TRI60_HUMAN
ID TRI60_HUMAN Reviewed; 471 AA.
AC Q495X7; Q8NA35;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tripartite motif-containing protein 60;
DE AltName: Full=RING finger protein 129;
DE AltName: Full=RING finger protein 33;
GN Name=TRIM60; Synonyms=RNF129, RNF33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q495X7; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-13576620, EBI-739832;
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AK093201; BAC04093.1; -; mRNA.
DR EMBL; BC100983; AAI00984.1; -; mRNA.
DR EMBL; BC100984; AAI00985.1; -; mRNA.
DR EMBL; BC100985; AAI00986.1; -; mRNA.
DR EMBL; BC100986; AAI00987.1; -; mRNA.
DR CCDS; CCDS3808.1; -.
DR RefSeq; NP_001244954.1; NM_001258025.1.
DR RefSeq; NP_689833.1; NM_152620.2.
DR RefSeq; XP_011529985.1; XM_011531683.2.
DR AlphaFoldDB; Q495X7; -.
DR SMR; Q495X7; -.
DR BioGRID; 127931; 5.
DR IntAct; Q495X7; 1.
DR STRING; 9606.ENSP00000421142; -.
DR iPTMnet; Q495X7; -.
DR PhosphoSitePlus; Q495X7; -.
DR SwissPalm; Q495X7; -.
DR BioMuta; TRIM60; -.
DR DMDM; 114154820; -.
DR MassIVE; Q495X7; -.
DR PaxDb; Q495X7; -.
DR PeptideAtlas; Q495X7; -.
DR PRIDE; Q495X7; -.
DR Antibodypedia; 28289; 47 antibodies from 14 providers.
DR DNASU; 166655; -.
DR Ensembl; ENST00000341062.6; ENSP00000343765.5; ENSG00000176979.14.
DR Ensembl; ENST00000508504.1; ENSP00000426496.1; ENSG00000176979.14.
DR Ensembl; ENST00000512596.6; ENSP00000421142.1; ENSG00000176979.14.
DR Ensembl; ENST00000647760.1; ENSP00000497401.1; ENSG00000176979.14.
DR GeneID; 166655; -.
DR KEGG; hsa:166655; -.
DR MANE-Select; ENST00000512596.6; ENSP00000421142.1; NM_152620.3; NP_689833.1.
DR UCSC; uc003iqy.2; human.
DR CTD; 166655; -.
DR DisGeNET; 166655; -.
DR GeneCards; TRIM60; -.
DR HGNC; HGNC:21162; TRIM60.
DR HPA; ENSG00000176979; Group enriched (placenta, testis).
DR MIM; 619416; gene.
DR neXtProt; NX_Q495X7; -.
DR OpenTargets; ENSG00000176979; -.
DR PharmGKB; PA134909634; -.
DR VEuPathDB; HostDB:ENSG00000176979; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000155329; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; Q495X7; -.
DR OMA; CYNPRRF; -.
DR OrthoDB; 423686at2759; -.
DR PhylomeDB; Q495X7; -.
DR TreeFam; TF338674; -.
DR PathwayCommons; Q495X7; -.
DR SignaLink; Q495X7; -.
DR BioGRID-ORCS; 166655; 11 hits in 1102 CRISPR screens.
DR ChiTaRS; TRIM60; human.
DR GenomeRNAi; 166655; -.
DR Pharos; Q495X7; Tdark.
DR PRO; PR:Q495X7; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q495X7; protein.
DR Bgee; ENSG00000176979; Expressed in placenta and 5 other tissues.
DR ExpressionAtlas; Q495X7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd15828; SPRY_PRY_TRIM60; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR035786; SPRY/PRY_TRIM60.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..471
FT /note="Tripartite motif-containing protein 60"
FT /id="PRO_0000249189"
FT DOMAIN 277..470
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 16..57
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 92..133
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 171..223
FT /evidence="ECO:0000255"
FT BINDING 97
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 100
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 119
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 125
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT CONFLICT 445
FT /note="T -> I (in Ref. 2; AAI00986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 471 AA; 55114 MW; 6E1E8986BBFC9238 CRC64;
MEFVTALVNL QEESSCPICL EYLKDPVTIN CGHNFCRSCL SVSWKDLDDT FPCPVCRFCF
PYKSFRRNPQ LRNLTEIAKQ LQIRRSKRKR QKENAMCEKH NQFLTLFCVK DLEILCTQCS
FSTKHQKHYI CPIKKAASYH REILEGSLEP LRNNIERVEK VIILQGSKSV ELKKKVEYKR
EEINSEFEQI RLFLQNEQEM ILRQIQDEEM NILAKLNENL VELSDYVSTL KHLLREVEGK
SVQSNLELLT QAKSMHHKYQ NLKCPELFSF RLTKYGFSLP PQYSGLDRII KPFQVDVILD
LNTAHPQLLV SEDRKAVRYE RKKRNICYDP RRFYVCPAVL GSQRFSSGRH YWEVEVGNKP
KWILGVCQDC LLRNWQDQPS VLGGFWAIGR YMKSGYVASG PKTTQLLPVV KPSKIGIFLD
YELGDLSFYN MNDRSILYTF NDCFTEAVWP YFYTGTDSEP LKICSVSDSE R
