TRI49_HUMAN
ID TRI49_HUMAN Reviewed; 452 AA.
AC P0CI25; A0AVR7; A0AVR9; Q6DJV1; Q9NS80;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Tripartite motif-containing protein 49;
DE AltName: Full=RING finger protein 18;
DE AltName: Full=Testis-specific RING-finger protein;
GN Name=TRIM49; Synonyms=RNF18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=11018261; DOI=10.1016/s0167-4781(00)00193-7;
RA Yoshikawa T., Seki N., Azuma T., Masuho Y., Muramatsu M., Miyajima N.,
RA Saito T.;
RT "Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by
RT the virtual transcribed sequence (VTS) approach.";
RL Biochim. Biophys. Acta 1493:349-355(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P0CI25; P61024: CKS1B; NbExp=4; IntAct=EBI-6427421, EBI-456371;
CC P0CI25; P42858: HTT; NbExp=9; IntAct=EBI-6427421, EBI-466029;
CC P0CI25; Q9H8M7: MINDY3; NbExp=6; IntAct=EBI-6427421, EBI-724928;
CC P0CI25; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-6427421, EBI-11956563;
CC -!- TISSUE SPECIFICITY: Preferentially expressed in testis.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AB037682; BAB03503.1; -; mRNA.
DR EMBL; AP004607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC075019; AAH75019.1; -; mRNA.
DR EMBL; BC075020; AAH75020.1; -; mRNA.
DR EMBL; BC126472; AAI26473.1; -; mRNA.
DR CCDS; CCDS8287.1; -.
DR RefSeq; NP_065091.1; NM_020358.2.
DR AlphaFoldDB; P0CI25; -.
DR SMR; P0CI25; -.
DR BioGRID; 121361; 35.
DR IntAct; P0CI25; 6.
DR STRING; 9606.ENSP00000327604; -.
DR iPTMnet; P0CI25; -.
DR PhosphoSitePlus; P0CI25; -.
DR BioMuta; TRIM49; -.
DR DMDM; 310947307; -.
DR MassIVE; P0CI25; -.
DR PaxDb; P0CI25; -.
DR PeptideAtlas; P0CI25; -.
DR PRIDE; P0CI25; -.
DR Antibodypedia; 31517; 159 antibodies from 18 providers.
DR DNASU; 57093; -.
DR Ensembl; ENST00000329758.5; ENSP00000327604.1; ENSG00000168930.13.
DR GeneID; 57093; -.
DR KEGG; hsa:57093; -.
DR MANE-Select; ENST00000329758.5; ENSP00000327604.1; NM_020358.2; NP_065091.1.
DR UCSC; uc001pdb.3; human.
DR CTD; 57093; -.
DR GeneCards; TRIM49; -.
DR HGNC; HGNC:13431; TRIM49.
DR HPA; ENSG00000168930; Not detected.
DR MIM; 606124; gene.
DR neXtProt; NX_P0CI25; -.
DR OpenTargets; ENSG00000168930; -.
DR VEuPathDB; HostDB:ENSG00000168930; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000165665; -.
DR InParanoid; P0CI25; -.
DR OMA; CVGCNHQ; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; P0CI25; -.
DR TreeFam; TF338674; -.
DR PathwayCommons; P0CI25; -.
DR SignaLink; P0CI25; -.
DR BioGRID-ORCS; 57093; 85 hits in 637 CRISPR screens.
DR GenomeRNAi; 57093; -.
DR Pharos; P0CI25; Tdark.
DR PRO; PR:P0CI25; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P0CI25; protein.
DR Bgee; ENSG00000168930; Expressed in testis and 6 other tissues.
DR ExpressionAtlas; P0CI25; baseline and differential.
DR Genevisible; P0CI25; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..452
FT /note="Tripartite motif-containing protein 49"
FT /id="PRO_0000056273"
FT DOMAIN 269..452
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT VARIANT 373
FT /note="G -> R (in dbSNP:rs12417980)"
FT /id="VAR_061824"
FT CONFLICT 298
FT /note="N -> S (in Ref. 3; AAH75019/AAH75020)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 452 AA; 52888 MW; 5FB6528E7B5BB4BB CRC64;
MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV QCSECTKSTE
QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSQE
HRYHRHRPIE WAAEEHREKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR
AEYQKMPAFH HEEEKHNLEM LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP
DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANNDI
FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS WNWAFGVCNM
YRKEKNQNEK IDGKAGLFLL GCVKNDIQCS LFTTSPLMLQ YIPKPTSRVG LFLDCEAKTV
SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF
