TRH_DANRE
ID TRH_DANRE Reviewed; 199 AA.
AC Q5EDF9; Q503T3;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Pro-thyrotropin-releasing hormone;
DE Short=Pro-TRH;
DE AltName: Full=Prothyroliberin;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=trh;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhang D., Jiang S.;
RT "Molecular cloning and characterization of the thyrotropin-releasing
RT hormone from zebrafish, Danio rerio.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; AY903312; AAW82913.1; -; mRNA.
DR EMBL; BC095193; AAH95193.1; -; mRNA.
DR RefSeq; NP_001012365.2; NM_001012365.2.
DR AlphaFoldDB; Q5EDF9; -.
DR STRING; 7955.ENSDARP00000021167; -.
DR PaxDb; Q5EDF9; -.
DR GeneID; 266721; -.
DR KEGG; dre:266721; -.
DR CTD; 7200; -.
DR ZFIN; ZDB-GENE-020930-1; trh.
DR eggNOG; ENOG502RWH0; Eukaryota.
DR InParanoid; Q5EDF9; -.
DR OrthoDB; 1160959at2759; -.
DR PhylomeDB; Q5EDF9; -.
DR Reactome; R-DRE-375276; Peptide ligand-binding receptors.
DR Reactome; R-DRE-416476; G alpha (q) signalling events.
DR PRO; PR:Q5EDF9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0042755; P:eating behavior; IBA:GO_Central.
DR GO; GO:0001692; P:histamine metabolic process; IBA:GO_Central.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; IBA:GO_Central.
DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; IBA:GO_Central.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IBA:GO_Central.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 2.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..199
FT /note="Pro-thyrotropin-releasing hormone"
FT /id="PRO_0000041896"
FT PEPTIDE 64..66
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041897"
FT PEPTIDE 70..72
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041898"
FT PEPTIDE 91..93
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041899"
FT PEPTIDE 117..119
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041900"
FT PEPTIDE 131..133
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041901"
FT PEPTIDE 152..154
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041902"
FT PEPTIDE 183..185
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041903"
FT REGION 48..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 66
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 70
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 72
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 91
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 93
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 117
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 119
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 131
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 133
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 152
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 154
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 183
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 185
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT CONFLICT 58
FT /note="E -> D (in Ref. 2; AAH95193)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="E -> K (in Ref. 2; AAH95193)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="P -> R (in Ref. 2; AAH95193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 22739 MW; 0F83A84F3E3B4AAC CRC64;
MRAVCVFVLA CVAVSGAPGV RGQDGPAEEE LFQRAEDLLL RSILTQMEEQ NSENDQPEWM
EKRQHPGKRQ HPGKREEDLE PEVEMERWRR QHPGKRAPLD LGMLEDPTAL SELSKRQHPG
KRYLMLLHKR QHPGRRELQE ADGDSAELEK RQHPGKRRCE GWADAGCGLL ELLDTSGAPE
KRQHPGRRAE LEDELPGLE
