TRE12_DROSE
ID TRE12_DROSE Reviewed; 488 AA.
AC B4HNS1;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Facilitated trehalose transporter Tret1-2 homolog {ECO:0000250|UniProtKB:Q8MKK4};
GN Name=Tret1-2 {ECO:0000250|UniProtKB:Q8MKK4}; ORFNames=GM21299;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1] {ECO:0000312|EMBL:EDW47436.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW47436.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Fails to transport trehalose. {ECO:0000250|UniProtKB:Q8MKK4}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8MKK4,
CC ECO:0000255}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q8MKK4, ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
CC {ECO:0000250|UniProtKB:A1Z8N1, ECO:0000255}.
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DR EMBL; CH480816; EDW47436.1; -; Genomic_DNA.
DR RefSeq; XP_002033423.1; XM_002033387.1.
DR AlphaFoldDB; B4HNS1; -.
DR SMR; B4HNS1; -.
DR STRING; 7238.B4HNS1; -.
DR EnsemblMetazoa; FBtr0204284; FBpp0202776; FBgn0176180.
DR GeneID; 6608699; -.
DR KEGG; dse:6608699; -.
DR HOGENOM; CLU_001265_30_5_1; -.
DR OMA; DIKDMCE; -.
DR PhylomeDB; B4HNS1; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..488
FT /note="Facilitated trehalose transporter Tret1-2 homolog"
FT /id="PRO_0000395535"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..72
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..372
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..402
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..433
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 455..488
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 488 AA; 53115 MW; BA718563C5F25600 CRC64;
MKILMRADTH VSYSVPAEGT KANFTFSQVL AALSVSLCSL VVGFVSAYTS PALVSMTDRT
ITSFEVTKDA GSWVGGIMPL AALAGGITGG PLIEYLGRRN TILATAVPFI VSSLLIACAV
NVIMILCGRF LTGFCVGIAS LSLPVYLGET LQPEVRGTLG LLPTALGNIG ILVCYVAGSF
MNWSILAFLG AALPVPFLIL MIIIPETPRW FVNRGQEERA RKALKWLRGK EADVEPELKD
LMQSQAEADS QATRNTCLEL FKRINLKPLS ISLGLMFFQQ FSGINAVIFY TVQIFKDAGS
TIDSNLCTII VGIVNFFATF MGIILIDRLG RKILLYVSDI AMILTLSILG GFFYCKAHGP
DVSHLGWLPL SCFVIYILGF SLGFGPIPWL MMGEILPAKI RGPAASVVTA FNWFCTFVVT
KTFQDLTVAM GPHGAFWLFG VVCIVGLFFV IIYVPETRGK SLEEIERKMM GRVPISAVVN
IKPFSFNM
