ID   TRF1_MAGO7              Reviewed;         742 AA.
AC   G4N2A1;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 2.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Pyriculol/pyriculariol biosynthesis cluster transcription factor 1 {ECO:0000303|PubMed:27902426};
GN   Name=TRF1 {ECO:0000303|PubMed:27902426}; ORFNames=MGG_04843;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   IDENTIFICATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=27902426; DOI=10.1099/mic.0.000396;
RA   Jacob S., Groetsch T., Foster A.J., Schueffler A., Rieger P.H.,
RA   Sandjo L.P., Liermann J.C., Opatz T., Thines E.;
RT   "Unravelling the biosynthesis of pyriculol in the rice blast fungus
RT   Magnaporthe oryzae.";
RL   Microbiology 163:541-553(2017).
CC   -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC       mediates the biosynthesis of pyriculol and pyriculariol, two
CC       heptaketides that induce lesion formation upon application on rice
CC       leaves but are dispensable for pathogenicity (PubMed:27902426). With
CC       TRF2, negatively regulates the expression of the gene cluster and the
CC       subsequent pyriculol and pyriculariol production (PubMed:27902426).
CC       {ECO:0000269|PubMed:27902426}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DISRUPTION PHENOTYPE: Leads to increased expression of the
CC       pyriculol/pyriculariol biosynthesis cluster highly reducing polyketide
CC       synthase PKS19. {ECO:0000269|PubMed:27902426}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EHA52513.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM001233; EHA52513.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_003712320.1; XM_003712272.1.
DR   AlphaFoldDB; G4N2A1; -.
DR   STRING; 242507.G4N2A1; -.
DR   EnsemblFungi; MGG_04843T0; MGG_04843T0; MGG_04843.
DR   GeneID; 2675309; -.
DR   KEGG; mgr:MGG_04843; -.
DR   eggNOG; ENOG502QYWX; Eukaryota.
DR   HOGENOM; CLU_004083_5_3_1; -.
DR   InParanoid; G4N2A1; -.
DR   OrthoDB; 1245474at2759; -.
DR   PHI-base; PHI:5601; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..742
FT                   /note="Pyriculol/pyriculariol biosynthesis cluster
FT                   transcription factor 1"
FT                   /id="PRO_0000446271"
FT   DNA_BIND        23..49
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          85..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  83190 MW;  9495F281B36AAAEA CRC64;
     MSSAAASATA GSVTGKTPRI LACVLCQHRK IKCDRSFPCA NCQRANVQCT PSTPAPARKR
     RRPNQDLQER LARCEELLKE YAPDGKPDIA RLTTKRSSLS QSPPKGEEPL PEWNRHGKLI
     HEDGSVRFVD SYMLSTIYDE LRAMRDIIDH DESTPEDESS DYMTPDTNAD LLFGGDTPQP
     AGNSMELQPS PGHIFRLWQV FLDRVNPLIK LVHVPSLQPY FVEATAGAPL PKNIEALLFS
     IYTLAAVSLS DAECTSILGY GREAALHRFS SGVRASLIRI GFLKTHDLTT LQALVHYLIS
     LQGRYNRHAA WVLNGVVIRI AQKMGIHRDG TMLGLPPFET EMRRRLWFQI LSMEFKTALM
     SGLGHSLLPR VWDTQEPKNV NDADLHPSAT EPVKDREGPT EMIFVLITNK VARFIVESPG
     IEPIFLYHDE KVKKIPGAPS EEKIKEFRGL IDGLSKSLLE LTDKYCDPAA GPLHQYTIEF
     QDIIMQRIRE SLEPGDATIE THIDHMFKMA VESFESTVVS YRNSCKVAYL WFLRLQFHND
     LFTFLAGQLS QRPSGPLVDR AWETVENILP YHPELLKVNA SKENLLLASL LVKGWNMREE
     YCSTQMGITL NTPPYIEHLR SVVPQDYVKS ENSSPSALSR IPKANRMVTR EAASDQLSVS
     GPMDPTFDEF IGNYLDGADW DVFSRINLEN PAFPGVPATG ITPQVNATAS DILPSTRIDH
     TDPNQTSHQF AMYGIDPQSA WQ