ID   TRI10_FUSSP             Reviewed;         420 AA.
AC   Q9C1B5;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Trichothecene biosynthesis transcription regulator TRI10 {ECO:0000303|PubMed:11679358};
DE   AltName: Full=Core trichothecene cluster (CTC) protein 10 {ECO:0000303|PubMed:11352533};
GN   Name=TRI10 {ECO:0000303|PubMed:11352533};
OS   Fusarium sporotrichioides.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 24631 / NRRL 3299;
RX   PubMed=11679358; DOI=10.1128/aem.67.11.5294-5302.2001;
RA   Tag A.G., Garifullina G.F., Peplow A.W., Ake C. Jr., Phillips T.D.,
RA   Hohn T.M., Beremand M.N.;
RT   "A novel regulatory gene, Tri10, controls trichothecene toxin production
RT   and gene expression.";
RL   Appl. Environ. Microbiol. 67:5294-5302(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND IDENTIFICATION.
RC   STRAIN=ATCC 24631 / NRRL 3299;
RX   PubMed=11352533; DOI=10.1006/fgbi.2001.1256;
RA   Brown D.W., McCormick S.P., Alexander N.J., Proctor R.H., Desjardins A.E.;
RT   "A genetic and biochemical approach to study trichothecene diversity in
RT   Fusarium sporotrichioides and Fusarium graminearum.";
RL   Fungal Genet. Biol. 32:121-133(2001).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 24631 / NRRL 3299;
RX   PubMed=12732543; DOI=10.1128/aem.69.5.2731-2736.2003;
RA   Peplow A.W., Tag A.G., Garifullina G.F., Beremand M.N.;
RT   "Identification of new genes positively regulated by Tri10 and a regulatory
RT   network for trichothecene mycotoxin production.";
RL   Appl. Environ. Microbiol. 69:2731-2736(2003).
CC   -!- FUNCTION: Transcriptional activator of all of the trichothecene
CC       biosynthesis genes (PubMed:11679358, PubMed:12732543). Acts upstream of
CC       the cluster-encoded transcription factor TRI6 and is necessary for full
CC       expression of both the other trichothecene genes and the genes for the
CC       primary metabolic pathway that precedes the trichothecene biosynthetic
CC       pathway (PubMed:11679358, PubMed:12732543).
CC       {ECO:0000269|PubMed:11679358, ECO:0000269|PubMed:12732543}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Abolishes T-2 toxin production and dramatically
CC       decreases the transcript accumulation for trichothecene genes and an
CC       apparent farnesyl pyrophosphate synthetase (FPPS) gene
CC       (PubMed:11679358, PubMed:12732543). {ECO:0000269|PubMed:11679358,
CC       ECO:0000269|PubMed:12732543}.
CC   -!- SIMILARITY: Belongs to the TRI10 transcription regulator family.
CC       {ECO:0000305}.
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DR   EMBL; AF359360; AAK33069.1; -; Genomic_DNA.
DR   EMBL; AF364179; AAK53383.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9C1B5; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021858; Fun_TF.
DR   Pfam; PF11951; Fungal_trans_2; 1.
PE   3: Inferred from homology;
KW   Nucleus.
FT   CHAIN           1..420
FT                   /note="Trichothecene biosynthesis transcription regulator
FT                   TRI10"
FT                   /id="PRO_0000442372"
SQ   SEQUENCE   420 AA;  47458 MW;  6CA6590D14422324 CRC64;
     MEFPKPRQFR ETSLLMYYLD VVFPLQYISP NNNCLGKREW LLTILTSARP TYYATLCLAL
     LYKESLSTSC RSEQTLVWKR EKTYYYILAL QESQKLLGGL NKTFGITRLK GTVVALACML
     QLIGFESSHL SRGDWRVHLL AANTLIPVLA EGWSTALQSG PPATSIWCEL DESDFDSIDD
     QTSLSFEYLG ALRFLSNSLA KIGILSCISV GPAAPFEDYG HLLDQPGLIQ LEEVLGCKNW
     AMLTILEVGK LDRWKRQEQE HNRLSLKTLA MRAMIIEDML TDELQKLPTS ETLPDLITHI
     YAASIATYLH TVVSGLNPNL SEVQDSVCAT ILLLERLPDL QAVASVTWPL AVTGCMASES
     HKDFFRSTLR SYEATFSSLK KYDGVLEVLE DAWKKREVDT ESPMRWEDLM DHHGLPVLLF