TRHA_XENLA
ID TRHA_XENLA Reviewed; 227 AA.
AC P01152;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Pro-thyrotropin-releasing hormone-A;
DE Short=Pro-TRH-A;
DE AltName: Full=Prothyroliberin type A;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=trh-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RX PubMed=1694847; DOI=10.1016/s0021-9258(19)38458-3;
RA Kuchler K., Richter K., Trnovsky J., Egger R., Kreil G.;
RT "Two precursors of thyrotropin-releasing hormone from skin of Xenopus
RT laevis. Each contains seven copies of the end product.";
RL J. Biol. Chem. 265:11731-11733(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-123.
RC TISSUE=Skin;
RX PubMed=6425056; DOI=10.1002/j.1460-2075.1984.tb01857.x;
RA Richter K., Kawashima E., Egger R., Kreil G.;
RT "Biosynthesis of thyrotropin releasing hormone in the skin of Xenopus
RT laevis: partial sequence of the precursor deduced from cloned cDNA.";
RL EMBO J. 3:617-621(1984).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: This precursor contains seven copies of thyroliberin.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; M34699; AAA49973.1; -; mRNA.
DR EMBL; M34698; AAA49974.1; -; mRNA.
DR EMBL; X00770; CAA25345.1; ALT_TERM; mRNA.
DR PIR; A37061; RHXLT.
DR RefSeq; NP_001081334.1; NM_001087865.1.
DR AlphaFoldDB; P01152; -.
DR GeneID; 397780; -.
DR CTD; 397780; -.
DR Xenbase; XB-GENE-5805996; trh.L.
DR OrthoDB; 1160959at2759; -.
DR Proteomes; UP000186698; Genome assembly.
DR Bgee; 397780; Expressed in zone of skin and 6 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..15
FT CHAIN 16..227
FT /note="Pro-thyrotropin-releasing hormone-A"
FT /id="PRO_0000022493"
FT PEPTIDE 75..77
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022494"
FT PEPTIDE 89..91
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022495"
FT PEPTIDE 107..109
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022496"
FT PEPTIDE 121..123
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022497"
FT PEPTIDE 153..155
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022498"
FT PEPTIDE 168..170
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022499"
FT PEPTIDE 193..195
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022500"
FT REGION 107..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 75
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 77
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 89
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 91
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 107
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 109
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 121
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 123
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 153
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 155
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 168
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 170
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 193
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 195
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT VARIANT 46
FT /note="L -> S"
FT VARIANT 70
FT /note="M -> I"
FT VARIANT 218..220
FT /note="Missing"
SQ SEQUENCE 227 AA; 26336 MW; 7DEC001E3154CD47 CRC64;
MVSVWWLLLL GTTVSHMVHT QEQPLLEEDT APLDDLDVLE KAKGILIRSI LEGFQEGQQN
NRDLPDAMEM ISKRQHPGKR FQEEIEKRQH PGKRDLEDLN LELSKRQHPG RRFVDDVEKR
QHPGKREEGD WSRRYLTDDS RYLDLLSDVS RRQHPGKRVP APLFTKRQHP GKRVTEEEGD
TEFENSKEVG KRQHPGKRYD PCEGPNAYNC NSGNILPDSV EELSFGL
