ID   TRF2_MAGO7              Reviewed;         625 AA.
AC   G4N2B2;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Pyriculol/pyriculariol biosynthesis cluster transcription factor 1 {ECO:0000303|PubMed:27902426};
GN   Name=TRF2 {ECO:0000303|PubMed:27902426}; ORFNames=MGG_04853;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   IDENTIFICATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=27902426; DOI=10.1099/mic.0.000396;
RA   Jacob S., Groetsch T., Foster A.J., Schueffler A., Rieger P.H.,
RA   Sandjo L.P., Liermann J.C., Opatz T., Thines E.;
RT   "Unravelling the biosynthesis of pyriculol in the rice blast fungus
RT   Magnaporthe oryzae.";
RL   Microbiology 163:541-553(2017).
CC   -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC       mediates the biosynthesis of pyriculol and pyriculariol, two
CC       heptaketides that induce lesion formation upon application on rice
CC       leaves but are dispensable for pathogenicity (PubMed:27902426). With
CC       TRF1, negatively regulates the expression of the gene cluster and the
CC       subsequent pyriculol and pyriculariol production (PubMed:27902426).
CC       {ECO:0000269|PubMed:27902426}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DISRUPTION PHENOTYPE: Leads to increased expression of the
CC       pyriculol/pyriculariol biosynthesis cluster highly reducing polyketide
CC       synthase PKS19. {ECO:0000269|PubMed:27902426}.
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DR   EMBL; CM001233; EHA52524.1; -; Genomic_DNA.
DR   RefSeq; XP_003712331.1; XM_003712283.1.
DR   AlphaFoldDB; G4N2B2; -.
DR   SMR; G4N2B2; -.
DR   STRING; 318829.MGG_04853T0; -.
DR   EnsemblFungi; MGG_04853T0; MGG_04853T0; MGG_04853.
DR   GeneID; 2675295; -.
DR   KEGG; mgr:MGG_04853; -.
DR   VEuPathDB; FungiDB:MGG_04853; -.
DR   eggNOG; KOG0849; Eukaryota.
DR   HOGENOM; CLU_023524_1_0_1; -.
DR   InParanoid; G4N2B2; -.
DR   OMA; IMVHHLG; -.
DR   OrthoDB; 1014909at2759; -.
DR   PHI-base; PHI:2128; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..625
FT                   /note="Pyriculol/pyriculariol biosynthesis cluster
FT                   transcription factor 1"
FT                   /id="PRO_0000446272"
FT   DNA_BIND        73..132
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..496
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  67910 MW;  6E1C36F341889255 CRC64;
     MATEINMPMG PGPLGEAGSL KIDTGSNMEV SIPSPVSAAP GELNETPSPS TPANPNSASR
     RPPRKSTLTQ QQKNQKRQRA TQDQLTTLEQ EFAKNPTPTA TVRDRIAEEI NMTERSVQIW
     FQNRRAKIKL MAKKSLETGE DIDSIPESMR TYLAMQAMES GKGFPGAFLG RGMMPYGHGN
     MLMAGEQGGP SKVVIHHLTC RSLSIGKWTR VGQNTMDLIV FYSPDKCTMT YYINNEQAGY
     KIEYHFSCIK SICVENADDP TKVGGIVIEL NRPPSFFMDQ SPTSNGFFQC GDFTEDQQAS
     QCLVHHLGGN PKVLSGQLAK LVSLESFMNR HNTMAYHPDP MAHGGMPVSA PVSPTNRPSS
     QPNFAQPHVG LFQESQWGIS PAHHVMRGPG HKRQRSRSVP IAVDFSMLQT PMPSFYIQHP
     GEAQPQPHSP NIYAPVPQQP HALSPAGPGL RIDTQAGFGL DMRQYPMSAT TAPSPSEYNS
     PSFFSQAPEN TPLPASNFNT PYSSTFLSPM MNATNLNVPQ SVSPISFSGG DPAIVDQSPP
     MSMLGRSASA DIYHGGDSSA ISDDGHSLND MYSKHAITLP MHPPHSPAFV EPSQAELDMN
     QLVQFDTVDP SSLSPESVHQ GIGGQ