TRF_BLADI
ID TRF_BLADI Reviewed; 726 AA.
AC Q02942;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transferrin;
DE Flags: Precursor;
OS Blaberus discoidalis (Tropical cockroach).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC Blaberinae; Blaberus.
OX NCBI_TaxID=6981;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 17-31.
RC TISSUE=Fat body;
RX PubMed=7679500; DOI=10.1073/pnas.90.4.1320;
RA Jamroz R.C., Gasdaska J.R., Bradfield J.Y., Law J.H.;
RT "Transferrin in a cockroach: molecular cloning, characterization, and
RT suppression by juvenile hormone.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:1320-1324(1993).
CC -!- FUNCTION: Transferrins are iron binding transport proteins which bind
CC Fe(3+) ion in association with the binding of an anion, usually
CC bicarbonate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the transferrin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00741}.
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DR EMBL; L05340; AAA27820.1; -; mRNA.
DR PIR; A47275; A47275.
DR AlphaFoldDB; Q02942; -.
DR SMR; Q02942; -.
DR MEROPS; S60.973; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR InterPro; IPR016357; Transferrin.
DR InterPro; IPR001156; Transferrin-like_dom.
DR InterPro; IPR018195; Transferrin_Fe_BS.
DR Pfam; PF00405; Transferrin; 2.
DR PIRSF; PIRSF002549; Transferrin; 1.
DR PRINTS; PR00422; TRANSFERRIN.
DR SMART; SM00094; TR_FER; 2.
DR PROSITE; PS00205; TRANSFERRIN_LIKE_1; 2.
DR PROSITE; PS00206; TRANSFERRIN_LIKE_2; 2.
DR PROSITE; PS00207; TRANSFERRIN_LIKE_3; 2.
DR PROSITE; PS51408; TRANSFERRIN_LIKE_4; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport;
KW Iron; Iron transport; Metal-binding; Repeat; Secreted; Signal; Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000269|PubMed:7679500"
FT CHAIN 17..726
FT /note="Transferrin"
FT /id="PRO_0000035746"
FT DOMAIN 29..367
FT /note="Transferrin-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DOMAIN 374..719
FT /note="Transferrin-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 78
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 111
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 137
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 141
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 143
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 144
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 225
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 429
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 457
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 483
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 487
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 489
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 490
FT /ligand="hydrogencarbonate"
FT /ligand_id="ChEBI:CHEBI:17544"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 573
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT BINDING 642
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 358
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..63
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 41..54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 135..231
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 184..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 207..216
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 274..287
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 377..414
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 387..405
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
FT DISULFID 481..562
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00741"
SQ SEQUENCE 726 AA; 80093 MW; 7445B1DC80D68AD1 CRC64;
MLLCLTLLFS ASAVLAMPTP EGSPHHEIYK VCVPEGALES CHRMSQESDL HMTCVAARDR
IECLDKIKHR EADFAPVDPE DMYVAAKIPQ QDFIIFKEIR TKEEPDEEFR YEAVCVIHKD
LDITSIHGLQ GLKSCHTGVG RNVGYKIPIT KLRHMGVLGP LNNSDLTPRE NELHALSHLF
SEACLVGKWA PDPAQNQALK AKYPNLCALC EHPEICDYPD KYSGYDGALR CLAEHGGQVA
WTKVYYVKKH FGMAIGAGEA VPTGQNPDDY AYLCPDATKK PITGKPCIWA ARPWQGYMAN
HDLDNDIADL RAKISLADTI GETENADWLS KVLDLNNKTI PIDNQGPYSP ENYLNKANYT
DVIERDTGAP HRPVRFCVTS DAELEKCRVL KRAAYSRDIR PAFDCVREAG LHECLRTVRD
DGADVITLDG GEVFVAQRQY NLKPIVAEQY GEHGSLYYAV AVVRKDSTYQ SIEDLRGAKS
CHTGYGRNAG WNVPLYTLLS KELISKNSCP YSSALSSYFS GGSCVPGAQL PENNPANQNP
DSLCSICAGN LDAPNNDPAW KCSASNDESF FGYSGAFRCL ASGEGQVAFV KHTTVPENTD
GHNQAAWTAG LRSEDFELLC ADGGRASINE YSRCHLAEVP PHMVVTSNDK TDIQLNEIRH
AILAAGDLYS RRPDLFKLFG DFGGTKDLLF KNSATGLLSV ENGSPLMQRY SEILEVIRAC
ENQPTP
