TRI23_CAEEL
ID TRI23_CAEEL Reviewed; 539 AA.
AC Q09654;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=E3 ubiquitin-protein ligase arc-1;
DE EC=2.3.2.27;
DE AltName: Full=Putative GTP-binding protein trim-23 homolog;
DE AltName: Full=RING-type E3 ubiquitin transferase arc-1 {ECO:0000305};
GN Name=arc-1; Synonyms=arl-4; ORFNames=ZK1320.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Acts as an E3 ubiquitin-protein ligase.
CC {ECO:0000250|UniProtKB:P36406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SIMILARITY: In the C-terminal section; belongs to the small GTPase
CC superfamily. Arf family. {ECO:0000305}.
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DR EMBL; Z46934; CAA87044.3; -; Genomic_DNA.
DR PIR; T27752; T27752.
DR RefSeq; NP_496089.3; NM_063688.5.
DR AlphaFoldDB; Q09654; -.
DR SMR; Q09654; -.
DR BioGRID; 39848; 1.
DR IntAct; Q09654; 1.
DR MINT; Q09654; -.
DR STRING; 6239.ZK1320.6; -.
DR EPD; Q09654; -.
DR PaxDb; Q09654; -.
DR EnsemblMetazoa; ZK1320.6.1; ZK1320.6.1; WBGene00000180.
DR GeneID; 174525; -.
DR KEGG; cel:CELE_ZK1320.6; -.
DR UCSC; ZK1320.6; c. elegans.
DR CTD; 174525; -.
DR WormBase; ZK1320.6; CE37598; WBGene00000180; arc-1.
DR eggNOG; KOG0070; Eukaryota.
DR eggNOG; KOG4185; Eukaryota.
DR GeneTree; ENSGT00940000158562; -.
DR HOGENOM; CLU_033905_0_0_1; -.
DR InParanoid; Q09654; -.
DR OMA; ACEERYE; -.
DR OrthoDB; 1362554at2759; -.
DR PhylomeDB; Q09654; -.
DR Reactome; R-CEL-1660514; Synthesis of PIPs at the Golgi membrane.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q09654; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000180; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR InterPro; IPR027370; Znf-RING_LisH.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00184; RING; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW GTP-binding; Metal-binding; Nucleotide-binding; Reference proteome;
KW Transferase; Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..539
FT /note="E3 ubiquitin-protein ligase arc-1"
FT /id="PRO_0000207486"
FT ZN_FING 6..53
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 103..149
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 369..539
FT /note="ARF-like"
FT BINDING 376..383
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 422..426
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 481..484
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 539 AA; 60682 MW; 79F959556BB0755A CRC64;
MNEYGCNVCN EEYSARDPLK CPRVLTGCGH TICHNCAISI AGRNSSIFCP FDRTATQIPG
GDLQNLKKNF ALLELLEKIA DGGGLLEKSG EVVKFDRYSK ERLLNLECDE DSEHVAVIYC
TVCDSNLCER CSESTHSTNV LSKHRRIPLT EKPPPLVHCR LHSSYVVEFV CKELSCDTES
PLMCMMCRDY GRHKGHSHVL IEKEVEDLRE KVREHLGELS KQSETIGNAL HSIDSVIHEL
TPGQEDGSLE ETRQEVRNHF RRLRTALDRD EEDAVETVDR YARNRVESLQ TQKERLEAIS
SKIGNTCTTL QKALIMERGK ILDRKDDLLA LAESTAAEPT AVLDQSQLST RIAFSFLNDR
KLHIGDFIES RVVLLGLDGA GKTSIVRRLK KVQMDTVMAP HPTIGFNIET IHYKNYRLNF
WDVGGLPKLR HLWKHYYSNA QAIFYVIDGY AVERFSEAIK ELNRVMSDPL VGTCPVIVAV
NRKDGYALNG HMDALLSQLE ALPFQHHFHC CDAATGSGID QIIDQITVCL SRLNGTCPV
