TRH_ONCNE
ID TRH_ONCNE Reviewed; 258 AA.
AC Q8QFQ9;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Pro-thyrotropin-releasing hormone-A;
DE Short=Pro-TRH-A;
DE AltName: Full=Prothyroliberin type A;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=trha;
OS Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8023;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8877818; DOI=10.1111/j.1365-2826.1996.tb00706.x;
RA Ohide A., Ando H., Yanagisawa T., Urano A.;
RT "Hydropathy profiles of predicted thyrotropin-releasing hormone precursors
RT are highly conserved despite low similarity of primary structures.";
RL J. Neuroendocrinol. 8:695-701(1996).
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; AB082956; BAB88661.1; -; mRNA.
DR AlphaFoldDB; Q8QFQ9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..258
FT /note="Pro-thyrotropin-releasing hormone-A"
FT /id="PRO_0000041920"
FT PEPTIDE 78..80
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041921"
FT PEPTIDE 92..94
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041922"
FT PEPTIDE 112..114
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041923"
FT PEPTIDE 131..133
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041924"
FT PEPTIDE 156..158
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041925"
FT PEPTIDE 170..172
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041926"
FT PEPTIDE 193..195
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041927"
FT PEPTIDE 242..244
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000041928"
FT REGION 84..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 78
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 80
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 92
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 94
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 112
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 114
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 131
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 133
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 156
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 158
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 170
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 172
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 193
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 195
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 242
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 244
FT /note="Proline amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 258 AA; 29645 MW; ABE930FD9E970C0C CRC64;
MKSACLIILA SLVVCNLTLA RGQGIPAEEE TGDRQTIDDI ILQRAESLLL RSILKNIGDE
DGANEGLTSQ PEWLVKRQHP GKRYQEELEK RQHPGKREED EDEDYDEVQK RQHPGKREDE
FDSFVELQRR QHPGKRLILE QITENPAFLS ELSKRQHPGK RYVMYYSKRQ HPGRREVDDE
SDAGDLRELE KRQHPGKRYL DNTSPDLGAN SPCDVLDPGC SKANLLLQLL DNVNKSRAEK
RQHPGKRSAP VEDLTEQE
