TRE1_YEAST
ID TRE1_YEAST Reviewed; 783 AA.
AC Q08919; D6W3J2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Uncharacterized protein TRE1;
DE AltName: Full=Transferrin receptor-like protein 1;
GN Name=TRE1; OrderedLocusNames=YPL176C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=12374868; DOI=10.1073/pnas.172517799;
RA Bagnat M., Simons K.;
RT "Cell surface polarization during yeast mating.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14183-14188(2002).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- INTERACTION:
CC Q08919; P39940: RSP5; NbExp=3; IntAct=EBI-31915, EBI-16219;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z73532; CAA97883.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11258.1; -; Genomic_DNA.
DR PIR; S65188; S65188.
DR RefSeq; NP_015149.1; NM_001183990.1.
DR AlphaFoldDB; Q08919; -.
DR SMR; Q08919; -.
DR BioGRID; 36007; 45.
DR IntAct; Q08919; 5.
DR MINT; Q08919; -.
DR STRING; 4932.YPL176C; -.
DR TCDB; 9.B.229.1.6; the transferrin receptor, cd71, (tfr) family.
DR iPTMnet; Q08919; -.
DR MaxQB; Q08919; -.
DR PaxDb; Q08919; -.
DR PRIDE; Q08919; -.
DR EnsemblFungi; YPL176C_mRNA; YPL176C; YPL176C.
DR GeneID; 855927; -.
DR KEGG; sce:YPL176C; -.
DR SGD; S000006097; TRE1.
DR VEuPathDB; FungiDB:YPL176C; -.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_1_1_1; -.
DR InParanoid; Q08919; -.
DR OMA; RIIDPIY; -.
DR BioCyc; YEAST:G3O-34071-MON; -.
DR Reactome; R-SCE-8963693; Aspartate and asparagine metabolism.
DR Reactome; R-SCE-8980692; RHOA GTPase cycle.
DR Reactome; R-SCE-9013026; RHOB GTPase cycle.
DR Reactome; R-SCE-9013106; RHOC GTPase cycle.
DR Reactome; R-SCE-9696273; RND1 GTPase cycle.
DR PRO; PR:Q08919; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q08919; protein.
DR GO; GO:0000324; C:fungal-type vacuole; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004180; F:carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IGI:SGD.
DR Gene3D; 1.20.930.40; -; 1.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404; PTHR10404; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF47672; SSF47672; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..783
FT /note="Uncharacterized protein TRE1"
FT /id="PRO_0000238622"
FT TOPO_DOM 1..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..127
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..783
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 241..333
FT /note="PA"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 529
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 783 AA; 88756 MW; 85D78D5D2FE114A7 CRC64;
MVNTRGYTTL PNVEEPANNS QDELNSQDFE QAIGMPSEPP VYVEEMGMEE PQAPEAFSEK
VQRFRMCFEN NVVIPVKKNV VDPLAQMISL ASEKFDLFLS KIGNVMVMRR IFYIMMMSII
AALIIASDRL PNGKARGSNG SFSDHDLLLQ YARKSIDLSK IERDLEYISS MPHMSGTSGD
AAIRHYIKES FDKNGIRLAG EEEFMAYSNY PGNVSLRVYS KDDTEGFDIP LNEENFNPMS
HNGQLNNIPV IYANKASLDD MASMQDQGLL NGDFILLVHY GDYVFQQMLT AQEYGAKAII
FISEPYQDNK DVIQMKSVAL PQYGTGDALT PEWEGSIRDP IDATEAKCLP KIPSIPISAN
QGDKILAILS DTGVKFSNNL FSGSLNDCRL DLLVQTAIRE RHPVHDIVGK IEGSEQAGRA
IVIAAPRNSA SYGTMYPSFG TVVLLSLIQL YQEMVYKFDW KPLRNIYFIS FGGSEFNEAG
ATELMEKRTE ALKSEIYTII DVGQIGIWDD SNNLEIQCHP LLVDLFQKNM TSRKFNVKVD
NVHQFGDWTP YLAQGIPVAI ISSPGVMNRE HPIYTVEDKF DFIKDKLRDK KKGEVLSEIM
LYLVEKSLEL IDDPFIPFSI SNYVDFLSTT LKDLQKECPD TVNFDEVFLG TTLWENTKLQ
FEKWKSEWTE LMYGAGTYIE PTIIAINRWS WNYLLSLIGV TQCLEEGLMD RTFYKNVIFG
PKLWVDKGDP LRSWTFPEIR DTIAIKDWSS VQVQANTLGT ILQNTARYFL ENKNLHGINT
NEF
