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TRET1_DROYA
ID   TRET1_DROYA             Reviewed;         856 AA.
AC   B4P624;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Facilitated trehalose transporter Tret1 {ECO:0000250|UniProtKB:A1Z8N1};
GN   Name=Tret1 {ECO:0000250|UniProtKB:A1Z8N1}; ORFNames=GE12373;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:EDW90899.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW90899.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Low-capacity facilitative transporter for trehalose. Does not
CC       transport maltose, sucrose or lactose. Mediates the bidirectional
CC       transfer of trehalose. Responsible for the transport of trehalose
CC       synthesized in the fat body and the incorporation of trehalose into
CC       other tissues that require a carbon source, thereby regulating
CC       trehalose levels in the hemolymph (By similarity).
CC       {ECO:0000250|UniProtKB:A1Z8N1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A1Z8N1};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:A1Z8N1}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
CC       {ECO:0000250|UniProtKB:A1Z8N1, ECO:0000255}.
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DR   EMBL; CM000158; EDW90899.1; -; Genomic_DNA.
DR   RefSeq; XP_002091187.1; XM_002091151.2.
DR   AlphaFoldDB; B4P624; -.
DR   SMR; B4P624; -.
DR   STRING; 7245.FBpp0257383; -.
DR   EnsemblMetazoa; FBtr0258891; FBpp0257383; FBgn0230119.
DR   GeneID; 6530250; -.
DR   KEGG; dya:Dyak_GE12373; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   HOGENOM; CLU_016710_0_0_1; -.
DR   OMA; IFIWTQS; -.
DR   OrthoDB; 430696at2759; -.
DR   PhylomeDB; B4P624; -.
DR   Proteomes; UP000002282; Chromosome 2R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015574; F:trehalose transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015771; P:trehalose transport; ISS:UniProtKB.
DR   CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..856
FT                   /note="Facilitated trehalose transporter Tret1"
FT                   /id="PRO_0000395550"
FT   TOPO_DOM        1..389
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        411..439
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        440..460
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        461..472
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        494..496
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        497..517
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        518..527
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        528..548
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        549..551
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..572
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        573..635
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        636..656
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        657..672
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        673..693
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        694..699
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        700..720
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        721..739
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        740..760
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        761..766
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        767..787
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        788..800
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        801..821
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        822..856
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         247
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   MOD_RES         248
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   MOD_RES         249
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   MOD_RES         319
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   MOD_RES         321
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   MOD_RES         844
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   MOD_RES         845
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A1Z8N1"
FT   CARBOHYD        427
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        549
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   856 AA;  94776 MW;  58062CEBBB53DB99 CRC64;
     MSGRDNRGAG GGGGGHQPLS NAMGKLKEKL TRVGDELGYH RVESNLSTSN TATSLDTILP
     EDPFLFPQVS PQRHPQTVRT QRLLEDEPPL SFRPLLEDDD INEPPTQQQK RTPLRASGSL
     ELTPLPPPPT SLEIREHRDR QQRGAQGDEL QRSKQSLKGS RVSFERRDTG NSNTNSNKAA
     ESSDEDSFEE KRTGFQQQKA TSVDHKGILK DLKHILANDN RRQFQAKKHV SLDVKGTRFL
     QDLLKESSSE EEFHKTRREF QGRKHQSLDP RVTFKLDKVL QGSSTDSDEE GEDAEHKRLI
     HRPKDITKPV IIDLKDLESE SDEDFLTSRQ HFQQQRSIST DSRKSRRLYE MDEMGNKRGE
     NIRHAVPFVR QITEDGKPKL EVYRPTTNPI FIWTQVIAAL SVSLGSLVVG FVSAYTSPAL
     VSMSDPNITS FTVTKDAGSW VGGIMPLAGL VGGVAGGPLI EYMGRRNTIL ATAVPFIVSS
     LLIACAVNVA MVLCGRFLAG FCVGIASLSL PVYLGETVQP EVRGTLGLLP TAFGNIGILV
     CFVAGSFMNW SMLAFLGAAL PVPFLILMFL IPETPRWYVS RGREERARKA LTWLRGKEAD
     VEPELKGLMR SQADADRQAT QNTMLELLKR NNLKPLSISL GLMFFQQFSG INAVIFYTVQ
     IFKDAGSTID GNVCTIIVGV VNFVATFIGI LLIDRAGRKI LLYASDIAMV LTLFVLGGFF
     YCKAHGPDVS HLGWLPLTCF VVYILGFSVG FGPIPWLMMG EILPAKIRGA AASVATSFNW
     TCTFVVTKTF QDLVGSLGAH GAFWLFGAIC FVGLFFVILY VPETQGKTLE DIERKMMGRV
     RRMSSVANIK PLSFNM
 
 
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