ID   TRI59_CHICK             Reviewed;         408 AA.
AC   Q5ZMD4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Tripartite motif-containing protein 59;
GN   Name=TRIM59; ORFNames=RCJMB04_2h17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May serve as a multifunctional regulator for innate immune
CC       signaling pathways. {ECO:0000250|UniProtKB:Q922Y2}.
CC   -!- SUBUNIT: Interacts with ECSIT. {ECO:0000250|UniProtKB:Q922Y2}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q922Y2}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR   EMBL; AJ719450; CAG31109.1; -; mRNA.
DR   RefSeq; NP_001026491.1; NM_001031320.1.
DR   AlphaFoldDB; Q5ZMD4; -.
DR   SMR; Q5ZMD4; -.
DR   STRING; 9031.ENSGALP00000038403; -.
DR   PaxDb; Q5ZMD4; -.
DR   PRIDE; Q5ZMD4; -.
DR   GeneID; 425013; -.
DR   KEGG; gga:425013; -.
DR   CTD; 286827; -.
DR   VEuPathDB; HostDB:geneid_425013; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   InParanoid; Q5ZMD4; -.
DR   OrthoDB; 635534at2759; -.
DR   PhylomeDB; Q5ZMD4; -.
DR   PRO; PR:Q5ZMD4; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..408
FT                   /note="Tripartite motif-containing protein 59"
FT                   /id="PRO_0000249681"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         10..60
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         92..134
FT                   /note="B box-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   COILED          163..247
FT                   /evidence="ECO:0000255"
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         120
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         126
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ   SEQUENCE   408 AA;  46775 MW;  AE86340E0601FC44 CRC64;
     MHQFEEELTC SICYSLFEDP RVLPCSHTFC RSCLEGVIQL SSNFSIWRPL RVPLKCPNCR
     SIVEIPASGT ESLPINFALK AIIEKYRQED HSDVATCSEH YRQPLNVYCL LDKKLVCGHC
     LTIGKHNGHP IDDLHSAYLK EKESSGKILE QLTDKHWSDV CLLIEKLKEQ KAQCESIVQD
     DKKVVVQYFK KLSETLEHKK QVLLAALDEI NRQILEEYEP HIEKLKKIRE EQLELMSLNT
     SIQKEESPLV FLEKVDNVHQ RIKALKEKEL PDVKPVEVYP RVGHLLKDVW SKTEIGQINK
     ILTPKIKLVP KRKLHSKNSE KERGKPEELL QAANPLSVTF IFTVIIAIAV LSFHKPISSV
     VIESIPTHIS DFFGFLYQDF CTCMQNTVDV VCHKLNSLAE FLGGIVPF