ID   TRHBN_MYCTO             Reviewed;         136 AA.
AC   P9WN24; L0T6Z0; P0A592; Q10784;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Group 1 truncated hemoglobin GlbN;
DE            Short=Truncated hemoglobin;
DE            Short=trHbN;
DE   AltName: Full=Hemoglobin-like protein HbN;
GN   Name=glbN; OrderedLocusNames=MT1594;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Binds oxygen cooperatively with very high affinity.
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC       Note=Binds 1 heme group per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the truncated hemoglobin family. Group I
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45860.1; -; Genomic_DNA.
DR   PIR; C70761; C70761.
DR   RefSeq; WP_003407730.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WN24; -.
DR   BMRB; P9WN24; -.
DR   SMR; P9WN24; -.
DR   EnsemblBacteria; AAK45860; AAK45860; MT1594.
DR   GeneID; 45425525; -.
DR   KEGG; mtc:MT1594; -.
DR   PATRIC; fig|83331.31.peg.1715; -.
DR   HOGENOM; CLU_103526_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR019795; Globin_bac-like_CS.
DR   InterPro; IPR001486; Hemoglobin_trunc.
DR   InterPro; IPR016339; Hemoglobin_trunc_I.
DR   Pfam; PF01152; Bac_globin; 1.
DR   PIRSF; PIRSF002030; Globin_Protozoa/Cyanobacteria; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01213; GLOBIN_FAM_2; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   CHAIN           1..136
FT                   /note="Group 1 truncated hemoglobin GlbN"
FT                   /id="PRO_0000427201"
FT   BINDING         81
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   136 AA;  14449 MW;  B75D01A45BC064BB CRC64;
     MGLLSRLRKR EPISIYDKIG GHEAIEVVVE DFYVRVLADD QLSAFFSGTN MSRLKGKQVE
     FFAAALGGPE PYTGAPMKQV HQGRGITMHH FSLVAGHLAD ALTAAGVPSE TITEILGVIA
     PLAVDVTSGE STTAPV