NEVWQLWDEA SAKAQEQAKI KLGTMFAVAN
     LVESGVNVLD AFRLVCGKEN AERLKNNEKL LSVGSLKNWW YRVKDAPRQD WLPLMLNNSG
     KSSKNVAEID EAAWQFFKNF YYSREKPSLA HSYEVLKQAA QYNGWRIPSR SSLKRKMERD
     VPKTEEVFRR EGQYALSRLY PSQVRTVAML QAMEWINGDG YQHNVWVRFP DGEIKRPKTW
     LWQDVRTRKV LAARTDKSEN TDTIRLSLLD VISRYGLPKH LTIDNTRAAA NKKMTGGVKN
     RYRYQVNENE VQGIIPALGI ELHWTSIQFG KGRGQAKPIE RAFSHGGLGD YVDKHLLLRG
     AYAGANAYEK PDYDGKNGAE QPVDYATFLM ALEQGIQQWN NVGNRLTEIC AGKSSYAEAF
     ERDWAVAEKR PISQSQMRLL LTLHEEVRLN QDGTFYLNAG KIGTNKNRYE SLALIGTSHK
     RVVVRYDPAN LHDKVWVYAX TGEYLAEAEI TEKAGFGDQM AGREHNKAMR NWVKHTEKAA
     KERAKAEEME LSNYAPAVEF EERFLEMLPE PVKAPQTQAE EVEYEEVLDF NTVRKVPKAV
     EVEAEEISEF NRDWEKGLEL LKKSKGR