TRF1A_ARATH
ID TRF1A_ARATH Reviewed; 1055 AA.
AC Q8RY18; B9DG57; Q0WV70; Q9FIY4;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=TNF receptor-associated factor homolog 1a {ECO:0000305};
DE AltName: Full=MATH domain-containing protein At5g43560 {ECO:0000305};
DE AltName: Full=Protein MUTANT SNC1-ENHANCING 14 {ECO:0000303|PubMed:26867179};
GN Name=TRAF1A {ECO:0000303|PubMed:28351989};
GN Synonyms=MUSE14 {ECO:0000303|PubMed:26867179}; OrderedLocusNames=At5g43560;
GN ORFNames=K9D7.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-460 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP INTERACTION WITH AHK3.
RX PubMed=18642946; DOI=10.1021/pr0703831;
RA Dortay H., Gruhn N., Pfeifer A., Schwerdtner M., Schmuelling T., Heyl A.;
RT "Toward an interaction map of the two-component signaling pathway of
RT Arabidopsis thaliana.";
RL J. Proteome Res. 7:3649-3660(2008).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=26867179; DOI=10.1016/j.chom.2016.01.005;
RA Huang S., Chen X., Zhong X., Li M., Ao K., Huang J., Li X.;
RT "Plant TRAF proteins regulate NLR immune receptor turnover.";
RL Cell Host Microbe 19:204-215(2016).
RN [8]
RP FUNCTION, INTERACTION WITH ATG6; SINAT1; SINAT2; SINAT5 AND SINAT6,
RP SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=28351989; DOI=10.1105/tpc.17.00056;
RA Qi H., Xia F.N., Xie L.J., Yu L.J., Chen Q.F., Zhuang X.H., Wang Q., Li F.,
RA Jiang L., Xie Q., Xiao S.;
RT "TRAF family proteins regulate autophagy dynamics by modulating AUTOPHAGY
RT PROTEIN6 stability in Arabidopsis.";
RL Plant Cell 29:890-911(2017).
CC -!- FUNCTION: Functions redundantly with TRAF1B in the regulation of plant
CC immune response. Contributes to the turnover of the nucleotide-binding
CC domain and leucine-rich repeat-containing (NB-LRR) immune receptors
CC SNC1 and RPS2. May associate with an E3 ubiquitin-protein ligase
CC complex, which modulates ubiquitination and subsequent degradation of
CC NB-LRR immune sensors to maintain their homeostasis (PubMed:26867179).
CC Functions redundantly with TRAF1B in the regulation of autophagosome
CC formation. Required for SINAT1- and SINAT2-mediated ubiquitination and
CC destabilization of ATG6. Functions as molecular adapter that helps to
CC regulate autophagy by modulating ATG6 stability (PubMed:28351989).
CC {ECO:0000269|PubMed:26867179, ECO:0000269|PubMed:28351989}.
CC -!- SUBUNIT: Interacts with AHK3 (PubMed:18642946). Interacts with ATG6,
CC SINAT1, SINAT2, SINAT5 and SINAT6 (PubMed:28351989).
CC {ECO:0000269|PubMed:18642946, ECO:0000269|PubMed:28351989}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28351989}.
CC Note=Predominantly expressed in the cytoplasm. Associates with
CC starvation-induced autophagosomes in continuous darkness.
CC {ECO:0000269|PubMed:28351989}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8RY18-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8RY18-2; Sequence=VSP_039773;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but the double mutant plants traf1a and traf1b, or muse13
CC and muse14 are extremely dwarf when grown at room temperature.
CC {ECO:0000269|PubMed:26867179}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11619.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB016875; BAB11619.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED94981.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94982.1; -; Genomic_DNA.
DR EMBL; AY078956; AAL84956.1; -; mRNA.
DR EMBL; AK226901; BAE98978.1; -; mRNA.
DR EMBL; AK317030; BAH19724.1; -; mRNA.
DR RefSeq; NP_199169.1; NM_123722.5. [Q8RY18-1]
DR RefSeq; NP_851125.1; NM_180794.5. [Q8RY18-1]
DR AlphaFoldDB; Q8RY18; -.
DR SMR; Q8RY18; -.
DR BioGRID; 19626; 2.
DR IntAct; Q8RY18; 1.
DR STRING; 3702.AT5G43560.1; -.
DR iPTMnet; Q8RY18; -.
DR PaxDb; Q8RY18; -.
DR PRIDE; Q8RY18; -.
DR ProteomicsDB; 228297; -. [Q8RY18-1]
DR EnsemblPlants; AT5G43560.1; AT5G43560.1; AT5G43560. [Q8RY18-1]
DR EnsemblPlants; AT5G43560.2; AT5G43560.2; AT5G43560. [Q8RY18-1]
DR GeneID; 834376; -.
DR Gramene; AT5G43560.1; AT5G43560.1; AT5G43560. [Q8RY18-1]
DR Gramene; AT5G43560.2; AT5G43560.2; AT5G43560. [Q8RY18-1]
DR KEGG; ath:AT5G43560; -.
DR Araport; AT5G43560; -.
DR TAIR; locus:2158387; AT5G43560.
DR eggNOG; ENOG502QW6P; Eukaryota.
DR HOGENOM; CLU_005068_0_0_1; -.
DR InParanoid; Q8RY18; -.
DR OMA; NVEQICW; -.
DR OrthoDB; 145806at2759; -.
DR PhylomeDB; Q8RY18; -.
DR PRO; PR:Q8RY18; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8RY18; baseline and differential.
DR Genevisible; Q8RY18; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0043424; F:protein histidine kinase binding; IPI:UniProtKB.
DR GO; GO:1905037; P:autophagosome organization; IMP:TAIR.
DR GO; GO:0045087; P:innate immune response; IGI:TAIR.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 2.60.210.10; -; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR Pfam; PF00917; MATH; 1.
DR SMART; SM00061; MATH; 1.
DR PROSITE; PS50144; MATH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Reference proteome.
FT CHAIN 1..1055
FT /note="TNF receptor-associated factor homolog 1a"
FT /id="PRO_0000398602"
FT DOMAIN 68..191
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 441..496
FT /evidence="ECO:0000255"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..772
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..464
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_039773"
FT CONFLICT 349
FT /note="E -> G (in Ref. 5; BAH19724)"
FT /evidence="ECO:0000305"
FT CONFLICT 453
FT /note="A -> T (in Ref. 5; BAH19724)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1055 AA; 117449 MW; 4A7A757807E3FA45 CRC64;
MSESTNEDSG AGRSSLEENS NGQRSQSEEA IAEWRSSEQV ENGTPSTSPP YWDIDDDDDF
GSKPSQLFGK NTWTIEKFSD INKRELRGDV FEVGGYKWYI LIYPQGCDVC NHLSLFLCVA
HHEKLLPGWS HFAQFTIAVS NKDPKKSKHS DTLHRFWKKE HDWGWKKFIE LPKLKEGFID
DSGCLTIKAQ VQVIRERVDR PFRCLHYKYR EELVRVYLGN VEQICWRFVE EKRSKLGRLI
EDKAKWKSFC AFWMGLDQNS RRRMSREKMD VILKIVVKHF FVEKEVTSTL VMDSLYSGLK
ALEGQNKNKE SRPRLMDTEE STAPIVSVDK DSFALVDDVL LLLEKAALEP LPKKEEKSSQ
NRTKDGNAGE EFSREAVERD DRRLTELGRR TVEIFVLAHI FSNKIEVAYQ EAIAWKRQEE
LIREEEEAWL AESEQKGKRG ASEKEKKSKK KQAKQKKNKN KGKEMRKEDK VRTQTEEREI
EKEECVRAIA ESSAEKPDTL GDVSDVSDSV DSSAEILQLD SEDRESSPVH WEMDASEVHP
PSAGDTSRGR GNSFSIPNGV AERKGLSTMD DSSSTCSNDS IQSGVANGSY KGNVLNCQSQ
KWFSNGKIQP GKVSDSNSLA SEKEHQPSRL ASDPKNQSHS SDIRRVGEAD IVISHIQKPE
SPKERSPVSK DPNMIQMKEK SAAVLSPSRA APWNPPSPVQ AKPEKKGVSN VEAVPNRKVI
SVKSPSSHHA SPSREAQLQT VGPRADIQKI ASPKPVEQPA PPMSRPLSAP IIPPTQAAPV
ISAVQTSTAS LARSMSSTGR LGSPTHSQAY NPQSYKHAIV GSSGFTHPSS QSSGTSTLPP
YSHPSPISVS NQSGFPINVG SWDVSSGGLL WTGGSSSTRD TTTTISGNHK TNTYNAPVVT
TSIRPTNVQI GRTAQSLMTD EFPHLDIIND LLADEHGTMD NSVYRVPQQF NNQYSYHGGA
DLGISSRSRS YSDDGFHQSY GEYMPHSASS SPYGNGQTQS QWQMANMDFS LPAMRNQDDV
SASATATYSY FDLDSSNPNL SGINGYRDFR PSNGH