TRH_MOUSE
ID TRH_MOUSE Reviewed; 256 AA.
AC Q62361; Q7TMT4;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Pro-thyrotropin-releasing hormone;
DE Short=Pro-TRH;
DE AltName: Full=Prothyroliberin;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=Trh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ;
RX PubMed=1323011; DOI=10.1016/0169-328x(92)90020-c;
RA Satoh T., Yamada M., Monden T., Iizuka M., Mori M.;
RT "Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone
RT (TRH) cDNA and tissue distribution of its mRNA.";
RL Brain Res. Mol. Brain Res. 14:131-135(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129/Sv X 129/SvCp;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Specifically expressed in hypothalamus and testis.
CC {ECO:0000269|PubMed:1323011}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; X59387; CAA42030.1; -; mRNA.
DR EMBL; BC053493; AAH53493.1; -; mRNA.
DR CCDS; CCDS20375.1; -.
DR PIR; A43955; RTMST.
DR RefSeq; NP_033452.2; NM_009426.3.
DR AlphaFoldDB; Q62361; -.
DR STRING; 10090.ENSMUSP00000006046; -.
DR iPTMnet; Q62361; -.
DR PhosphoSitePlus; Q62361; -.
DR PaxDb; Q62361; -.
DR PeptideAtlas; Q62361; -.
DR PRIDE; Q62361; -.
DR ProteomicsDB; 259182; -.
DR Antibodypedia; 33301; 147 antibodies from 26 providers.
DR DNASU; 22044; -.
DR Ensembl; ENSMUST00000006046; ENSMUSP00000006046; ENSMUSG00000005892.
DR GeneID; 22044; -.
DR KEGG; mmu:22044; -.
DR UCSC; uc009cyw.2; mouse.
DR CTD; 7200; -.
DR MGI; MGI:98823; Trh.
DR VEuPathDB; HostDB:ENSMUSG00000005892; -.
DR eggNOG; ENOG502RWH0; Eukaryota.
DR GeneTree; ENSGT00390000016951; -.
DR HOGENOM; CLU_101029_0_0_1; -.
DR InParanoid; Q62361; -.
DR OMA; RYLMYKH; -.
DR OrthoDB; 1160959at2759; -.
DR PhylomeDB; Q62361; -.
DR TreeFam; TF332073; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 22044; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q62361; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q62361; protein.
DR Bgee; ENSMUSG00000005892; Expressed in endodermal part of digestive tract and 59 other tissues.
DR Genevisible; Q62361; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; ISO:MGI.
DR GO; GO:0007628; P:adult walking behavior; IGI:MGI.
DR GO; GO:0042755; P:eating behavior; ISO:MGI.
DR GO; GO:0001692; P:histamine metabolic process; ISO:MGI.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR GO; GO:2000252; P:negative regulation of feeding behavior; ISO:MGI.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; ISO:MGI.
DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; ISO:MGI.
DR GO; GO:0032024; P:positive regulation of insulin secretion; ISO:MGI.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 2.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..256
FT /note="Pro-thyrotropin-releasing hormone"
FT /id="PRO_0000022516"
FT PEPTIDE 77..79
FT /note="Thyrotropin-releasing hormone"
FT /evidence="ECO:0000250"
FT /id="PRO_0000022517"
FT PEPTIDE 109..111
FT /note="Thyrotropin-releasing hormone"
FT /evidence="ECO:0000250"
FT /id="PRO_0000022518"
FT PEPTIDE 154..156
FT /note="Thyrotropin-releasing hormone"
FT /evidence="ECO:0000250"
FT /id="PRO_0000022519"
FT PEPTIDE 172..174
FT /note="Thyrotropin-releasing hormone"
FT /evidence="ECO:0000250"
FT /id="PRO_0000022520"
FT PEPTIDE 203..205
FT /note="Thyrotropin-releasing hormone"
FT /evidence="ECO:0000250"
FT /id="PRO_0000022521"
FT REGION 76..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 111
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 156
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 174
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 205
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT CONFLICT 28
FT /note="A -> G (in Ref. 1; CAA42030)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="E -> L (in Ref. 2; AAH53493)"
FT /evidence="ECO:0000305"
FT CONFLICT 89
FT /note="Missing (in Ref. 2; AAH53493)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 256 AA; 29195 MW; 22ED0AD6A4FC5A2C CRC64;
MQGPWLMMAL ALIFVLTGIP KSCALLEAAQ EEGAVTPDLP GLEKVQVRPE RRFLRKDLQR
VRGDLGAALD SWITKRQHPG KREEKEEDVE AEERGDLGEV GAWRPHKRQH PGRRANQDKD
SWSDEGDSDW LPPSWLPDFF LDSWFSDAPQ VKRQHPGRRS FPWMESDVTK RQHPGRRFID
PELQRSWEET EGEEGGLMPE KRQHPGKRAV GHPCGPQGIC GQTGLLQLLG DLSRGQETLA
KQTPQLEAWV REPLEE
