TRI43_HUMAN
ID TRI43_HUMAN Reviewed; 446 AA.
AC Q96BQ3; Q53TJ7;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Tripartite motif-containing protein 43;
GN Name=TRIM43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96BQ3; Q8TC92: ENOX1; NbExp=6; IntAct=EBI-2129899, EBI-713221;
CC Q96BQ3; Q14451-3: GRB7; NbExp=3; IntAct=EBI-2129899, EBI-11991632;
CC Q96BQ3; P37173: TGFBR2; NbExp=3; IntAct=EBI-2129899, EBI-296151;
CC Q96BQ3; P61086: UBE2K; NbExp=3; IntAct=EBI-2129899, EBI-473850;
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AC009237; AAY14782.1; -; Genomic_DNA.
DR EMBL; BC015353; AAH15353.1; -; mRNA.
DR CCDS; CCDS2015.1; -.
DR RefSeq; NP_620155.1; NM_138800.2.
DR AlphaFoldDB; Q96BQ3; -.
DR SMR; Q96BQ3; -.
DR BioGRID; 126213; 54.
DR IntAct; Q96BQ3; 22.
DR STRING; 9606.ENSP00000272395; -.
DR BioMuta; TRIM43; -.
DR DMDM; 56404939; -.
DR MassIVE; Q96BQ3; -.
DR PaxDb; Q96BQ3; -.
DR PeptideAtlas; Q96BQ3; -.
DR PRIDE; Q96BQ3; -.
DR Antibodypedia; 32350; 134 antibodies from 19 providers.
DR DNASU; 129868; -.
DR Ensembl; ENST00000272395.3; ENSP00000272395.2; ENSG00000144015.5.
DR GeneID; 129868; -.
DR KEGG; hsa:129868; -.
DR MANE-Select; ENST00000272395.3; ENSP00000272395.2; NM_138800.3; NP_620155.1.
DR UCSC; uc002suv.4; human.
DR CTD; 129868; -.
DR DisGeNET; 129868; -.
DR GeneCards; TRIM43; -.
DR HGNC; HGNC:19015; TRIM43.
DR HPA; ENSG00000144015; Not detected.
DR neXtProt; NX_Q96BQ3; -.
DR OpenTargets; ENSG00000144015; -.
DR PharmGKB; PA134936799; -.
DR VEuPathDB; HostDB:ENSG00000144015; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160005; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; Q96BQ3; -.
DR OMA; PLCEERD; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; Q96BQ3; -.
DR TreeFam; TF338674; -.
DR PathwayCommons; Q96BQ3; -.
DR SignaLink; Q96BQ3; -.
DR BioGRID-ORCS; 129868; 24 hits in 1070 CRISPR screens.
DR GenomeRNAi; 129868; -.
DR Pharos; Q96BQ3; Tdark.
DR PRO; PR:Q96BQ3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96BQ3; protein.
DR Bgee; ENSG00000144015; Expressed in lower esophagus mucosa and 8 other tissues.
DR Genevisible; Q96BQ3; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..446
FT /note="Tripartite motif-containing protein 43"
FT /id="PRO_0000056265"
FT DOMAIN 269..446
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 129..158
FT /evidence="ECO:0000255"
FT COILED 190..220
FT /evidence="ECO:0000255"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 446 AA; 52265 MW; 805E4AA25617724A CRC64;
MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP
KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE
HGAHKHHPIE EAAEEHREKL LKQMRILWKK IQENQRNLYE EGRTAFLWRG NVVLRAQMIR
NEYRKLHPVL HKEEKQHLER LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP
DVELLQDLGD IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI
RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA LGVCNNSWIR
KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL GRVGVFLDFE SGSVSFLNVT
KSSLIWSYPA GSLTFPVRPF FYTGHR
