ID   TRH_NOTVI               Reviewed;           3 AA.
AC   P62971; P01151;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 29.
DE   RecName: Full=Thyrotropin-releasing hormone;
DE            Short=TRH;
DE   AltName: Full=Protirelin;
DE   AltName: Full=TSH-releasing factor;
DE   AltName: Full=Thyroliberin;
DE   AltName: Full=Thyrotropin-releasing factor;
DE            Short=TRF;
OS   Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Notophthalmus.
OX   NCBI_TaxID=8316;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT PRO-3.
RC   TISSUE=Brain;
RX   PubMed=4214528; DOI=10.1111/j.1471-4159.1974.tb06048.x;
RA   Grimm-Joergensen Y., McKelvy J.F.;
RT   "Biosynthesis of thyrotropin releasing factor by newt (Triturus
RT   viridescens) brain in vitro. Isolation and characterization of thyrotropin
RT   releasing factor.";
RL   J. Neurochem. 23:471-478(1974).
CC   -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC       anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC       the central and peripheral nervous systems.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR   PIR; A92971; A92971.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..3
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000044564"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:4214528"
FT   MOD_RES         3
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:4214528"
SQ   SEQUENCE   3 AA;  380 MW;  7761F6B000000000 CRC64;
     QHP