ID   BUD4_CANGA              Reviewed;        1446 AA.
AC   Q6FJ54;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Bud site selection protein 4;
GN   Name=BUD4; OrderedLocusNames=CAGL0M09086g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for selection of future bud sites. Cooperates with
CC       other bud site selection proteins to recognize a spatial landmark
CC       during mitosis and they subsequently become a landmark for downstream
CC       polarity establishment factors that coordinate budding and cytokinesis.
CC       Involved in the septin organization at the bud neck (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Bud neck. Note=Localizes to two distinct rings on
CC       either side of the mother-bud neck. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BUD4 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62716.1; -; Genomic_DNA.
DR   RefSeq; XP_449740.1; XM_449740.1.
DR   AlphaFoldDB; Q6FJ54; -.
DR   STRING; 5478.XP_449740.1; -.
DR   EnsemblFungi; CAG62716; CAG62716; CAGL0M09086g.
DR   GeneID; 2891302; -.
DR   KEGG; cgr:CAGL0M09086g; -.
DR   CGD; CAL0136477; CAGL0M09086g.
DR   VEuPathDB; FungiDB:CAGL0M09086g; -.
DR   eggNOG; ENOG502REBM; Eukaryota.
DR   HOGENOM; CLU_004727_0_0_1; -.
DR   InParanoid; Q6FJ54; -.
DR   OMA; MLVKHNT; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Reference proteome.
FT   CHAIN           1..1446
FT                   /note="Bud site selection protein 4"
FT                   /id="PRO_0000330079"
FT   DOMAIN          1314..1425
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          69..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          823..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1025..1044
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..97
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1026..1041
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1446 AA;  162081 MW;  572E2D627D4C57F4 CRC64;
     MEAETTVDSL LKEIDMEMEM QSGNDVAQSN GYLLPLQEIG DETMDMLVQY NTENNANSNV
     NANANANANQ WNKVDDPQDL LPMENNYDDD EEQGDESDTT NLLSGNKHLT EEESEQVLVD
     SKNLVLPPSS SKSNLINNLK QVVEDEVSDS QLSNDMDDTR TLNFSVKGTE PLLADELQDK
     EPDMIEVSTI YDGPDMISMA DDSDTEDIDL LSKAKKPVSP SKIPITNAQT INYFKDAPVE
     DAKLQTVPDD IPLETKQTTV SNDILSNVET LLPPTLERPS FVISNLKEAS QSVENLGFPD
     YEEDSQSEQE TSVLHHTPTD FHAHEFEVFA TELPDINVTP SIKPIDIDNN CEHENRLVSE
     EESKGVISSV PENENLPAVK SNPSSNSISD MLEIRQENKL DETLNMIDHQ LSSNKSIDSV
     KTVSDNNISK SANDGSVEDV ADSGKETSDI ARNIEESHNS LINLTSGNNF DQSMHNDLIE
     ESNTRVNVTE SDITASEDSF NGSHDQNSSL NNLTKNDNGI QQNLEDNHTG IQPEMVVPEE
     VTTTLPEVNI LPASENMLEN TSESEISVQF LQNRDNEDKV SSDPQLEENI RSTETVMNTQ
     ETFEPKPAKK NQYTDREIEV LNSQKDISEA TDNSAVNSRI SSSASNFTPV LPPLPKLEKL
     SIDDPFDDEF ETSNESMQMK NSVKPTDYLS IWHLQEQTTK AVSPALSSNS QFSYNSNSTK
     SSVASPVPAT AFKFKPKIVS RSKYYYPDNN IQQEQSMDFI YTKLPSILDP MRRNTINSKK
     IRQTVIDKRK SHPSFSVDEG NTITEVNIEP EVKVQPISIE NDSSSLKANN QDDNESCSSG
     SQAFVTPSAT MDNFDSQFNE LGTSFENDLE NVLNYFDKDI NTNTSSDLIE ETTTKNQALP
     TSKVWSESVD YSLPTGEEPN VDHNIMKKLL NTENSELNEC RSDQEHHIID NAGLGIWRST
     ANDIATGNVD MFALNGRDIS ISKSEMTNDI DMGIFSDKKS LVHTPELSPV KSTHVGSPFK
     VISPKKNTQK DLKDGTTAEK RVSSESEAAQ ISIMSAVGEI TNKDTAVVDD ASNKDNIDAG
     QVGNEGEPIV DKGLLYLHLQ GTTKLSLAGI NAHHPKYSIE FDNGKNVVRT DWTELDSRGT
     ISLNKEFEIP IDQSINKLII TLMIKYTRLT NELVEVTKRI PIGKKFPFGK MKYRTETQFV
     ERSTVKDEWD YLFARDGSFG RCEILLDESL FEKIRFKEQD LSFDLLNKWS RLQNNSSSKV
     TQEALYDLPR RPAYKVGSLK VKGCFLERVS NDEKFPVSLK KAKSIVEKYR SQQDITKEGY
     LLQEGGDLSS QMKNRFFKLN GVELVGYHEV SMKPKIRINM LKVVKVIGKD DVVTGKDNVR
     NFTTWVLMND CFQLVFDDGE VITFSDESSL ADEQSWYMKL KEVVELNAFH QPWVKRFSEN
     MIINDI