ID   TRI44_PONAB             Reviewed;         344 AA.
AC   Q5R846;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Tripartite motif-containing protein 44;
GN   Name=TRIM44;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the process of differentiation and
CC       maturation of neuronal cells (By similarity). May regulate the activity
CC       of TRIM17 (By similarity). Is a negative regulator of PAX6 expression
CC       (By similarity). {ECO:0000250|UniProtKB:Q96DX7}.
CC   -!- SUBUNIT: Interacts (via coiled coil) with TRIM17 (via coiled coil).
CC       {ECO:0000250|UniProtKB:Q96DX7}.
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DR   EMBL; CR859908; CAH92064.1; -; mRNA.
DR   RefSeq; NP_001126201.1; NM_001132729.2.
DR   AlphaFoldDB; Q5R846; -.
DR   STRING; 9601.ENSPPYP00000003851; -.
DR   Ensembl; ENSPPYT00000056148; ENSPPYP00000034514; ENSPPYG00000003355.
DR   GeneID; 100173169; -.
DR   KEGG; pon:100173169; -.
DR   CTD; 54765; -.
DR   eggNOG; ENOG502RHR7; Eukaryota.
DR   GeneTree; ENSGT00440000034605; -.
DR   HOGENOM; CLU_070347_0_0_1; -.
DR   InParanoid; Q5R846; -.
DR   OMA; LREAYMW; -.
DR   OrthoDB; 869824at2759; -.
DR   TreeFam; TF333911; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR000315; Znf_B-box.
DR   Pfam; PF00643; zf-B_box; 1.
DR   SMART; SM00336; BBOX; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Metal-binding; Phosphoprotein; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..344
FT                   /note="Tripartite motif-containing protein 44"
FT                   /id="PRO_0000324098"
FT   ZN_FING         174..215
FT                   /note="B box-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          290..325
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        75..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..165
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..334
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         179
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         182
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         201
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         207
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   MOD_RES         336
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QXA7"
FT   MOD_RES         339
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QXA7"
SQ   SEQUENCE   344 AA;  38456 MW;  595584AD36F2D691 CRC64;
     MASGVGAAFE ELPHDGTCDE CEPDEAPGAE EVCRECGFCY CRRHAEAHRQ KFLSHHLAEY
     VHGAQAWTPP ADGEGAGKEE AEVKVEQERE IESEAGEESE SEEESESEEE SETEEESEDE
     SDEESEEDSE EEMEDEQESE AEEDNQEEGE SEAEGETEAE SEFDPEIEME AERVAKRKCP
     DHGLDLSTYC QEDRQLICVL CPVIGAHQGH QLSTLDEAFE ELRSKDSGGL KAAMIELVER
     LKFKSSDPKV TRDQMKMFIQ QEFKKVQKVI ADEEQKALHL VDIQEAMATA HVTEILADIQ
     SHMDRLMTQM AQAKEQLDTS NESAEPKAEG DEEGPSGASE EEDT