TRHB_XENLA
ID TRHB_XENLA Reviewed; 224 AA.
AC Q00643;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Pro-thyrotropin-releasing hormone-B;
DE Short=Pro-TRH-B;
DE AltName: Full=Prothyroliberin type B;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=trh-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=1537407; DOI=10.1016/0014-5793(92)80307-3;
RA Bulant M., Richter K., Kuchler K., Kreil G.;
RT "A cDNA from brain of Xenopus laevis coding for a new precursor of
RT thyrotropin-releasing hormone.";
RL FEBS Lett. 296:292-296(1992).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: This precursor contains seven copies of thyroliberin.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; X64056; CAA45412.1; -; mRNA.
DR PIR; S20382; S20382.
DR RefSeq; NP_001095208.1; NM_001101738.1.
DR AlphaFoldDB; Q00643; -.
DR GeneID; 373666; -.
DR KEGG; xla:373666; -.
DR CTD; 373666; -.
DR Xenbase; XB-GENE-6252873; trh.S.
DR OrthoDB; 1160959at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 373666; Expressed in brain and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..224
FT /note="Pro-thyrotropin-releasing hormone-B"
FT /id="PRO_0000022501"
FT PEPTIDE 75..77
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022502"
FT PEPTIDE 89..91
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022503"
FT PEPTIDE 105..107
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022504"
FT PEPTIDE 119..121
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022505"
FT PEPTIDE 151..153
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022506"
FT PEPTIDE 166..168
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022507"
FT PEPTIDE 191..193
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022508"
FT REGION 86..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 75
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 77
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 89
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 91
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 105
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 107
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 119
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 121
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 151
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 153
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 166
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 168
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 191
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 193
FT /note="Proline amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 224 AA; 26148 MW; 5F65114D5169BF15 CRC64;
MMFLWWLLLL GTAISHKVHS QEQPLLEEDT APADNLDVLE KAKGILIRSF LEGFQEGQQI
NRDLPDAMEM IYKRQHPGKR FQEEIEKRQH PGKRDLEDLQ LSKRQHPGRR YLEDMEKRQH
PGKREEGDWS RGYLTDDSGY LDLFSDVSKR QHPGKRVPDP FFIKRQHPGK RGIEEEDDTE
FENSKEVGKR QHPGKRYDPC EGPNAYNCNS GNLQLDSVEE GWAA
