TRI51_HUMAN
ID TRI51_HUMAN Reviewed; 452 AA.
AC Q9BSJ1; A6NMG2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Tripartite motif-containing protein 51;
DE AltName: Full=SPRY domain-containing protein 5;
GN Name=TRIM51; Synonyms=SPRYD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 83-259 (ISOFORM 1).
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BSJ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BSJ1-2; Sequence=VSP_039765;
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH05014.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC036111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW73688.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73689.1; -; Genomic_DNA.
DR EMBL; BC005014; AAH05014.1; ALT_INIT; mRNA.
DR EMBL; DV080294; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_116070.2; NM_032681.3. [Q9BSJ1-1]
DR AlphaFoldDB; Q9BSJ1; -.
DR SMR; Q9BSJ1; -.
DR BioGRID; 124248; 4.
DR IntAct; Q9BSJ1; 3.
DR STRING; 9606.ENSP00000395086; -.
DR iPTMnet; Q9BSJ1; -.
DR PhosphoSitePlus; Q9BSJ1; -.
DR BioMuta; TRIM51; -.
DR DMDM; 306526243; -.
DR jPOST; Q9BSJ1; -.
DR MassIVE; Q9BSJ1; -.
DR PaxDb; Q9BSJ1; -.
DR PeptideAtlas; Q9BSJ1; -.
DR PRIDE; Q9BSJ1; -.
DR Antibodypedia; 27162; 135 antibodies from 24 providers.
DR DNASU; 84767; -.
DR Ensembl; ENST00000244891.3; ENSP00000244891.3; ENSG00000124900.12. [Q9BSJ1-2]
DR Ensembl; ENST00000449290.6; ENSP00000395086.2; ENSG00000124900.12. [Q9BSJ1-1]
DR GeneID; 84767; -.
DR KEGG; hsa:84767; -.
DR MANE-Select; ENST00000449290.6; ENSP00000395086.2; NM_032681.4; NP_116070.2.
DR UCSC; uc010rip.3; human. [Q9BSJ1-1]
DR CTD; 84767; -.
DR GeneCards; TRIM51; -.
DR HGNC; HGNC:19023; TRIM51.
DR HPA; ENSG00000124900; Not detected.
DR neXtProt; NX_Q9BSJ1; -.
DR OpenTargets; ENSG00000124900; -.
DR PharmGKB; PA134949173; -.
DR VEuPathDB; HostDB:ENSG00000124900; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163419; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; Q9BSJ1; -.
DR OMA; RRNSHIF; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; Q9BSJ1; -.
DR TreeFam; TF338674; -.
DR PathwayCommons; Q9BSJ1; -.
DR SignaLink; Q9BSJ1; -.
DR BioGRID-ORCS; 84767; 1 hit in 204 CRISPR screens.
DR GenomeRNAi; 84767; -.
DR Pharos; Q9BSJ1; Tdark.
DR PRO; PR:Q9BSJ1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9BSJ1; protein.
DR Bgee; ENSG00000124900; Expressed in prefrontal cortex and 2 other tissues.
DR Genevisible; Q9BSJ1; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..452
FT /note="Tripartite motif-containing protein 51"
FT /id="PRO_0000328724"
FT DOMAIN 269..452
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT VAR_SEQ 1..143
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039765"
SQ SEQUENCE 452 AA; 52285 MW; 41C3D56D372A40AB CRC64;
MNSGILQVFQ RALTCPICMN YFLDPVTIDC GHSFCRPCLY LNWQDTAVLA QCSECKKTTR
QRNLNTDICL KNMAFIARKA SLRQFLSSEE QICGMHRETK KMFCEVDKSL LCLPCSNSQE
HRNHIHCPIE WAAEERREEL LKKMQSLWEK ACENLRNLNM ETTRTRCWKD YVSLRIEAIR
AEYQKMPAFL HEEEQHHLER LRKEGEDIFQ QLNESKARME HSRELLRGMY EDLKQMCHKA
DVELLQAFGD ILHRYESLLL QVSEPVNPEL SAGPITGLLD SLSGFRVDFT LQPERANSHI
FLCGDLRSMN VGCDPQDDPD ITGKSECFLV WGAQAFTSGK YYWEVHMGDS WNWAFGVCNN
YWKEKRQNDK IDGEEGLFLL GCVKEDTHCS LFTTSPLVVQ YVPRPTSTVG LFLDCEGRTV
SFVDVDQSSL IYTIPNCSFS PPLRPIFCCS HF
