TRFE_ORYLA
ID TRFE_ORYLA Reviewed; 690 AA.
AC P79819;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Serotransferrin;
DE Flags: Precursor;
GN Name=tf;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8817928;
RA Mikawa N., Hirono I., Aoki T.;
RT "Structure of medaka transferrin gene and its 5'-flanking region.";
RL Mol. Mar. Biol. Biotechnol. 5:225-229(1996).
CC -!- FUNCTION: Transferrins are iron binding transport proteins which can
CC bind two Fe(3+) ions in association with the binding of an anion,
CC usually bicarbonate.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the transferrin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00741}.
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DR EMBL; D64033; BAA10901.1; -; Genomic_DNA.
DR AlphaFoldDB; P79819; -.
DR SMR; P79819; -.
DR STRING; 8090.ENSORLP00000020672; -.
DR MEROPS; S60.970; -.
DR eggNOG; ENOG502QT0C; Eukaryota.
DR InParanoid; P79819; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IBA:GO_Central.
DR InterPro; IPR016357; Transferrin.
DR InterPro; IPR001156; Transferrin-like_dom.
DR InterPro; IPR018195; Transferrin_Fe_BS.
DR Pfam; PF00405; Transferrin; 2.
DR PIRSF; PIRSF002549; Transferrin; 1.
DR PRINTS; PR00422; TRANSFERRIN.
DR SMART; SM00094; TR_FER; 2.
DR PROSITE; PS00205; TRANSFERRIN_LIKE_1; 2.
DR PROSITE; PS00206; TRANSFERRIN_LIKE_2; 2.
DR PROSITE; PS00207; TRANSFERRIN_LIKE_3; 1.
DR PROSITE; PS51408; TRANSFERRIN_LIKE_4; 2.
PE 3: Inferred from homology;
KW Disulfide bond; Ion transport; Iron; Iron transport; Metal-binding;
KW Reference proteome; Repeat; Secreted; Signal; Transport.
FT SIGNAL 1..17
FT /evidence="ECO:0000250"
FT CHAIN 18..690
FT /note="Serotransferrin"
FT /id="PRO_0000035722"
FT DOMAIN 24..329
FT /note="Transferrin-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DOMAIN 340..670
FT /note="Transferrin-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 73
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 103
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 128
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 132
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 134
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 135
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 200
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 256
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 394
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 429
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 454
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 458
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 460
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 461
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 524
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 592
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 27..49
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 126..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 171..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 234..248
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 343..379
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 353..370
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 404..682
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 419..643
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 452..530
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 476..671
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 486..499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 496..513
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 570..584
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
SQ SEQUENCE 690 AA; 74601 MW; 2F996CA1AEE79570 CRC64;
MKPLLLLTLL GCLAAALAVP AQKVKWCVKS DQEFRKCSDL AAASPAFSCV KKESTLDCII
AIKAGEADAI TVDGGDVYTA GLNNYDLHPI IAEDYGTSSE TCYYAVAVAK KGTTFGIRDL
RGKKSCHTGL GKSAGWNIPI GTLVSMDIIQ WAGVEDKPVE EEVSTFFQAS CVPGATRGSK
LCELCKGDCS RSQKEPYYDY NGAFNCLAEG AGDVAFVKHL TVPDQEKSKY ELLCRDNTRA
PIDDYKKCNL ARVPAHAIVT HKDPQLAELI WTSLNSVQNF NLFSSEAYAP SKNLMFKDST
QRLVKLPQNT DSFLYLGAQY MSIVRSLKKE QSVGTNSNAI KWCAVGHAET AKCDTWSINS
VTDDTAAIEC QNAPSVEECL KKIMRKEADA MAVDGGEVYT AGKCGLVPAM VEQYDAELCS
SSGGQASSYY AVAVVKKDSG VTWENLKGKK SCHTGIGRTA GWNIPMGRIY DQTKDCDFTK
FFPSGCAPEP KPALHCALCV KAAAKLSGDE AKCKARPEEQ YYGYAGAFRC LAEGAGDVAF
IKHTIVGENT DGNGPDWARS LKSDDYQLIC PGKGPVPISE YASCNLAVVP AHAVVTRPES
RSDVVRVLQV QQTFFGASGS DPSFKLFQSQ NGNNLLFKDS TKCLQEVPAG TSYDQFLGSG
YMEAMTSLRK CSDTASDLEK SCTFHSCQQT
