BUK2_THEMA
ID BUK2_THEMA Reviewed; 375 AA.
AC Q9X278;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable butyrate kinase 2 {ECO:0000255|HAMAP-Rule:MF_00542};
DE Short=BK 2 {ECO:0000255|HAMAP-Rule:MF_00542};
DE EC=2.7.2.7 {ECO:0000255|HAMAP-Rule:MF_00542};
DE AltName: Full=Branched-chain carboxylic acid kinase 2 {ECO:0000255|HAMAP-Rule:MF_00542};
GN Name=buk2 {ECO:0000255|HAMAP-Rule:MF_00542}; OrderedLocusNames=TM_1756;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + butanoate = ADP + butanoyl phosphate;
CC Xref=Rhea:RHEA:13585, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:58079, ChEBI:CHEBI:456216; EC=2.7.2.7;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00542};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00542}.
CC -!- SIMILARITY: Belongs to the acetokinase family. {ECO:0000255|HAMAP-
CC Rule:MF_00542}.
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DR EMBL; AE000512; AAD36821.1; -; Genomic_DNA.
DR PIR; E72214; E72214.
DR RefSeq; NP_229554.1; NC_000853.1.
DR RefSeq; WP_004082291.1; NZ_CP011107.1.
DR PDB; 1SAZ; X-ray; 2.50 A; A=1-375.
DR PDB; 1X9J; X-ray; 3.00 A; A/B/C/D/E/F/G/H=1-375.
DR PDBsum; 1SAZ; -.
DR PDBsum; 1X9J; -.
DR AlphaFoldDB; Q9X278; -.
DR SMR; Q9X278; -.
DR STRING; 243274.THEMA_05455; -.
DR DrugBank; DB03909; Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate.
DR DrugBank; DB01942; Formic acid.
DR EnsemblBacteria; AAD36821; AAD36821; TM_1756.
DR KEGG; tma:TM1756; -.
DR eggNOG; COG3426; Bacteria.
DR InParanoid; Q9X278; -.
DR OMA; IWHALNQ; -.
DR OrthoDB; 537106at2; -.
DR BRENDA; 2.7.2.7; 6331.
DR EvolutionaryTrace; Q9X278; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008776; F:acetate kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0047761; F:butyrate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006083; P:acetate metabolic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00542; Butyrate_kinase; 1.
DR InterPro; IPR000890; Aliphatic_acid_kin_short-chain.
DR InterPro; IPR023865; Aliphatic_acid_kinase_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR011245; Butyrate_kin.
DR PANTHER; PTHR21060; PTHR21060; 1.
DR PANTHER; PTHR21060:SF3; PTHR21060:SF3; 1.
DR Pfam; PF00871; Acetate_kinase; 1.
DR PIRSF; PIRSF036458; Butyrate_kin; 1.
DR PRINTS; PR00471; ACETATEKNASE.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR02707; butyr_kinase; 1.
DR PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..375
FT /note="Probable butyrate kinase 2"
FT /id="PRO_0000107675"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 11..20
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 23..31
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 34..38
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 43..46
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 47..59
FT /evidence="ECO:0007829|PDB:1SAZ"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 65..67
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 69..74
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 83..87
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 90..98
FT /evidence="ECO:0007829|PDB:1SAZ"
FT TURN 99..101
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 107..120
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 124..128
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 137..139
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:1X9J"
FT HELIX 155..168
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 173..175
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 177..193
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 196..200
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 203..205
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 220..227
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 236..238
FT /evidence="ECO:0007829|PDB:1SAZ"
FT TURN 240..243
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 247..251
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 256..264
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 268..291
FT /evidence="ECO:0007829|PDB:1SAZ"
FT TURN 292..294
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 297..303
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 304..307
FT /evidence="ECO:0007829|PDB:1SAZ"
FT TURN 309..311
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 312..320
FT /evidence="ECO:0007829|PDB:1SAZ"
FT TURN 321..323
FT /evidence="ECO:0007829|PDB:1SAZ"
FT STRAND 326..331
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 334..346
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 355..369
FT /evidence="ECO:0007829|PDB:1SAZ"
FT HELIX 371..373
FT /evidence="ECO:0007829|PDB:1SAZ"
SQ SEQUENCE 375 AA; 42022 MW; E42C4887071D008D CRC64;
MFRILTINPG STSTKLSIFE DERMVKMQNF SHSPDELGRF QKILDQLEFR EKIARQFVEE
TGYSLSSFSA FVSRGGLLDP IPGGVYLVDG LMIKTLKSGK NGEHASNLGA IIAHRFSSET
GVPAYVVDPV VVDEMEDVAR VSGHPNYQRK SIFHALNQKT VAKEVARMMN KRYEEMNLVV
AHMGGGISIA AHRKGRVIDV NNALDGDGPF TPERSGTLPL TQLVDLCFSG KFTYEEMKKR
IVGNGGLVAY LGTSDAREVV RRIKQGDEWA KRVYRAMAYQ IAKWIGKMAA VLKGEVDFIV
LTGGLAHEKE FLVPWITKRV SFIAPVLVFP GSNEEKALAL SALRVLRGEE KPKNYSEESR
RWRERYDSYL DGILR
