TRI42_HUMAN
ID TRI42_HUMAN Reviewed; 723 AA.
AC Q8IWZ5; A1L4B4; A1L4B6; Q8N832; Q8NDL3;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Tripartite motif-containing protein 42;
GN Name=TRIM42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ARG-244.
RA Meroni G.;
RT "Novel tripartite motif family members.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-244.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-244.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-244.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS
RP ARG-244; MET-475 AND GLU-579.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- INTERACTION:
CC Q8IWZ5; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-5235829, EBI-10173507;
CC Q8IWZ5; P29972: AQP1; NbExp=3; IntAct=EBI-5235829, EBI-745213;
CC Q8IWZ5; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-5235829, EBI-742909;
CC Q8IWZ5; Q96B67: ARRDC3; NbExp=3; IntAct=EBI-5235829, EBI-2875665;
CC Q8IWZ5; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-5235829, EBI-12006308;
CC Q8IWZ5; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-5235829, EBI-16429430;
CC Q8IWZ5; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-5235829, EBI-1642333;
CC Q8IWZ5; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-5235829, EBI-745073;
CC Q8IWZ5; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-5235829, EBI-8643161;
CC Q8IWZ5; Q9H257: CARD9; NbExp=3; IntAct=EBI-5235829, EBI-751319;
CC Q8IWZ5; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-5235829, EBI-744545;
CC Q8IWZ5; Q8NA61: CBY2; NbExp=3; IntAct=EBI-5235829, EBI-741724;
CC Q8IWZ5; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-5235829, EBI-744556;
CC Q8IWZ5; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-5235829, EBI-1104933;
CC Q8IWZ5; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-5235829, EBI-5278764;
CC Q8IWZ5; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-5235829, EBI-739624;
CC Q8IWZ5; Q8TCT0: CERK; NbExp=3; IntAct=EBI-5235829, EBI-10274247;
CC Q8IWZ5; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-5235829, EBI-2321769;
CC Q8IWZ5; Q9H2X0: CHRD; NbExp=5; IntAct=EBI-5235829, EBI-947551;
CC Q8IWZ5; Q02930-3: CREB5; NbExp=6; IntAct=EBI-5235829, EBI-10192698;
CC Q8IWZ5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-5235829, EBI-3867333;
CC Q8IWZ5; O95967: EFEMP2; NbExp=5; IntAct=EBI-5235829, EBI-743414;
CC Q8IWZ5; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-5235829, EBI-2349927;
CC Q8IWZ5; P50402: EMD; NbExp=6; IntAct=EBI-5235829, EBI-489887;
CC Q8IWZ5; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-5235829, EBI-11986315;
CC Q8IWZ5; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-5235829, EBI-6658203;
CC Q8IWZ5; P23142-4: FBLN1; NbExp=3; IntAct=EBI-5235829, EBI-11956479;
CC Q8IWZ5; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-5235829, EBI-11977403;
CC Q8IWZ5; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-5235829, EBI-10242151;
CC Q8IWZ5; P08151: GLI1; NbExp=3; IntAct=EBI-5235829, EBI-308084;
CC Q8IWZ5; O76003: GLRX3; NbExp=6; IntAct=EBI-5235829, EBI-374781;
CC Q8IWZ5; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-5235829, EBI-748515;
CC Q8IWZ5; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-5235829, EBI-11975289;
CC Q8IWZ5; Q08379: GOLGA2; NbExp=3; IntAct=EBI-5235829, EBI-618309;
CC Q8IWZ5; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-5235829, EBI-11978177;
CC Q8IWZ5; P49639: HOXA1; NbExp=12; IntAct=EBI-5235829, EBI-740785;
CC Q8IWZ5; P31273: HOXC8; NbExp=3; IntAct=EBI-5235829, EBI-1752118;
CC Q8IWZ5; Q9H2F3: HSD3B7; NbExp=5; IntAct=EBI-5235829, EBI-3918847;
CC Q8IWZ5; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-5235829, EBI-11955401;
CC Q8IWZ5; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-5235829, EBI-8638439;
CC Q8IWZ5; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-5235829, EBI-747204;
CC Q8IWZ5; Q14005-2: IL16; NbExp=3; IntAct=EBI-5235829, EBI-17178971;
CC Q8IWZ5; Q8NA54: IQUB; NbExp=3; IntAct=EBI-5235829, EBI-10220600;
CC Q8IWZ5; Q7L273: KCTD9; NbExp=6; IntAct=EBI-5235829, EBI-4397613;
CC Q8IWZ5; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-5235829, EBI-6426443;
CC Q8IWZ5; Q5T749: KPRP; NbExp=3; IntAct=EBI-5235829, EBI-10981970;
CC Q8IWZ5; A1A4E9: KRT13; NbExp=3; IntAct=EBI-5235829, EBI-10171552;
CC Q8IWZ5; P19012: KRT15; NbExp=3; IntAct=EBI-5235829, EBI-739566;
CC Q8IWZ5; O76011: KRT34; NbExp=3; IntAct=EBI-5235829, EBI-1047093;
CC Q8IWZ5; Q6A162: KRT40; NbExp=3; IntAct=EBI-5235829, EBI-10171697;
CC Q8IWZ5; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-5235829, EBI-10172150;
CC Q8IWZ5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-5235829, EBI-10172290;
CC Q8IWZ5; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-5235829, EBI-10171774;
CC Q8IWZ5; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-5235829, EBI-10172052;
CC Q8IWZ5; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-5235829, EBI-10176379;
CC Q8IWZ5; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-5235829, EBI-14065470;
CC Q8IWZ5; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-5235829, EBI-3957672;
CC Q8IWZ5; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-5235829, EBI-751260;
CC Q8IWZ5; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-5235829, EBI-10172511;
CC Q8IWZ5; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-5235829, EBI-11958132;
CC Q8IWZ5; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-5235829, EBI-11993254;
CC Q8IWZ5; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-5235829, EBI-11993296;
CC Q8IWZ5; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-5235829, EBI-11987425;
CC Q8IWZ5; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-5235829, EBI-1043191;
CC Q8IWZ5; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-5235829, EBI-739909;
CC Q8IWZ5; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-5235829, EBI-11962058;
CC Q8IWZ5; Q5T7P3: LCE1B; NbExp=6; IntAct=EBI-5235829, EBI-10245913;
CC Q8IWZ5; Q5T751: LCE1C; NbExp=3; IntAct=EBI-5235829, EBI-12224199;
CC Q8IWZ5; Q5T752: LCE1D; NbExp=3; IntAct=EBI-5235829, EBI-11741311;
CC Q8IWZ5; Q5T753: LCE1E; NbExp=3; IntAct=EBI-5235829, EBI-11955335;
CC Q8IWZ5; Q5T754: LCE1F; NbExp=6; IntAct=EBI-5235829, EBI-11958008;
CC Q8IWZ5; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-5235829, EBI-10246607;
CC Q8IWZ5; O14633: LCE2B; NbExp=5; IntAct=EBI-5235829, EBI-11478468;
CC Q8IWZ5; Q5TA81: LCE2C; NbExp=8; IntAct=EBI-5235829, EBI-11973993;
CC Q8IWZ5; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-5235829, EBI-10246750;
CC Q8IWZ5; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-5235829, EBI-9394625;
CC Q8IWZ5; Q5T5A8: LCE3C; NbExp=5; IntAct=EBI-5235829, EBI-10245291;
CC Q8IWZ5; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-5235829, EBI-6658837;
CC Q8IWZ5; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-5235829, EBI-10245456;
CC Q8IWZ5; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-5235829, EBI-10246358;
CC Q8IWZ5; Q5TCM9: LCE5A; NbExp=5; IntAct=EBI-5235829, EBI-11955689;
CC Q8IWZ5; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-5235829, EBI-739832;
CC Q8IWZ5; Q17RB8: LONRF1; NbExp=8; IntAct=EBI-5235829, EBI-2341787;
CC Q8IWZ5; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-5235829, EBI-741037;
CC Q8IWZ5; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-5235829, EBI-746778;
CC Q8IWZ5; O60336: MAPKBP1; NbExp=3; IntAct=EBI-5235829, EBI-947402;
CC Q8IWZ5; O14770-4: MEIS2; NbExp=3; IntAct=EBI-5235829, EBI-8025850;
CC Q8IWZ5; P50222: MEOX2; NbExp=3; IntAct=EBI-5235829, EBI-748397;
CC Q8IWZ5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-5235829, EBI-16439278;
CC Q8IWZ5; P55081: MFAP1; NbExp=3; IntAct=EBI-5235829, EBI-1048159;
CC Q8IWZ5; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-5235829, EBI-10172526;
CC Q8IWZ5; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-5235829, EBI-742948;
CC Q8IWZ5; Q86SG6: NEK8; NbExp=3; IntAct=EBI-5235829, EBI-1752987;
CC Q8IWZ5; Q7Z3S9: NOTCH2NLA; NbExp=6; IntAct=EBI-5235829, EBI-945833;
CC Q8IWZ5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-5235829, EBI-22310682;
CC Q8IWZ5; P32242: OTX1; NbExp=3; IntAct=EBI-5235829, EBI-740446;
CC Q8IWZ5; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-5235829, EBI-11956269;
CC Q8IWZ5; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-5235829, EBI-14084211;
CC Q8IWZ5; O15162: PLSCR1; NbExp=3; IntAct=EBI-5235829, EBI-740019;
CC Q8IWZ5; Q9NRQ2: PLSCR4; NbExp=5; IntAct=EBI-5235829, EBI-769257;
CC Q8IWZ5; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-5235829, EBI-302345;
CC Q8IWZ5; Q12837: POU4F2; NbExp=5; IntAct=EBI-5235829, EBI-17236143;
CC Q8IWZ5; O43741: PRKAB2; NbExp=3; IntAct=EBI-5235829, EBI-1053424;
CC Q8IWZ5; O75360: PROP1; NbExp=3; IntAct=EBI-5235829, EBI-9027467;
CC Q8IWZ5; P25786: PSMA1; NbExp=3; IntAct=EBI-5235829, EBI-359352;
CC Q8IWZ5; O00233: PSMD9; NbExp=3; IntAct=EBI-5235829, EBI-750973;
CC Q8IWZ5; P43115-12: PTGER3; NbExp=3; IntAct=EBI-5235829, EBI-10234038;
CC Q8IWZ5; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-5235829, EBI-948428;
CC Q8IWZ5; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-5235829, EBI-744023;
CC Q8IWZ5; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-5235829, EBI-743428;
CC Q8IWZ5; Q06455-4: RUNX1T1; NbExp=3; IntAct=EBI-5235829, EBI-10224192;
CC Q8IWZ5; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-5235829, EBI-748391;
CC Q8IWZ5; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-5235829, EBI-11955083;
CC Q8IWZ5; O75093: SLIT1; NbExp=3; IntAct=EBI-5235829, EBI-947791;
CC Q8IWZ5; Q92922: SMARCC1; NbExp=3; IntAct=EBI-5235829, EBI-355653;
CC Q8IWZ5; P49901: SMCP; NbExp=3; IntAct=EBI-5235829, EBI-750494;
CC Q8IWZ5; Q99932-2: SPAG8; NbExp=5; IntAct=EBI-5235829, EBI-11959123;
CC Q8IWZ5; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-5235829, EBI-5235340;
CC Q8IWZ5; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-5235829, EBI-2212028;
CC Q8IWZ5; O75716: STK16; NbExp=6; IntAct=EBI-5235829, EBI-749295;
CC Q8IWZ5; Q5VWN6-2: TASOR2; NbExp=3; IntAct=EBI-5235829, EBI-10172380;
CC Q8IWZ5; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-5235829, EBI-11974855;
CC Q8IWZ5; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-5235829, EBI-11952651;
CC Q8IWZ5; O43711: TLX3; NbExp=3; IntAct=EBI-5235829, EBI-3939165;
CC Q8IWZ5; Q86TG1: TMEM150A; NbExp=3; IntAct=EBI-5235829, EBI-2799342;
CC Q8IWZ5; Q13077: TRAF1; NbExp=3; IntAct=EBI-5235829, EBI-359224;
CC Q8IWZ5; Q12933: TRAF2; NbExp=3; IntAct=EBI-5235829, EBI-355744;
CC Q8IWZ5; P0DI81: TRAPPC2; NbExp=3; IntAct=EBI-5235829, EBI-5663373;
CC Q8IWZ5; P36406: TRIM23; NbExp=3; IntAct=EBI-5235829, EBI-740098;
CC Q8IWZ5; P14373: TRIM27; NbExp=3; IntAct=EBI-5235829, EBI-719493;
CC Q8IWZ5; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-5235829, EBI-2825190;
CC Q8IWZ5; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-5235829, EBI-11957216;
CC Q8IWZ5; Q8NEZ2-2: VPS37A; NbExp=3; IntAct=EBI-5235829, EBI-10270911;
CC Q8IWZ5; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-5235829, EBI-11747707;
CC Q8IWZ5; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-5235829, EBI-743787;
CC Q8IWZ5; P27348: YWHAQ; NbExp=4; IntAct=EBI-5235829, EBI-359854;
CC Q8IWZ5; P25490: YY1; NbExp=3; IntAct=EBI-5235829, EBI-765538;
CC Q8IWZ5; Q9Y2K1: ZBTB1; NbExp=3; IntAct=EBI-5235829, EBI-2682961;
CC Q8IWZ5; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-5235829, EBI-373456;
CC Q8IWZ5; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-5235829, EBI-744257;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IWZ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IWZ5-2; Sequence=VSP_012066, VSP_012067;
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05042.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF521868; AAO14945.1; -; mRNA.
DR EMBL; AK097416; BAC05042.1; ALT_SEQ; mRNA.
DR EMBL; AC026324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79015.1; -; Genomic_DNA.
DR EMBL; BC130472; AAI30473.1; -; mRNA.
DR EMBL; BC130474; AAI30475.1; -; mRNA.
DR EMBL; AL833848; CAD38707.1; -; mRNA.
DR CCDS; CCDS3113.1; -. [Q8IWZ5-1]
DR RefSeq; NP_689829.3; NM_152616.4. [Q8IWZ5-1]
DR AlphaFoldDB; Q8IWZ5; -.
DR SMR; Q8IWZ5; -.
DR BioGRID; 130425; 148.
DR IntAct; Q8IWZ5; 143.
DR STRING; 9606.ENSP00000286349; -.
DR iPTMnet; Q8IWZ5; -.
DR PhosphoSitePlus; Q8IWZ5; -.
DR BioMuta; TRIM42; -.
DR DMDM; 296452851; -.
DR MassIVE; Q8IWZ5; -.
DR PaxDb; Q8IWZ5; -.
DR PeptideAtlas; Q8IWZ5; -.
DR PRIDE; Q8IWZ5; -.
DR ProteomicsDB; 70941; -. [Q8IWZ5-1]
DR ProteomicsDB; 70942; -. [Q8IWZ5-2]
DR Antibodypedia; 1220; 87 antibodies from 16 providers.
DR DNASU; 287015; -.
DR Ensembl; ENST00000286349.4; ENSP00000286349.3; ENSG00000155890.4. [Q8IWZ5-1]
DR GeneID; 287015; -.
DR KEGG; hsa:287015; -.
DR MANE-Select; ENST00000286349.4; ENSP00000286349.3; NM_152616.5; NP_689829.3.
DR UCSC; uc003eto.3; human. [Q8IWZ5-1]
DR CTD; 287015; -.
DR DisGeNET; 287015; -.
DR GeneCards; TRIM42; -.
DR HGNC; HGNC:19014; TRIM42.
DR HPA; ENSG00000155890; Tissue enriched (testis).
DR neXtProt; NX_Q8IWZ5; -.
DR OpenTargets; ENSG00000155890; -.
DR PharmGKB; PA134894780; -.
DR VEuPathDB; HostDB:ENSG00000155890; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00530000064220; -.
DR HOGENOM; CLU_023245_0_0_1; -.
DR InParanoid; Q8IWZ5; -.
DR OMA; CDRSHCM; -.
DR OrthoDB; 207616at2759; -.
DR PhylomeDB; Q8IWZ5; -.
DR TreeFam; TF336556; -.
DR PathwayCommons; Q8IWZ5; -.
DR SignaLink; Q8IWZ5; -.
DR BioGRID-ORCS; 287015; 10 hits in 1105 CRISPR screens.
DR GenomeRNAi; 287015; -.
DR Pharos; Q8IWZ5; Tdark.
DR PRO; PR:Q8IWZ5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8IWZ5; protein.
DR Bgee; ENSG00000155890; Expressed in left testis and 15 other tissues.
DR Genevisible; Q8IWZ5; HS.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd16578; RING-HC_TRIM42_C-III; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042765; TRIM42_RING-HC.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..723
FT /note="Tripartite motif-containing protein 42"
FT /id="PRO_0000056263"
FT DOMAIN 434..492
FT /note="COS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00586"
FT DOMAIN 603..701
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT ZN_FING 146..192
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 235..280
FT /note="B box-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT ZN_FING 285..326
FT /note="B box-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 382..407
FT /evidence="ECO:0000255"
FT BINDING 290
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 293
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 313
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 318
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT VAR_SEQ 347..369
FT /note="VRYEIDNDLMEFNILKNSFKADK -> GPPLFHSFSLTSSSGTHGEDGVG
FT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_012066"
FT VAR_SEQ 370..723
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_012067"
FT VARIANT 244
FT /note="K -> R (in dbSNP:rs698673)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.1, ECO:0000269|Ref.4"
FT /id="VAR_052143"
FT VARIANT 475
FT /note="V -> M (in dbSNP:rs28594654)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_034468"
FT VARIANT 579
FT /note="A -> E (in dbSNP:rs9876490)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_034469"
FT CONFLICT 516
FT /note="I -> T (in Ref. 2; BAC05042)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 723 AA; 82745 MW; 40897D5AF9B186A9 CRC64;
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC QFCHCTCSES
PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI ITFHKGRLRS IHTSSKTALR
TGSSDTQVDE VKSIPANSHL VNHLNCPMCS RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT
ENFFILICPV CDRSHCMPYS NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV
CRNKRIAYKR CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE IDNDLMEFNI
LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN LEVSRQKEIE KYVYVTTMKV
NEMDGLIAYS KEALKETGQV AFLQSAKILV DQIEDGIQTT YRPDPQLRLH SINYVPLDFV
ELSSAIHELF PTGPKKVRSS GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML
SFSNTDKKAK VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM ELCGQIRDIM
QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD GHGKNRAKWG LLKNIQSALQ
KHF
