ID   TRHBO_MYCBO             Reviewed;         128 AA.
AC   P0A596; A0A1R3Y192; O53197; X2BKY2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Group 2 truncated hemoglobin GlbO;
DE   AltName: Full=Hemoglobin-like protein HbO;
DE   AltName: Full=Truncated hemoglobin;
DE            Short=trHbO;
GN   Name=glbO; OrderedLocusNames=BQ2027_MB2497;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG;
RA   Pathania R., Ramandee P., Dikshit K.L.;
RT   "Cloning, expression and characterization of an oxygen-binding protein
RT   encoded by glbO locus of Mycobacterium tuberculosis and Mycobacterium
RT   bovis.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC       Note=Binds 1 heme group per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homododecamer. {ECO:0000250}.
CC   -!- PTM: Contains L-DOPA (3',4'-dihydroxyphenylalanine).
CC   -!- SIMILARITY: Belongs to the truncated hemoglobin family. Group II
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF213450; AAF36597.1; -; Genomic_DNA.
DR   EMBL; LT708304; SIU01113.1; -; Genomic_DNA.
DR   RefSeq; NP_856144.1; NC_002945.3.
DR   RefSeq; WP_003412688.1; NC_002945.4.
DR   AlphaFoldDB; P0A596; -.
DR   SMR; P0A596; -.
DR   EnsemblBacteria; SIU01113; SIU01113; BQ2027_MB2497.
DR   GeneID; 45426463; -.
DR   PATRIC; fig|233413.5.peg.2749; -.
DR   OMA; QYWGGPT; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR019795; Globin_bac-like_CS.
DR   InterPro; IPR001486; Hemoglobin_trunc.
DR   Pfam; PF01152; Bac_globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01213; GLOBIN_FAM_2; 1.
PE   3: Inferred from homology;
KW   Heme; Hydroxylation; Iron; Metal-binding; Oxygen transport; Transport.
FT   CHAIN           1..128
FT                   /note="Group 2 truncated hemoglobin GlbO"
FT                   /id="PRO_0000162641"
FT   BINDING         75
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         36
FT                   /note="3',4'-dihydroxyphenylalanine"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        23..36
FT                   /note="Isodityrosine (Tyr-Tyr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  14950 MW;  CEF4CD23907B0CCA CRC64;
     MPKSFYDAVG GAKTFDAIVS RFYAQVAEDE VLRRVYPEDD LAGAEERLRM FLEQYWGGPR
     TYSEQRGHPR LRMRHAPFRI SLIERDAWLR CMHTAVASID SETLDDEHRR ELLDYLEMAA
     HSLVNSPF