ID   TRH_SHEEP               Reviewed;           3 AA.
AC   P62969; P01151;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 31.
DE   RecName: Full=Thyrotropin-releasing hormone;
DE            Short=TRH;
DE   AltName: Full=Protirelin;
DE   AltName: Full=TSH-releasing factor;
DE   AltName: Full=Thyroliberin;
DE   AltName: Full=Thyrotropin-releasing factor;
DE            Short=TRF;
GN   Name=TRH;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT PRO-3.
RC   TISSUE=Hypothalamus;
RA   Desiderio D.M. Jr., Burgus R., Dunn T.F., Vale W., Guillemin R., Ward D.N.;
RT   "The elucidation of the primary structure of the hypothalamic thyroid
RT   stimulating hormone releasing factor of ovine origin by means of mass
RT   spectrometry.";
RL   Org. Mass Spectrom. 5:221-228(1971).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=4985794; DOI=10.1038/226321a0;
RA   Burgus R., Dunn T.F., Desiderio D.M., Ward D.N., Vale W., Guillemin R.;
RT   "Characterization of ovine hypothalamic hypophysiotropic TSH-releasing
RT   factor.";
RL   Nature 226:321-325(1970).
CC   -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC       anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC       the central and peripheral nervous systems.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TRH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A93750; RHSHT.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..3
FT                   /note="Thyrotropin-releasing hormone"
FT                   /id="PRO_0000044562"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         3
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   3 AA;  380 MW;  7761F6B000000000 CRC64;
     QHP