TRH_RAT
ID TRH_RAT Reviewed; 255 AA.
AC P01150;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Pro-thyrotropin-releasing hormone;
DE Short=Pro-TRH;
DE AltName: Full=Prothyroliberin;
DE Contains:
DE RecName: Full=Thyrotropin-releasing hormone;
DE Short=TRH;
DE AltName: Full=Protirelin;
DE AltName: Full=TSH-releasing factor;
DE AltName: Full=Thyroliberin;
DE AltName: Full=Thyrotropin-releasing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=Trh;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3079917; DOI=10.1126/science.3079917;
RA Lechan R.M., Wu P., Jackson I.M.D., Wolf H., Cooperman S., Mandel G.,
RA Goodman R.H.;
RT "Thyrotropin-releasing hormone precursor: characterization in rat brain.";
RL Science 231:159-161(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2903153; DOI=10.1016/s0021-9258(18)37433-7;
RA Lee S.L., Stewart K., Goodman R.H.;
RT "Structure of the gene encoding rat thyrotropin releasing hormone.";
RL J. Biol. Chem. 263:16604-16609(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2497670; DOI=10.1111/j.1749-6632.1989.tb46629.x;
RA Lee S.L., Sevarino K., Roos B.A., Goodman R.H.;
RT "Characterization and expression of the gene-encoding rat thyrotropin-
RT releasing hormone (TRH).";
RL Ann. N. Y. Acad. Sci. 553:14-28(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mandel G., Goodman R.H.;
RT "Using the brain to screen cloned genes.";
RL Trends Neurosci. 10:101-104(1987).
RN [5]
RP PROTEOLYTIC PROCESSING, AND PYROGLUTAMATE FORMATION AT GLN-154 AND GLN-172.
RX PubMed=2119297; DOI=10.1210/endo-127-4-1978;
RA Bulant M., Beauvillain J.-C., Delfour A., Vaudry H., Nicolas P.;
RT "Processing of thyrotropin-releasing hormone (TRH) prohormone in the rat
RT olfactory bulb generates novel TRH-related peptides.";
RL Endocrinology 127:1978-1985(1990).
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
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DR EMBL; M12138; AAA42275.1; -; mRNA.
DR EMBL; M23632; AAA65750.2; -; Genomic_DNA.
DR EMBL; M23643; AAA65750.2; JOINED; Genomic_DNA.
DR EMBL; M27465; AAA42239.1; -; Genomic_DNA.
DR EMBL; M27464; AAA42239.1; JOINED; Genomic_DNA.
DR EMBL; M36317; AAA42276.1; -; mRNA.
DR PIR; A31773; RHRTT.
DR RefSeq; NP_037178.1; NM_013046.3.
DR RefSeq; XP_006236961.1; XM_006236899.2.
DR AlphaFoldDB; P01150; -.
DR STRING; 10116.ENSRNOP00000015944; -.
DR BindingDB; P01150; -.
DR PaxDb; P01150; -.
DR Ensembl; ENSRNOT00000015944; ENSRNOP00000015944; ENSRNOG00000011824.
DR GeneID; 25569; -.
DR KEGG; rno:25569; -.
DR CTD; 7200; -.
DR RGD; 3903; Trh.
DR eggNOG; ENOG502RWH0; Eukaryota.
DR GeneTree; ENSGT00390000016951; -.
DR HOGENOM; CLU_101029_0_0_1; -.
DR InParanoid; P01150; -.
DR OMA; RYLMYKH; -.
DR OrthoDB; 1160959at2759; -.
DR PhylomeDB; P01150; -.
DR TreeFam; TF332073; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P01150; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000011824; Expressed in testis and 8 other tissues.
DR ExpressionAtlas; P01150; baseline and differential.
DR Genevisible; P01150; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0030141; C:secretory granule; IDA:RGD.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IDA:RGD.
DR GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR GO; GO:0042755; P:eating behavior; IDA:RGD.
DR GO; GO:0001692; P:histamine metabolic process; IDA:RGD.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR GO; GO:2000252; P:negative regulation of feeding behavior; IDA:RGD.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; IDA:RGD.
DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; IDA:RGD.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IDA:RGD.
DR GO; GO:0009409; P:response to cold; IEP:RGD.
DR GO; GO:0051412; P:response to corticosterone; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0009749; P:response to glucose; IEP:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR InterPro; IPR008857; TRH.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT CHAIN 25..255
FT /note="Pro-thyrotropin-releasing hormone"
FT /id="PRO_0000022522"
FT PEPTIDE 77..79
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022523"
FT PEPTIDE 109..111
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022524"
FT PEPTIDE 154..156
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022525"
FT PEPTIDE 172..174
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022526"
FT PEPTIDE 202..204
FT /note="Thyrotropin-releasing hormone"
FT /id="PRO_0000022527"
FT REGION 76..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 111
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 154
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:2119297"
FT MOD_RES 156
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 172
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:2119297"
FT MOD_RES 174
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT MOD_RES 204
FT /note="Proline amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 255 AA; 29284 MW; 440DCCEADC0A22EB CRC64;
MPGPWLLLAL ALIFTLTGIP ESCALPEAAQ EEGAVTPDLP GLENVQVRPE RRFLWKDLQR
VRGDLGAALD SWITKRQHPG KREEEEKDIE AEERGDLGEG GAWRLHKRQH PGRRANQDKY
SWADEEDSDW MPRSWLPDFF LDSWFSDVPQ VKRQHPGRRS FPWMESDVTK RQHPGRRFID
PELQRSWEEK EGEGVLMPEK RQHPGKRALG HPCGPQGTCG QTGLLQLLGD LSRGQETLVK
QSPQVEPWDK EPLEE
