TRI42_MOUSE
ID TRI42_MOUSE Reviewed; 723 AA.
AC Q9D2H5; E9QN55;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Tripartite motif-containing protein 42;
GN Name=Trim42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AK019654; BAB31824.1; -; mRNA.
DR EMBL; AC126931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS23422.1; -.
DR RefSeq; NP_084495.2; NM_030219.2.
DR AlphaFoldDB; Q9D2H5; -.
DR BioGRID; 219699; 4.
DR STRING; 10090.ENSMUSP00000035026; -.
DR iPTMnet; Q9D2H5; -.
DR PhosphoSitePlus; Q9D2H5; -.
DR PaxDb; Q9D2H5; -.
DR PRIDE; Q9D2H5; -.
DR ProteomicsDB; 258977; -.
DR Antibodypedia; 1220; 87 antibodies from 16 providers.
DR DNASU; 78911; -.
DR Ensembl; ENSMUST00000035026; ENSMUSP00000035026; ENSMUSG00000032451.
DR GeneID; 78911; -.
DR KEGG; mmu:78911; -.
DR UCSC; uc009rdc.1; mouse.
DR CTD; 287015; -.
DR MGI; MGI:1926161; Trim42.
DR VEuPathDB; HostDB:ENSMUSG00000032451; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00530000064220; -.
DR HOGENOM; CLU_023245_0_0_1; -.
DR InParanoid; Q9D2H5; -.
DR OMA; CDRSHCM; -.
DR OrthoDB; 207616at2759; -.
DR PhylomeDB; Q9D2H5; -.
DR TreeFam; TF336556; -.
DR BioGRID-ORCS; 78911; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q9D2H5; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D2H5; protein.
DR Bgee; ENSMUSG00000032451; Expressed in seminiferous tubule of testis and 13 other tissues.
DR Genevisible; Q9D2H5; MM.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR CDD; cd16578; RING-HC_TRIM42_C-III; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042765; TRIM42_RING-HC.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..723
FT /note="Tripartite motif-containing protein 42"
FT /id="PRO_0000056264"
FT DOMAIN 434..492
FT /note="COS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00586"
FT DOMAIN 603..701
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT ZN_FING 146..192
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 235..280
FT /note="B box-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT ZN_FING 285..326
FT /note="B box-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 382..412
FT /evidence="ECO:0000255"
FT BINDING 290
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 293
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 313
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 318
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT CONFLICT 679
FT /note="V -> I (in Ref. 1; BAB31824)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 723 AA; 82953 MW; 0F6BCD01888E70B1 CRC64;
METAMCVCSP CCTWQRCCPR LFSCLCCKFI FTSERNCTCF PCPYKDERNC QFCHCTCAEN
PNCHWCCCSW ANDPNCKCCC TASTNLKCYY YESHCCRNVT ITFRKGRLRS IVTSSKTALR
VGSSDTQMDE PKTMPASSHL VSHLTCPMCN RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT
ENFFILICPM CSRSHCMPYS HQMHLPENYL RGRLTKRYMQ QHGYLKWRFD RSSGPILCQV
CRTRRIAYKR CVTCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEDQDEKIC IHHPSSRINE
YCRSDNQLLC AFCKIAFHNG HDTVSLIDAC SERSAALFSA IAKFKAVRYE IDNDLMEFNI
LKSSFKADKE AKRKEVRNGF LKLRAILQEK EKIIMEQIEN LEVSRQKEIE KYVYITTMKV
NEMDGLIAYS KEALKETGQV AFLQSAKILV DQIEEGIQNT FRPDPQLRLH SLHCIPLDFA
ELSNAIHELF PTGPKKACSS GDSLPSQYPI HSEMMIARKV TFSTHSFGNQ QIYQRSSSLI
SFNTANDKGK MGLENYGRAQ SAAPAKTTDG LYTYWSATGE TQPPQSSNSF HNWYSFNDTS
VRTPGPIVIY QTLVYPRAAK VYWTCPTEDV DSFEMEFYEL VTTPPNNVRT ELCGQIRDIL
QQNLELHNLT PNTEYLFKVR AINDNGPGQW SDICKVVTPD GRGKNRAKWG LLKNIQSALQ
KRF
