TRH_CARAU
ID TRH_CARAU Reviewed; 231 AA.
AC Q5KT10;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Pro-thyrotropin-releasing hormone;
DE Short=Pro-TRH;
DE AltName: Full=Prothyroliberin;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=trh;
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15707606; DOI=10.1016/j.ygcen.2004.11.011;
RA Aoki Y., Takahashi M., Masuda T., Tsukamoto T., Iigo M., Yanagisawa T.;
RT "Molecular cloning of prepro-thyrotropin-releasing hormone cDNAs from the
RT common carp Cyprinus carpio and goldfish Carassius auratus.";
RL Gen. Comp. Endocrinol. 141:84-92(2005).
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; AB179819; BAD83782.1; -; mRNA.
DR AlphaFoldDB; Q5KT10; -.
DR Ensembl; ENSCART00000101788; ENSCARP00000092325; ENSCARG00000045809.
DR Proteomes; UP000515129; Genome assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 2.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..231
FT /note="Pro-thyrotropin-releasing hormone"
FT /id="PRO_0000041904"
FT PEPTIDE 70..72
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041905"
FT PEPTIDE 76..78
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041906"
FT PEPTIDE 97..99
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041907"
FT PEPTIDE 114..116
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041908"
FT PEPTIDE 140..142
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041909"
FT PEPTIDE 154..156
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041910"
FT PEPTIDE 175..177
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041911"
FT PEPTIDE 213..215
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041912"
FT REGION 50..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 70
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 72
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 76
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 78
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 97
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 99
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 114
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 116
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 140
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 142
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 154
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 156
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 175
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 177
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 213
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 215
FT /note="Proline amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 231 AA; 26597 MW; 02112F75D1BC1A5D CRC64;
MRAACVIILA SLTVFMSPGL QCQPLAGEGD PSLDELFQRA ESLLIRSILT QTEDENHGDG
EQTEWLEKRQ HPGKRQHPGK REDTDYEDEA AALQKRQHPG KREEEEDSAR LRRQHPGKRL
SLEHMMLEEP TAQSELAKRQ HPGRRYLMLL HKRQHPGRRE LHEAAGDFSD LAKRQHPGKR
LCEDWDVTGC DQASILLELL DNVNKSRAEE KRQHPGKRFA LEDELTEQES L
