ID   TRI54_PONAB             Reviewed;         358 AA.
AC   Q5REJ9;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Tripartite motif-containing protein 54;
GN   Name=TRIM54;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind and stabilize microtubules during myotubes
CC       formation. {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer and heterooligomer. Interacts with TRIM63 and
CC       probably with TRIM55. Interacts with tubulin (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       myofibril, sarcomere, Z line {ECO:0000250}. Note=Associates with
CC       microtubules. Localizes to the Z-lines in skeletal muscles (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; CR857526; CAH89808.1; -; mRNA.
DR   RefSeq; NP_001124836.1; NM_001131364.1.
DR   AlphaFoldDB; Q5REJ9; -.
DR   SMR; Q5REJ9; -.
DR   STRING; 9601.ENSPPYP00000014021; -.
DR   Ensembl; ENSPPYT00000062312; ENSPPYP00000026265; ENSPPYG00000031097.
DR   GeneID; 100171694; -.
DR   KEGG; pon:100171694; -.
DR   CTD; 57159; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000154004; -.
DR   InParanoid; Q5REJ9; -.
DR   Proteomes; UP000001595; Chromosome 2A.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   CDD; cd16761; RING-HC_MuRF3; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017903; COS_domain.
DR   InterPro; IPR033492; TRIM54/TRIM55.
DR   InterPro; IPR042752; TRIM54_RING-HC.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR24103:SF596; PTHR24103:SF596; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51262; COS; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Differentiation; Metal-binding; Microtubule; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..358
FT                   /note="Tripartite motif-containing protein 54"
FT                   /id="PRO_0000056284"
FT   DOMAIN          271..329
FT                   /note="COS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00586"
FT   ZN_FING         26..82
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         121..163
FT                   /note="B box-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   REGION          168..211
FT                   /note="Mediates microtubule-binding and
FT                   homooligomerization"
FT                   /evidence="ECO:0000250"
FT   REGION          326..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          194..258
FT                   /evidence="ECO:0000255"
FT   BINDING         126
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         129
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         149
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         155
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ   SEQUENCE   358 AA;  40263 MW;  801A5DB8D12130C3 CRC64;
     MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP
     LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA
     EQHLMCEEHE EEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM
     LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE
     EKLQRVRGLI RQYGDHLEAS SKLVETAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
     RPEPGYESME QFTVSVEHVA EMLRTIDFQP GASGEEEEVA PDGDEGSAGQ EEERPDGP