TRI54_HUMAN
ID TRI54_HUMAN Reviewed; 358 AA.
AC Q9BYV2; A5D8T7; Q53SY4; Q9BYV3;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Tripartite motif-containing protein 54;
DE AltName: Full=Muscle-specific RING finger protein;
DE Short=MuRF;
DE AltName: Full=Muscle-specific RING finger protein 3;
DE Short=MuRF-3;
DE Short=MuRF3;
DE AltName: Full=RING finger protein 30;
GN Name=TRIM54; Synonyms=MURF, MURF3, RNF30;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY,
RP OLIGOMERIZATION, AND INTERACTION WITH TRIM63 AND TRIM55.
RX PubMed=11243782; DOI=10.1006/jmbi.2001.4448;
RA Centner T., Yano J., Kimura E., McElhinny A.S., Pelin K., Witt C.C.,
RA Bang M.-L., Trombitas K., Granzier H., Gregorio C.C., Sorimachi H.,
RA Labeit S.;
RT "Identification of muscle specific ring finger proteins as potential
RT regulators of the titin kinase domain.";
RL J. Mol. Biol. 306:717-726(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 122-168 IN COMPLEX WITH ZINC
RP IONS.
RG Structural genomics consortium (SGC);
RT "The B-box domain of TRIM54.";
RL Submitted (FEB-2011) to the PDB data bank.
CC -!- FUNCTION: May bind and stabilize microtubules during myotubes
CC formation. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer and heterooligomer. Interacts with tubulin (By
CC similarity). Interacts with TRIM63 and probably with TRIM55.
CC {ECO:0000250, ECO:0000269|PubMed:11243782, ECO:0000269|Ref.5}.
CC -!- INTERACTION:
CC Q9BYV2; Q8NFM4: ADCY4; NbExp=3; IntAct=EBI-2130429, EBI-2838710;
CC Q9BYV2; Q9BRQ8: AIFM2; NbExp=3; IntAct=EBI-2130429, EBI-3956936;
CC Q9BYV2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-2130429, EBI-17183751;
CC Q9BYV2; P53365: ARFIP2; NbExp=3; IntAct=EBI-2130429, EBI-638194;
CC Q9BYV2; Q12774: ARHGEF5; NbExp=6; IntAct=EBI-2130429, EBI-602199;
CC Q9BYV2; Q15052: ARHGEF6; NbExp=3; IntAct=EBI-2130429, EBI-1642523;
CC Q9BYV2; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-2130429, EBI-742909;
CC Q9BYV2; Q13895: BYSL; NbExp=7; IntAct=EBI-2130429, EBI-358049;
CC Q9BYV2; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-2130429, EBI-8643161;
CC Q9BYV2; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-2130429, EBI-747505;
CC Q9BYV2; Q9BXJ5: C1QTNF2; NbExp=3; IntAct=EBI-2130429, EBI-2817707;
CC Q9BYV2; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-2130429, EBI-739879;
CC Q9BYV2; Q9H257: CARD9; NbExp=3; IntAct=EBI-2130429, EBI-751319;
CC Q9BYV2; Q9HC52: CBX8; NbExp=3; IntAct=EBI-2130429, EBI-712912;
CC Q9BYV2; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-2130429, EBI-10171570;
CC Q9BYV2; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-2130429, EBI-10749669;
CC Q9BYV2; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-2130429, EBI-10247802;
CC Q9BYV2; Q7Z6N9: CCDC28A; NbExp=3; IntAct=EBI-2130429, EBI-10258115;
CC Q9BYV2; Q8IWP9: CCDC28A; NbExp=3; IntAct=EBI-2130429, EBI-355471;
CC Q9BYV2; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-2130429, EBI-749261;
CC Q9BYV2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-2130429, EBI-10175300;
CC Q9BYV2; Q16543: CDC37; NbExp=3; IntAct=EBI-2130429, EBI-295634;
CC Q9BYV2; Q07002: CDK18; NbExp=3; IntAct=EBI-2130429, EBI-746238;
CC Q9BYV2; P38936: CDKN1A; NbExp=6; IntAct=EBI-2130429, EBI-375077;
CC Q9BYV2; A8MT69: CENPX; NbExp=3; IntAct=EBI-2130429, EBI-5529694;
CC Q9BYV2; A8MT69-2: CENPX; NbExp=3; IntAct=EBI-2130429, EBI-13128870;
CC Q9BYV2; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-2130429, EBI-10181988;
CC Q9BYV2; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-2130429, EBI-749051;
CC Q9BYV2; Q96M91: CFAP53; NbExp=3; IntAct=EBI-2130429, EBI-742422;
CC Q9BYV2; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-2130429, EBI-2321769;
CC Q9BYV2; O14647-3: CHD2; NbExp=3; IntAct=EBI-2130429, EBI-11985957;
CC Q9BYV2; Q8IY22-3: CMIP; NbExp=3; IntAct=EBI-2130429, EBI-12149877;
CC Q9BYV2; P78560: CRADD; NbExp=3; IntAct=EBI-2130429, EBI-520375;
CC Q9BYV2; P67870: CSNK2B; NbExp=3; IntAct=EBI-2130429, EBI-348169;
CC Q9BYV2; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-2130429, EBI-11962928;
CC Q9BYV2; Q2TBE0: CWF19L2; NbExp=6; IntAct=EBI-2130429, EBI-5453285;
CC Q9BYV2; Q8WWE8: CYTH4; NbExp=3; IntAct=EBI-2130429, EBI-10277443;
CC Q9BYV2; Q5TAQ9: DCAF8; NbExp=2; IntAct=EBI-2130429, EBI-740686;
CC Q9BYV2; Q96GG9: DCUN1D1; NbExp=3; IntAct=EBI-2130429, EBI-740086;
CC Q9BYV2; P26196: DDX6; NbExp=3; IntAct=EBI-2130429, EBI-351257;
CC Q9BYV2; Q05D60: DEUP1; NbExp=6; IntAct=EBI-2130429, EBI-748597;
CC Q9BYV2; O96015: DNAL4; NbExp=3; IntAct=EBI-2130429, EBI-742362;
CC Q9BYV2; O60941-5: DTNB; NbExp=3; IntAct=EBI-2130429, EBI-11984733;
CC Q9BYV2; Q86UW9: DTX2; NbExp=9; IntAct=EBI-2130429, EBI-740376;
CC Q9BYV2; Q96EX3: DYNC2I2; NbExp=3; IntAct=EBI-2130429, EBI-2556091;
CC Q9BYV2; Q08426: EHHADH; NbExp=3; IntAct=EBI-2130429, EBI-2339219;
CC Q9BYV2; O60573: EIF4E2; NbExp=3; IntAct=EBI-2130429, EBI-398610;
CC Q9BYV2; Q92556: ELMO1; NbExp=3; IntAct=EBI-2130429, EBI-346417;
CC Q9BYV2; Q14241: ELOA; NbExp=3; IntAct=EBI-2130429, EBI-742350;
CC Q9BYV2; Q9H0I2: ENKD1; NbExp=6; IntAct=EBI-2130429, EBI-744099;
CC Q9BYV2; Q7L775: EPM2AIP1; NbExp=6; IntAct=EBI-2130429, EBI-6255981;
CC Q9BYV2; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-2130429, EBI-6251402;
CC Q9BYV2; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-2130429, EBI-742102;
CC Q9BYV2; Q9NQT4: EXOSC5; NbExp=6; IntAct=EBI-2130429, EBI-371876;
CC Q9BYV2; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-2130429, EBI-1752811;
CC Q9BYV2; Q86V42: FAM124A; NbExp=3; IntAct=EBI-2130429, EBI-744506;
CC Q9BYV2; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-2130429, EBI-741626;
CC Q9BYV2; Q3B820: FAM161A; NbExp=6; IntAct=EBI-2130429, EBI-719941;
CC Q9BYV2; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-2130429, EBI-742802;
CC Q9BYV2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-2130429, EBI-6658203;
CC Q9BYV2; O95363: FARS2; NbExp=3; IntAct=EBI-2130429, EBI-2513774;
CC Q9BYV2; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-2130429, EBI-10244131;
CC Q9BYV2; Q8IX29: FBXO16; NbExp=3; IntAct=EBI-2130429, EBI-12063229;
CC Q9BYV2; Q9UKT8: FBXW2; NbExp=2; IntAct=EBI-2130429, EBI-914727;
CC Q9BYV2; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-2130429, EBI-10172181;
CC Q9BYV2; O95995: GAS8; NbExp=3; IntAct=EBI-2130429, EBI-1052570;
CC Q9BYV2; P55040: GEM; NbExp=3; IntAct=EBI-2130429, EBI-744104;
CC Q9BYV2; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-2130429, EBI-11427343;
CC Q9BYV2; Q9NVN8: GNL3L; NbExp=3; IntAct=EBI-2130429, EBI-746682;
CC Q9BYV2; P78347-2: GTF2I; NbExp=3; IntAct=EBI-2130429, EBI-12033200;
CC Q9BYV2; Q86UP8: GTF2IRD2; NbExp=3; IntAct=EBI-2130429, EBI-6425928;
CC Q9BYV2; Q6EKJ0: GTF2IRD2B; NbExp=3; IntAct=EBI-2130429, EBI-12338155;
CC Q9BYV2; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-2130429, EBI-2514791;
CC Q9BYV2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-2130429, EBI-14103818;
CC Q9BYV2; Q969S8: HDAC10; NbExp=2; IntAct=EBI-2130429, EBI-301762;
CC Q9BYV2; O14964: HGS; NbExp=3; IntAct=EBI-2130429, EBI-740220;
CC Q9BYV2; P09067: HOXB5; NbExp=3; IntAct=EBI-2130429, EBI-3893317;
CC Q9BYV2; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-2130429, EBI-10263367;
CC Q9BYV2; Q15735: INPP5J; NbExp=6; IntAct=EBI-2130429, EBI-10236940;
CC Q9BYV2; Q8NA54: IQUB; NbExp=4; IntAct=EBI-2130429, EBI-10220600;
CC Q9BYV2; P27987: ITPKB; NbExp=3; IntAct=EBI-2130429, EBI-751388;
CC Q9BYV2; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-2130429, EBI-2556193;
CC Q9BYV2; Q9H8E8: KAT14; NbExp=3; IntAct=EBI-2130429, EBI-750907;
CC Q9BYV2; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-2130429, EBI-8472129;
CC Q9BYV2; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-2130429, EBI-2125614;
CC Q9BYV2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-2130429, EBI-14069005;
CC Q9BYV2; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-2130429, EBI-6426443;
CC Q9BYV2; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-2130429, EBI-739890;
CC Q9BYV2; P52292: KPNA2; NbExp=3; IntAct=EBI-2130429, EBI-349938;
CC Q9BYV2; P04264: KRT1; NbExp=3; IntAct=EBI-2130429, EBI-298429;
CC Q9BYV2; P12035: KRT3; NbExp=3; IntAct=EBI-2130429, EBI-2430095;
CC Q9BYV2; P19013: KRT4; NbExp=4; IntAct=EBI-2130429, EBI-2371606;
CC Q9BYV2; P02538: KRT6A; NbExp=11; IntAct=EBI-2130429, EBI-702198;
CC Q9BYV2; P04259: KRT6B; NbExp=6; IntAct=EBI-2130429, EBI-740907;
CC Q9BYV2; P48668: KRT6C; NbExp=6; IntAct=EBI-2130429, EBI-2564105;
CC Q9BYV2; O95678: KRT75; NbExp=3; IntAct=EBI-2130429, EBI-2949715;
CC Q9BYV2; Q01546: KRT76; NbExp=3; IntAct=EBI-2130429, EBI-2952745;
CC Q9BYV2; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-2130429, EBI-1056564;
CC Q9BYV2; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-2130429, EBI-2514135;
CC Q9BYV2; Q96BZ8: LENG1; NbExp=6; IntAct=EBI-2130429, EBI-726510;
CC Q9BYV2; Q96GY3: LIN37; NbExp=3; IntAct=EBI-2130429, EBI-748884;
CC Q9BYV2; P25800: LMO1; NbExp=3; IntAct=EBI-2130429, EBI-8639312;
CC Q9BYV2; P25791: LMO2; NbExp=3; IntAct=EBI-2130429, EBI-739696;
CC Q9BYV2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-2130429, EBI-11742507;
CC Q9BYV2; P61968: LMO4; NbExp=3; IntAct=EBI-2130429, EBI-2798728;
CC Q9BYV2; Q8TBB1: LNX1; NbExp=7; IntAct=EBI-2130429, EBI-739832;
CC Q9BYV2; Q9Y333: LSM2; NbExp=3; IntAct=EBI-2130429, EBI-347416;
CC Q9BYV2; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-2130429, EBI-77889;
CC Q9BYV2; O95983: MBD3; NbExp=3; IntAct=EBI-2130429, EBI-1783068;
CC Q9BYV2; O95983-2: MBD3; NbExp=3; IntAct=EBI-2130429, EBI-11978579;
CC Q9BYV2; P33993: MCM7; NbExp=3; IntAct=EBI-2130429, EBI-355924;
CC Q9BYV2; Q9HAF1: MEAF6; NbExp=3; IntAct=EBI-2130429, EBI-399266;
CC Q9BYV2; P55081: MFAP1; NbExp=6; IntAct=EBI-2130429, EBI-1048159;
CC Q9BYV2; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-2130429, EBI-10172526;
CC Q9BYV2; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-2130429, EBI-742459;
CC Q9BYV2; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-2130429, EBI-743811;
CC Q9BYV2; Q9H1R3: MYLK2; NbExp=2; IntAct=EBI-2130429, EBI-356910;
CC Q9BYV2; Q9ULV0: MYO5B; NbExp=3; IntAct=EBI-2130429, EBI-311356;
CC Q9BYV2; Q9ULV0-2: MYO5B; NbExp=3; IntAct=EBI-2130429, EBI-14093244;
CC Q9BYV2; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-2130429, EBI-11750983;
CC Q9BYV2; Q96IV0: NGLY1; NbExp=7; IntAct=EBI-2130429, EBI-6165879;
CC Q9BYV2; Q96HA8: NTAQ1; NbExp=6; IntAct=EBI-2130429, EBI-741158;
CC Q9BYV2; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-2130429, EBI-9057006;
CC Q9BYV2; Q92882: OSTF1; NbExp=3; IntAct=EBI-2130429, EBI-1051152;
CC Q9BYV2; Q96DC9: OTUB2; NbExp=4; IntAct=EBI-2130429, EBI-746259;
CC Q9BYV2; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-2130429, EBI-3921217;
CC Q9BYV2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-2130429, EBI-79165;
CC Q9BYV2; Q8N381: PIK3R3; NbExp=3; IntAct=EBI-2130429, EBI-749096;
CC Q9BYV2; O00444: PLK4; NbExp=3; IntAct=EBI-2130429, EBI-746202;
CC Q9BYV2; Q6NYC8: PPP1R18; NbExp=6; IntAct=EBI-2130429, EBI-2557469;
CC Q9BYV2; O43741: PRKAB2; NbExp=3; IntAct=EBI-2130429, EBI-1053424;
CC Q9BYV2; Q99633: PRPF18; NbExp=3; IntAct=EBI-2130429, EBI-2798416;
CC Q9BYV2; P0CG20: PRR35; NbExp=3; IntAct=EBI-2130429, EBI-11986293;
CC Q9BYV2; P25786: PSMA1; NbExp=3; IntAct=EBI-2130429, EBI-359352;
CC Q9BYV2; Q9UJ41: RABGEF1; NbExp=3; IntAct=EBI-2130429, EBI-913954;
CC Q9BYV2; Q9UJ41-4: RABGEF1; NbExp=3; IntAct=EBI-2130429, EBI-14093916;
CC Q9BYV2; P54725: RAD23A; NbExp=3; IntAct=EBI-2130429, EBI-746453;
CC Q9BYV2; A6NK89: RASSF10; NbExp=3; IntAct=EBI-2130429, EBI-6912267;
CC Q9BYV2; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-2130429, EBI-740773;
CC Q9BYV2; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-2130429, EBI-743428;
CC Q9BYV2; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-2130429, EBI-1504830;
CC Q9BYV2; P78317: RNF4; NbExp=3; IntAct=EBI-2130429, EBI-2340927;
CC Q9BYV2; Q7L4I2-2: RSRC2; NbExp=3; IntAct=EBI-2130429, EBI-10256202;
CC Q9BYV2; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-2130429, EBI-11984663;
CC Q9BYV2; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-2130429, EBI-748391;
CC Q9BYV2; O00560: SDCBP; NbExp=6; IntAct=EBI-2130429, EBI-727004;
CC Q9BYV2; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-2130429, EBI-10320311;
CC Q9BYV2; O14796: SH2D1B; NbExp=6; IntAct=EBI-2130429, EBI-3923013;
CC Q9BYV2; Q92529: SHC3; NbExp=3; IntAct=EBI-2130429, EBI-79084;
CC Q9BYV2; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-2130429, EBI-358489;
CC Q9BYV2; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-2130429, EBI-455078;
CC Q9BYV2; Q96H20: SNF8; NbExp=6; IntAct=EBI-2130429, EBI-747719;
CC Q9BYV2; Q9NZD8: SPG21; NbExp=6; IntAct=EBI-2130429, EBI-742688;
CC Q9BYV2; Q9H741: SPRING1; NbExp=3; IntAct=EBI-2130429, EBI-2836158;
CC Q9BYV2; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-2130429, EBI-12029182;
CC Q9BYV2; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-2130429, EBI-2212028;
CC Q9BYV2; Q9NU19: TBC1D22B; NbExp=5; IntAct=EBI-2130429, EBI-8787464;
CC Q9BYV2; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-2130429, EBI-11974855;
CC Q9BYV2; Q15560: TCEA2; NbExp=6; IntAct=EBI-2130429, EBI-710310;
CC Q9BYV2; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-2130429, EBI-11955057;
CC Q9BYV2; Q9BT92: TCHP; NbExp=3; IntAct=EBI-2130429, EBI-740781;
CC Q9BYV2; Q15561: TEAD4; NbExp=3; IntAct=EBI-2130429, EBI-747736;
CC Q9BYV2; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-2130429, EBI-11139477;
CC Q9BYV2; Q96FV9: THOC1; NbExp=3; IntAct=EBI-2130429, EBI-1765605;
CC Q9BYV2; Q5JTD0: TJAP1; NbExp=3; IntAct=EBI-2130429, EBI-2814077;
CC Q9BYV2; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-2130429, EBI-11059915;
CC Q9BYV2; Q99816: TSG101; NbExp=3; IntAct=EBI-2130429, EBI-346882;
CC Q9BYV2; Q63HK5: TSHZ3; NbExp=6; IntAct=EBI-2130429, EBI-9053916;
CC Q9BYV2; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-2130429, EBI-3918381;
CC Q9BYV2; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-2130429, EBI-6447954;
CC Q9BYV2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-2130429, EBI-9090990;
CC Q9BYV2; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-2130429, EBI-2851213;
CC Q9BYV2; P51668: UBE2D1; NbExp=3; IntAct=EBI-2130429, EBI-743540;
CC Q9BYV2; P62837: UBE2D2; NbExp=3; IntAct=EBI-2130429, EBI-347677;
CC Q9BYV2; Q9Y2X8: UBE2D4; NbExp=3; IntAct=EBI-2130429, EBI-745527;
CC Q9BYV2; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-2130429, EBI-10180829;
CC Q9BYV2; P11441: UBL4A; NbExp=3; IntAct=EBI-2130429, EBI-356983;
CC Q9BYV2; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-2130429, EBI-739895;
CC Q9BYV2; Q08E77: UTP14C; NbExp=3; IntAct=EBI-2130429, EBI-10225961;
CC Q9BYV2; Q548N1: VPS28; NbExp=3; IntAct=EBI-2130429, EBI-10243107;
CC Q9BYV2; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-2130429, EBI-9031083;
CC Q9BYV2; Q6GPH4: XAF1; NbExp=6; IntAct=EBI-2130429, EBI-2815120;
CC Q9BYV2; Q05516: ZBTB16; NbExp=6; IntAct=EBI-2130429, EBI-711925;
CC Q9BYV2; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-2130429, EBI-10237226;
CC Q9BYV2; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-2130429, EBI-3439227;
CC Q9BYV2; P15622-3: ZNF250; NbExp=6; IntAct=EBI-2130429, EBI-10177272;
CC Q9BYV2; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-2130429, EBI-740727;
CC Q9BYV2; Q7Z3I7: ZNF572; NbExp=9; IntAct=EBI-2130429, EBI-10172590;
CC Q9BYV2; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-2130429, EBI-6427977;
CC Q9BYV2; A8K2R3; NbExp=3; IntAct=EBI-2130429, EBI-9977437;
CC Q9BYV2; Q9BRL5; NbExp=3; IntAct=EBI-2130429, EBI-10296986;
CC Q9BYV2; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-2130429, EBI-25492395;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC myofibril, sarcomere, Z line {ECO:0000250}. Note=Associates with
CC microtubules. Localizes to the Z-lines in skeletal muscles (By
CC similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BYV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BYV2-2; Sequence=VSP_016061;
CC -!- TISSUE SPECIFICITY: Specifically expressed in heart and skeletal
CC muscle. {ECO:0000269|PubMed:11243782}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY24296.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC32841.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC32842.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ291714; CAC32841.1; ALT_INIT; mRNA.
DR EMBL; AJ291714; CAC32842.1; ALT_INIT; mRNA.
DR EMBL; AC013413; AAY24296.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471053; EAX00606.1; -; Genomic_DNA.
DR EMBL; BC141807; AAI41808.1; -; mRNA.
DR CCDS; CCDS1745.2; -. [Q9BYV2-2]
DR CCDS; CCDS1746.2; -. [Q9BYV2-1]
DR RefSeq; NP_115935.3; NM_032546.3. [Q9BYV2-2]
DR RefSeq; NP_912730.2; NM_187841.2. [Q9BYV2-1]
DR PDB; 3Q1D; X-ray; 2.15 A; A=122-168.
DR PDBsum; 3Q1D; -.
DR AlphaFoldDB; Q9BYV2; -.
DR SMR; Q9BYV2; -.
DR BioGRID; 121415; 319.
DR IntAct; Q9BYV2; 338.
DR iPTMnet; Q9BYV2; -.
DR PhosphoSitePlus; Q9BYV2; -.
DR BioMuta; TRIM54; -.
DR DMDM; 209572715; -.
DR EPD; Q9BYV2; -.
DR MassIVE; Q9BYV2; -.
DR MaxQB; Q9BYV2; -.
DR PeptideAtlas; Q9BYV2; -.
DR PRIDE; Q9BYV2; -.
DR ProteomicsDB; 79712; -. [Q9BYV2-1]
DR ProteomicsDB; 79713; -. [Q9BYV2-2]
DR Antibodypedia; 13583; 381 antibodies from 32 providers.
DR DNASU; 57159; -.
DR Ensembl; ENST00000296098.4; ENSP00000296098.4; ENSG00000138100.14. [Q9BYV2-2]
DR Ensembl; ENST00000380075.7; ENSP00000369415.3; ENSG00000138100.14. [Q9BYV2-1]
DR GeneID; 57159; -.
DR KEGG; hsa:57159; -.
DR MANE-Select; ENST00000380075.7; ENSP00000369415.3; NM_187841.3; NP_912730.2.
DR UCSC; uc002rjn.4; human. [Q9BYV2-1]
DR CTD; 57159; -.
DR DisGeNET; 57159; -.
DR GeneCards; TRIM54; -.
DR HGNC; HGNC:16008; TRIM54.
DR HPA; ENSG00000138100; Group enriched (heart muscle, skeletal muscle, tongue).
DR MIM; 606474; gene.
DR neXtProt; NX_Q9BYV2; -.
DR OpenTargets; ENSG00000138100; -.
DR PharmGKB; PA34434; -.
DR VEuPathDB; HostDB:ENSG00000138100; -.
DR GeneTree; ENSGT00940000154004; -.
DR HOGENOM; CLU_013137_5_1_1; -.
DR InParanoid; Q9BYV2; -.
DR OMA; DAHSMDS; -.
DR OrthoDB; 824972at2759; -.
DR PhylomeDB; Q9BYV2; -.
DR TreeFam; TF331669; -.
DR PathwayCommons; Q9BYV2; -.
DR SignaLink; Q9BYV2; -.
DR BioGRID-ORCS; 57159; 10 hits in 1104 CRISPR screens.
DR ChiTaRS; TRIM54; human.
DR EvolutionaryTrace; Q9BYV2; -.
DR GenomeRNAi; 57159; -.
DR Pharos; Q9BYV2; Tbio.
DR PRO; PR:Q9BYV2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9BYV2; protein.
DR Bgee; ENSG00000138100; Expressed in apex of heart and 100 other tissues.
DR Genevisible; Q9BYV2; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; NAS:UniProtKB.
DR GO; GO:0005875; C:microtubule associated complex; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007017; P:microtubule-based process; NAS:UniProtKB.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; NAS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR CDD; cd16761; RING-HC_MuRF3; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR033492; TRIM54/TRIM55.
DR InterPro; IPR042752; TRIM54_RING-HC.
DR InterPro; IPR027370; Znf-RING_LisH.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103:SF596; PTHR24103:SF596; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Developmental protein; Differentiation; Metal-binding; Microtubule;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..358
FT /note="Tripartite motif-containing protein 54"
FT /id="PRO_0000056282"
FT DOMAIN 271..329
FT /note="COS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00586"
FT ZN_FING 26..82
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 121..163
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 168..211
FT /note="Mediates microtubule-binding and
FT homooligomerization"
FT /evidence="ECO:0000250"
FT REGION 326..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 220..258
FT /evidence="ECO:0000255"
FT BINDING 126
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 129
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 149
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 155
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT VAR_SEQ 171
FT /note="K -> KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11243782"
FT /id="VSP_016061"
FT CONFLICT 172
FT /note="S -> N (in Ref. 1; CAC32841)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="N -> T (in Ref. 1; CAC32841/CAC32842)"
FT /evidence="ECO:0000305"
FT STRAND 127..129
FT /evidence="ECO:0007829|PDB:3Q1D"
FT STRAND 132..138
FT /evidence="ECO:0007829|PDB:3Q1D"
FT TURN 139..142
FT /evidence="ECO:0007829|PDB:3Q1D"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:3Q1D"
FT HELIX 147..151
FT /evidence="ECO:0007829|PDB:3Q1D"
FT TURN 154..157
FT /evidence="ECO:0007829|PDB:3Q1D"
FT STRAND 160..162
FT /evidence="ECO:0007829|PDB:3Q1D"
FT HELIX 164..166
FT /evidence="ECO:0007829|PDB:3Q1D"
SQ SEQUENCE 358 AA; 40301 MW; C44B08A9871323F6 CRC64;
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP
LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA
EQHLMCEEHE EEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM
LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE
EKLQRVRGLI RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP EEERPDGP
