ID   TRHP_HELPY              Reviewed;         422 AA.
AC   P56113;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=tRNA hydroxylation protein P {ECO:0000250|UniProtKB:P76403};
DE            EC=3.4.-.- {ECO:0000305};
DE   Flags: Precursor;
GN   Name=trhP {ECO:0000250|UniProtKB:P76403}; OrderedLocusNames=HP_0169;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Involved in prephenate-dependent formation of 5-
CC       hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first
CC       step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.
CC       {ECO:0000250|UniProtKB:P76403}.
CC   -!- SIMILARITY: Belongs to the peptidase U32 family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07235.1; -; Genomic_DNA.
DR   PIR; A64541; A64541.
DR   RefSeq; NP_206968.1; NC_000915.1.
DR   RefSeq; WP_001077422.1; NC_018939.1.
DR   AlphaFoldDB; P56113; -.
DR   STRING; 85962.C694_00835; -.
DR   MEROPS; U32.002; -.
DR   PaxDb; P56113; -.
DR   EnsemblBacteria; AAD07235; AAD07235; HP_0169.
DR   KEGG; hpy:HP_0169; -.
DR   PATRIC; fig|85962.47.peg.182; -.
DR   eggNOG; COG0826; Bacteria.
DR   OMA; YGGVSHF; -.
DR   PhylomeDB; P56113; -.
DR   PHI-base; PHI:6964; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR001539; Peptidase_U32.
DR   Pfam; PF01136; Peptidase_U32; 1.
DR   PROSITE; PS01276; PEPTIDASE_U32; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Reference proteome; Signal; tRNA processing.
FT   SIGNAL          1..58
FT                   /evidence="ECO:0000255"
FT   CHAIN           59..422
FT                   /note="tRNA hydroxylation protein P"
FT                   /id="PRO_0000028526"
SQ   SEQUENCE   422 AA;  47275 MW;  C2CDADA9480A77A1 CRC64;
     MNQVELLSPA GNLKKLKIAL NYGADAVYGG VSHFSLRNRA GKEFTLETFK EGIDYAHALN
     KKVYATINGF PFNSQLKLLE EHIDKMAELE PDAFIIAAPG VVKLALKIAP HIPIHLSTQA
     NVLNLLDAQV FYDLGVKRIV CARELSLNDA IEIKKALPNL ELEIFVHGSM CFAFSGRCLI
     SALQKGRVPN RGSCANDCRF DYEYYVKNPD NGVMMRLVEE EGVGTHIFNA KDLNLSGHIA
     EILSSNAISA LKIEGRTKSS YYAAQTTRIY RLAVDDFYHN TLKPSFYASE LNTLKNRGFT
     DGYLMRRPFE RLDTQNHQTA ISEGDFQVNG EITEDGRFFA CKFTTTTNTA YEIIAPKNAA
     ITPIVNEIGK IYTFEKRSYL VLYKILLENN TELETIHSGN VNLVRLPAPL PAFSFLRTQV
     RV