ID   TRDD1_HUMAN             Reviewed;           2 AA.
AC   P0DPR3;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2018, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=T cell receptor delta diversity 1 {ECO:0000303|Ref.2};
GN   Name=TRDD1 {ECO:0000303|Ref.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE TRDD1*01).
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2]
RP   NOMENCLATURE.
RA   Lefranc M.P., Lefranc G.;
RT   "The T Cell Receptor FactsBook.";
RL   (In) Lefranc M.P., Lefranc G. (eds.);
RL   The T Cell Receptor FactsBook., pp.1-397, Academic Press, London. (2001).
RN   [3]
RP   REVIEW ON FUNCTION AND ANTIGEN RECOGNITION.
RX   PubMed=23348415; DOI=10.1038/nri3384;
RA   Vantourout P., Hayday A.;
RT   "Six-of-the-best: unique contributions of gammadelta T cells to
RT   immunology.";
RL   Nat. Rev. Immunol. 13:88-100(2013).
RN   [4]
RP   REVIEW ON DELTA T CELL RECEPTOR DIVERSITY.
RX   PubMed=24387714; DOI=10.1146/annurev-immunol-032713-120216;
RA   Chien Y.H., Meyer C., Bonneville M.;
RT   "gammadelta T cells: first line of defense and beyond.";
RL   Annu. Rev. Immunol. 32:121-155(2014).
RN   [5]
RP   NOMENCLATURE.
RX   PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA   Lefranc M.P.;
RT   "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT   of Immunoinformatics.";
RL   Front. Immunol. 5:22-22(2014).
RN   [6]
RP   REVIEW ON T CELL RECEPTOR SIGNALING, AND SUBUNIT.
RX   PubMed=25674089; DOI=10.3389/fimmu.2015.00015;
RA   Ribeiro S.T., Ribot J.C., Silva-Santos B.;
RT   "Five Layers of Receptor Signaling in gammadelta T-Cell Differentiation and
RT   Activation.";
RL   Front. Immunol. 6:15-15(2015).
RN   [7]
RP   REVIEW ON FUNCTION.
RX   PubMed=28920588; DOI=10.1038/nri.2017.101;
RA   Nielsen M.M., Witherden D.A., Havran W.L.;
RT   "gammadelta T cells in homeostasis and host defence of epithelial barrier
RT   tissues.";
RL   Nat. Rev. Immunol. 17:733-745(2017).
CC   -!- FUNCTION: D region of the variable domain of T cell receptor (TR) delta
CC       chain that participates in the antigen recognition (PubMed:24600447).
CC       Gamma-delta TRs recognize a variety of self and foreign non-peptide
CC       antigens frequently expressed at the epithelial boundaries between the
CC       host and external environment, including endogenous lipids presented by
CC       MH-like protein CD1D and phosphoantigens presented by butyrophilin-like
CC       molecule BTN3A1. Upon antigen recognition induces rapid, innate-like
CC       immune responses involved in pathogen clearance and tissue repair
CC       (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex
CC       to antigen triggers phosphorylation of immunoreceptor tyrosine-based
CC       activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases,
CC       allowing the recruitment, phosphorylation, and activation of ZAP70 that
CC       facilitates phosphorylation of the scaffolding proteins LCP2 and LAT.
CC       This lead to the formation of a supramolecular signalosome that
CC       recruits the phospholipase PLCG1, resulting in calcium mobilization and
CC       ERK activation, ultimately leading to T cell expansion and
CC       differentiation into effector cells (PubMed:25674089). Gamma-delta TRs
CC       are produced through somatic rearrangement of a limited repertoire of
CC       variable (V), diversity (D), and joining (J) genes. The potential
CC       diversity of gamma-delta TRs is conferred by the unique ability to
CC       rearrange (D) genes in tandem and to utilize all three reading frames.
CC       The combinatorial diversity is considerably increased by the sequence
CC       exonuclease trimming and random nucleotide (N) region additions which
CC       occur during the V-(D)-J rearrangements (PubMed:24387714).
CC       {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714,
CC       ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089,
CC       ECO:0000303|PubMed:28920588}.
CC   -!- SUBUNIT: Gamma-delta TR is a heterodimer composed of a gamma and delta
CC       chain; disulfide-linked. The gamma-delta TR is associated with the
CC       transmembrane signaling CD3 coreceptor proteins following the
CC       stoichiometry: a single gamma-delta TR heterodimer associates with one
CC       CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247
CC       homodimer forming a stable octomeric structure. Upon activation, gamma-
CC       delta TR complex associates with FCER1G to initiate intracellular
CC       signaling. {ECO:0000303|PubMed:25674089}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
CC   -!- POLYMORPHISM: There are several alleles. The sequence shown is that of
CC       IMGT allele TRDD1*01. {ECO:0000305}.
CC   -!- CAUTION: There are several genes encoding the D region in the T cell
CC       receptor delta locus. The peptide described in this entry is a
CC       representative for all the peptides encoded by these genes.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC244502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IMGT_GENE-DB; TRDD1; -.
DR   Ensembl; ENST00000415118.1; ENSP00000451042.1; ENSG00000223997.1.
DR   GeneCards; TRDD1; -.
DR   HGNC; HGNC:12254; TRDD1.
DR   HPA; ENSG00000223997; Not detected.
DR   neXtProt; NX_P0DPR3; -.
DR   VEuPathDB; HostDB:ENSG00000223997; -.
DR   Pharos; P0DPR3; Tdark.
DR   PRO; PR:P0DPR3; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Cell membrane; Immunity; Membrane; Receptor;
KW   Reference proteome; T cell receptor.
FT   CHAIN           <1..>2
FT                   /note="T cell receptor delta diversity 1"
FT                   /id="PRO_0000445809"
FT   NON_TER         1
FT   NON_TER         2
SQ   SEQUENCE   2 AA;  260 MW;  605B700000000000 CRC64;
     EI