ID   BUK1_CLOAB              Reviewed;         355 AA.
AC   Q45829; Q97EN4;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Butyrate kinase 1;
DE            Short=BK 1;
DE            Short=BKI;
DE            EC=2.7.2.7;
GN   Name=buk1; Synonyms=buk; OrderedLocusNames=CA_C3075;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=8244020; DOI=10.1016/0378-1119(93)90182-3;
RA   Walter K.A., Nair R.V., Cary J.W., Bennett G.N., Papoutsakis E.T.;
RT   "Sequence and arrangement of two genes of the butyrate-synthesis pathway of
RT   Clostridium acetobutylicum ATCC 824.";
RL   Gene 134:107-111(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: Catalyzes the conversion of butyryl-CoA through butyryl
CC       phosphate to butyrate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + butanoate = ADP + butanoyl phosphate;
CC         Xref=Rhea:RHEA:13585, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58079, ChEBI:CHEBI:456216; EC=2.7.2.7;
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the acetokinase family. {ECO:0000305}.
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DR   EMBL; L14744; AAA75487.1; -; Genomic_DNA.
DR   EMBL; AE001437; AAK81015.1; -; Genomic_DNA.
DR   PIR; D97278; D97278.
DR   PIR; I40819; I40819.
DR   RefSeq; NP_349675.1; NC_003030.1.
DR   RefSeq; WP_010966356.1; NC_003030.1.
DR   AlphaFoldDB; Q45829; -.
DR   SMR; Q45829; -.
DR   STRING; 272562.CA_C3075; -.
DR   EnsemblBacteria; AAK81015; AAK81015; CA_C3075.
DR   GeneID; 44999562; -.
DR   KEGG; cac:CA_C3075; -.
DR   PATRIC; fig|272562.8.peg.3258; -.
DR   eggNOG; COG3426; Bacteria.
DR   HOGENOM; CLU_048716_0_0_9; -.
DR   OMA; IWHALNQ; -.
DR   OrthoDB; 537106at2; -.
DR   BioCyc; MetaCyc:BUKCLOS-MON; -.
DR   BRENDA; 2.7.2.7; 1452.
DR   UniPathway; UPA00863; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0047761; F:butyrate kinase activity; IDA:MENGO.
DR   GO; GO:0019605; P:butyrate metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00542; Butyrate_kinase; 1.
DR   InterPro; IPR000890; Aliphatic_acid_kin_short-chain.
DR   InterPro; IPR023865; Aliphatic_acid_kinase_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR011245; Butyrate_kin.
DR   PANTHER; PTHR21060; PTHR21060; 1.
DR   PANTHER; PTHR21060:SF3; PTHR21060:SF3; 1.
DR   Pfam; PF00871; Acetate_kinase; 1.
DR   PIRSF; PIRSF036458; Butyrate_kin; 1.
DR   PRINTS; PR00471; ACETATEKNASE.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02707; butyr_kinase; 1.
DR   PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR   PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..355
FT                   /note="Butyrate kinase 1"
FT                   /id="PRO_0000107657"
FT   CONFLICT        338
FT                   /note="A -> R (in Ref. 1; AAA75487)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   355 AA;  38942 MW;  C229E9ED7F1B927C CRC64;
     MYRLLIINPG STSTKIGIYD DEKEIFEKTL RHSAEEIEKY NTIFDQFQFR KNVILDALKE
     ANIEVSSLNA VVGRGGLLKP IVSGTYAVNQ KMLEDLKVGV QGQHASNLGG IIANEIAKEI
     NVPAYIVDPV VVDELDEVSR ISGMADIPRK SIFHALNQKA VARRYAKEVG KKYEDLNLIV
     VHMGGGTSVG THKDGRVIEV NNTLDGEGPF SPERSGGVPI GDLVRLCFSN KYTYEEVMKK
     INGKGGVVSY LNTIDFKAVV DKALEGDKKC ALIYEAFTFQ VAKEIGKCST VLKGNVDAII
     LTGGIAYNEH VCNAIEDRVK FIAPVVRYGG EDELLALAEG GLRVLRGEEK AKEYK