TRH_CHICK
ID TRH_CHICK Reviewed; 260 AA.
AC Q6ZXC3; Q5DW25;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Pro-thyrotropin-releasing hormone;
DE Short=Pro-TRH;
DE AltName: Full=Prothyroliberin;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Contains:
DE RecName: Full=Thyroliberin-like;
DE Flags: Precursor;
GN Name=TRH;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Ross; TISSUE=Brain;
RX PubMed=16079264; DOI=10.1677/joe.1.06161;
RA Vandenborne K., Roelens S.A., Darras V.M., Kuehn E.R., Van der Geyten S.;
RT "Cloning and hypothalamic distribution of the chicken thyrotropin-releasing
RT hormone precursor cDNA.";
RL J. Endocrinol. 186:387-396(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Aoki Y., Masuda T., Yasuo S., Yoshimura T., Ebihara S., Iigo M.,
RA Yanagisawa T.;
RT "Molecular cloning of prepro-thyrotropin-releasing hormone cDNA and its
RT expression in the brain of chicken (Gallus gallus).";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; AJ703806; CAG28319.2; -; mRNA.
DR EMBL; AB205116; BAD90101.1; -; mRNA.
DR RefSeq; NP_001025554.1; NM_001030383.2.
DR RefSeq; XP_015148528.1; XM_015293042.1.
DR AlphaFoldDB; Q6ZXC3; -.
DR SMR; Q6ZXC3; -.
DR STRING; 9031.ENSGALP00000042342; -.
DR PaxDb; Q6ZXC3; -.
DR Ensembl; ENSGALT00000013835; ENSGALP00000013820; ENSGALG00000008490.
DR GeneID; 414344; -.
DR KEGG; gga:414344; -.
DR CTD; 7200; -.
DR VEuPathDB; HostDB:geneid_414344; -.
DR eggNOG; ENOG502RWH0; Eukaryota.
DR GeneTree; ENSGT00390000016951; -.
DR HOGENOM; CLU_101029_0_0_1; -.
DR InParanoid; Q6ZXC3; -.
DR OMA; RYLMYKH; -.
DR OrthoDB; 1160959at2759; -.
DR PhylomeDB; Q6ZXC3; -.
DR TreeFam; TF332073; -.
DR Reactome; R-GGA-375276; Peptide ligand-binding receptors.
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR PRO; PR:Q6ZXC3; -.
DR Proteomes; UP000000539; Chromosome 12.
DR Bgee; ENSGALG00000008490; Expressed in testis and 4 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0042755; P:eating behavior; IBA:GO_Central.
DR GO; GO:0001692; P:histamine metabolic process; IBA:GO_Central.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; IBA:GO_Central.
DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; IBA:GO_Central.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IBA:GO_Central.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..260
FT /note="Pro-thyrotropin-releasing hormone"
FT /id="PRO_0000041888"
FT PEPTIDE 79..81
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041889"
FT PEPTIDE 93..95
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041890"
FT PEPTIDE 113..115
FT /note="Thyroliberin-like"
FT /id="PRO_0000041891"
FT PEPTIDE 134..136
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041892"
FT PEPTIDE 163..165
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041893"
FT PEPTIDE 246..248
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041895"
FT REGION 72..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 81
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 93
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 95
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 113
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 115
FT /note="Leucine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 134
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 136
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 163
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 165
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 246
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 248
FT /note="Proline amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 260 AA; 30337 MW; 00BEDB2CC65814E0 CRC64;
MPSIQLPVLL LCLTLSGVCL NGRQFPPELS ENMGRSSLDD ILQRSGSHML QSVLKKVEKK
EEMNKELNMP LPQWLSKRQH PGKRYISDPE KRQHPGKRDV EEKASFGDIQ KRQHLGKTEV
EGYLVNYLEL KKRQHPGRRS LWDQSTDISS SQLTYLNELS KRQHPGRRYL MYKHQHPSKR
GWNDELDLSD QNWEKHQQFG NRDRDSDSPD YTGPCDLQQS AICNKDSLLL DLAEKFSKEG
VEEKHQHPGR RSAWENETEE
