ID   TRH_CYPCA               Reviewed;         187 AA.
AC   Q5KT11;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Pro-thyrotropin-releasing hormone;
DE            Short=Pro-TRH;
DE   AltName: Full=Prothyroliberin;
DE   Contains:
DE     RecName: Full=Thyrotropin-releasing hormone;
DE              Short=TRH;
DE     AltName: Full=Protirelin;
DE     AltName: Full=TSH-releasing factor;
DE     AltName: Full=Thyroliberin;
DE     AltName: Full=Thyrotropin-releasing factor;
DE              Short=TRF;
DE   Flags: Precursor;
GN   Name=trh;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15707606; DOI=10.1016/j.ygcen.2004.11.011;
RA   Aoki Y., Takahashi M., Masuda T., Tsukamoto T., Iigo M., Yanagisawa T.;
RT   "Molecular cloning of prepro-thyrotropin-releasing hormone cDNAs from the
RT   common carp Cyprinus carpio and goldfish Carassius auratus.";
RL   Gen. Comp. Endocrinol. 141:84-92(2005).
CC   -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC       anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC       the central and peripheral nervous systems. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR   EMBL; AB179818; BAD83781.1; -; mRNA.
DR   AlphaFoldDB; Q5KT11; -.
DR   SMR; Q5KT11; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR   InterPro; IPR008857; TRH.
DR   Pfam; PF05438; TRH; 3.
DR   PIRSF; PIRSF001795; TRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..187
FT                   /note="Pro-thyrotropin-releasing hormone"
FT                   /id="PRO_0000041913"
FT   PEPTIDE         65..67
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000041914"
FT   PEPTIDE         80..82
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000041915"
FT   PEPTIDE         106..108
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000041916"
FT   PEPTIDE         120..122
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000041917"
FT   PEPTIDE         136..138
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000041918"
FT   PEPTIDE         171..173
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000041919"
FT   REGION          49..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         65
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         67
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         80
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         82
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         106
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         108
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         120
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         122
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         136
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         138
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         171
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         173
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  21286 MW;  8D560657238DCF91 CRC64;
     MRAACVILLA SLTVSVSPGG QAQALPGEGD PSLDELLQLL RSMLTQMEDE NHANGEQTEW
     LEKRQHPGKR EEDGGRLRRQ HPGKRLSLEQ VMLEEPSEQS ELSKRQHPGK RYLMLLHKRQ
     HPGRRELQEA SLAKRQHPGK RLCEDWSETG CDPASVLLEL LDRSGAEEKR QHPGKRLELE
     DDLTEQE