ID   TRH_PIG                 Reviewed;           3 AA.
AC   P62968; P01151;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-DEC-2020, entry version 35.
DE   RecName: Full=Thyrotropin-releasing hormone;
DE            Short=TRH;
DE   AltName: Full=Protirelin;
DE   AltName: Full=TSH-releasing factor;
DE   AltName: Full=Thyroliberin;
DE   AltName: Full=Thyrotropin-releasing factor;
DE            Short=TRF;
GN   Name=TRH;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PRO-3.
RC   TISSUE=Hypothalamus;
RX   PubMed=4984938; DOI=10.1021/bi00807a008;
RA   Nair R.M.G., Barrett J.F., Bowers C.Y., Schally A.V.;
RT   "Structure of porcine thyrotropin releasing hormone.";
RL   Biochemistry 9:1103-1106(1970).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=4982117; DOI=10.1016/0006-291x(69)90868-7;
RA   Boler J., Enzmann F., Folkers K., Bowers C.Y., Schally A.V.;
RT   "The identity of chemical and hormonal properties of the thyrotropin
RT   releasing hormone and pyroglutamyl-histidyl-proline amide.";
RL   Biochem. Biophys. Res. Commun. 37:705-710(1969).
CC   -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC       anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC       the central and peripheral nervous systems.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..3
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000044561"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P62969"
FT   MOD_RES         3
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:4984938"
SQ   SEQUENCE   3 AA;  380 MW;  7761F6B000000000 CRC64;
     QHP