ID   BUD31_BOVIN             Reviewed;         144 AA.
AC   Q2NKU3; A5PJG0;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Protein BUD31 homolog;
DE   AltName: Full=Protein G10 homolog;
GN   Name=BUD31;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle, and Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the pre-mRNA splicing process. May play a role as
CC       regulator of AR transcriptional activity; may increase AR
CC       transcriptional activity. {ECO:0000250|UniProtKB:P41223}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. May interact with AR.
CC       {ECO:0000250|UniProtKB:P41223}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41223}.
CC       Note=Detected in chromatin at the promoter of AR target genes.
CC       {ECO:0000250|UniProtKB:P41223}.
CC   -!- DOMAIN: Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can
CC       bind to AR and may modulate AR activity.
CC       {ECO:0000250|UniProtKB:P41223}.
CC   -!- SIMILARITY: Belongs to the BUD31 (G10) family. {ECO:0000305}.
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DR   EMBL; BC111638; AAI11639.1; -; mRNA.
DR   EMBL; BC142096; AAI42097.1; -; mRNA.
DR   RefSeq; NP_001039829.1; NM_001046364.2.
DR   RefSeq; XP_005225221.1; XM_005225164.1.
DR   RefSeq; XP_005225222.1; XM_005225165.3.
DR   RefSeq; XP_005225223.1; XM_005225166.3.
DR   RefSeq; XP_005225224.1; XM_005225167.3.
DR   RefSeq; XP_005225225.1; XM_005225168.3.
DR   RefSeq; XP_015315969.1; XM_015460483.1.
DR   AlphaFoldDB; Q2NKU3; -.
DR   SMR; Q2NKU3; -.
DR   STRING; 9913.ENSBTAP00000036979; -.
DR   PaxDb; Q2NKU3; -.
DR   PRIDE; Q2NKU3; -.
DR   Ensembl; ENSBTAT00000037140; ENSBTAP00000036979; ENSBTAG00000020439.
DR   Ensembl; ENSBTAT00000080736; ENSBTAP00000061709; ENSBTAG00000020439.
DR   GeneID; 533977; -.
DR   KEGG; bta:533977; -.
DR   CTD; 8896; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020439; -.
DR   VGNC; VGNC:26609; BUD31.
DR   eggNOG; KOG3404; Eukaryota.
DR   GeneTree; ENSGT00390000014300; -.
DR   HOGENOM; CLU_087132_1_1_1; -.
DR   InParanoid; Q2NKU3; -.
DR   OMA; VRCIQSR; -.
DR   OrthoDB; 1236198at2759; -.
DR   TreeFam; TF105609; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000020439; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:Ensembl.
DR   GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:2000825; P:positive regulation of androgen receptor activity; ISS:UniProtKB.
DR   InterPro; IPR018230; BUD31/G10-rel_CS.
DR   InterPro; IPR001748; G10.
DR   PANTHER; PTHR19411; PTHR19411; 1.
DR   Pfam; PF01125; G10; 1.
DR   PRINTS; PR00322; G10.
DR   PROSITE; PS00997; G10_1; 1.
DR   PROSITE; PS00998; G10_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..144
FT                   /note="Protein BUD31 homolog"
FT                   /id="PRO_0000249854"
FT   REGION          59..67
FT                   /note="Interaction with AR"
FT                   /evidence="ECO:0000250|UniProtKB:P41223"
FT   MOTIF           2..10
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         125
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P41223"
SQ   SEQUENCE   144 AA;  17000 MW;  520B8E74C97D0926 CRC64;
     MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF RIHHQKTRYI
     FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL CCLRCIQTRD TNFGTNCICR
     VPKSKLEVGR IIECTHCGCR GCSG