ID   BUD31_RAT               Reviewed;         144 AA.
AC   O70454; Q6PDW3;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Protein BUD31 homolog;
DE   AltName: Full=Protein EDG-2;
DE   AltName: Full=Protein G10 homolog;
GN   Name=Bud31; Synonyms=Edg2, G10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Liver;
RA   D'Amico T., Greenwel P., Ogata I., Rojkind M.;
RT   "Expression of edg2 (G10 maternal RNA homologue) in hepatic stellate cells
RT   from cirrhotic liver.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the pre-mRNA splicing process. May play a role as
CC       regulator of AR transcriptional activity; may increase AR
CC       transcriptional activity. {ECO:0000250|UniProtKB:P41223}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. May interact with AR.
CC       {ECO:0000250|UniProtKB:P41223}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41223}.
CC       Note=Detected in chromatin at the promoter of AR target genes.
CC       {ECO:0000250|UniProtKB:P41223}.
CC   -!- DOMAIN: Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can
CC       bind to AR and may modulate AR activity.
CC       {ECO:0000250|UniProtKB:P41223}.
CC   -!- SIMILARITY: Belongs to the BUD31 (G10) family. {ECO:0000305}.
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DR   EMBL; AF058791; AAC14190.1; -; mRNA.
DR   EMBL; BC058456; AAH58456.1; -; mRNA.
DR   RefSeq; NP_446008.1; NM_053556.1.
DR   RefSeq; XP_006248949.1; XM_006248887.2.
DR   RefSeq; XP_006248951.1; XM_006248889.2.
DR   RefSeq; XP_008767225.1; XM_008769003.1.
DR   AlphaFoldDB; O70454; -.
DR   SMR; O70454; -.
DR   STRING; 10116.ENSRNOP00000001307; -.
DR   iPTMnet; O70454; -.
DR   PhosphoSitePlus; O70454; -.
DR   jPOST; O70454; -.
DR   PaxDb; O70454; -.
DR   PRIDE; O70454; -.
DR   Ensembl; ENSRNOT00000001307; ENSRNOP00000001307; ENSRNOG00000000989.
DR   GeneID; 89819; -.
DR   KEGG; rno:89819; -.
DR   CTD; 8896; -.
DR   RGD; 621103; Bud31.
DR   eggNOG; KOG3404; Eukaryota.
DR   GeneTree; ENSGT00390000014300; -.
DR   InParanoid; O70454; -.
DR   OMA; VRCIQSR; -.
DR   OrthoDB; 1236198at2759; -.
DR   PhylomeDB; O70454; -.
DR   TreeFam; TF105609; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:O70454; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000000989; Expressed in thymus and 20 other tissues.
DR   ExpressionAtlas; O70454; baseline and differential.
DR   Genevisible; O70454; RN.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISO:RGD.
DR   GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISO:RGD.
DR   GO; GO:2000825; P:positive regulation of androgen receptor activity; ISS:UniProtKB.
DR   InterPro; IPR018230; BUD31/G10-rel_CS.
DR   InterPro; IPR001748; G10.
DR   PANTHER; PTHR19411; PTHR19411; 1.
DR   Pfam; PF01125; G10; 1.
DR   PRINTS; PR00322; G10.
DR   PROSITE; PS00997; G10_1; 1.
DR   PROSITE; PS00998; G10_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..144
FT                   /note="Protein BUD31 homolog"
FT                   /id="PRO_0000193898"
FT   REGION          59..67
FT                   /note="Interaction with AR"
FT                   /evidence="ECO:0000250|UniProtKB:P41223"
FT   MOTIF           2..10
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         125
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P41223"
FT   CONFLICT        133
FT                   /note="E -> D (in Ref. 1; AAC14190)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142
FT                   /note="C -> W (in Ref. 1; AAC14190)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   144 AA;  17000 MW;  520B8E74C97D0926 CRC64;
     MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF RIHHQKTRYI
     FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL CCLRCIQTRD TNFGTNCICR
     VPKSKLEVGR IIECTHCGCR GCSG