ID   TRI61_HUMAN             Reviewed;         209 AA.
AC   Q5EBN2;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Putative tripartite motif-containing protein 61;
DE   AltName: Full=RING finger protein 35;
GN   Name=TRIM61; Synonyms=RNF35;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC089393; AAH89393.1; -; mRNA.
DR   CCDS; CCDS34093.1; -.
DR   RefSeq; NP_001012414.1; NM_001012414.2.
DR   AlphaFoldDB; Q5EBN2; -.
DR   SMR; Q5EBN2; -.
DR   BioGRID; 134027; 11.
DR   STRING; 9606.ENSP00000332288; -.
DR   BioMuta; TRIM61; -.
DR   DMDM; 74741447; -.
DR   PaxDb; Q5EBN2; -.
DR   PeptideAtlas; Q5EBN2; -.
DR   PRIDE; Q5EBN2; -.
DR   Antibodypedia; 28285; 49 antibodies from 7 providers.
DR   DNASU; 391712; -.
DR   Ensembl; ENST00000329314.6; ENSP00000332288.5; ENSG00000183439.9.
DR   GeneID; 391712; -.
DR   KEGG; hsa:391712; -.
DR   MANE-Select; ENST00000329314.6; ENSP00000332288.5; NM_001012414.3; NP_001012414.1.
DR   UCSC; uc003iqw.4; human.
DR   CTD; 391712; -.
DR   GeneCards; TRIM61; -.
DR   HGNC; HGNC:24339; TRIM61.
DR   HPA; ENSG00000183439; Low tissue specificity.
DR   MIM; 619417; gene.
DR   neXtProt; NX_Q5EBN2; -.
DR   OpenTargets; ENSG00000183439; -.
DR   PharmGKB; PA134868214; -.
DR   VEuPathDB; HostDB:ENSG00000183439; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000155329; -.
DR   HOGENOM; CLU_013137_6_4_1; -.
DR   InParanoid; Q5EBN2; -.
DR   OrthoDB; 1386851at2759; -.
DR   PhylomeDB; Q5EBN2; -.
DR   PathwayCommons; Q5EBN2; -.
DR   SignaLink; Q5EBN2; -.
DR   BioGRID-ORCS; 391712; 55 hits in 1068 CRISPR screens.
DR   ChiTaRS; TRIM61; human.
DR   GenomeRNAi; 391712; -.
DR   Pharos; Q5EBN2; Tdark.
DR   PRO; PR:Q5EBN2; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q5EBN2; protein.
DR   Bgee; ENSG00000183439; Expressed in secondary oocyte and 135 other tissues.
DR   ExpressionAtlas; Q5EBN2; baseline and differential.
DR   Genevisible; Q5EBN2; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00643; zf-B_box; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..209
FT                   /note="Putative tripartite motif-containing protein 61"
FT                   /id="PRO_0000272303"
FT   ZN_FING         16..57
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         92..133
FT                   /note="B box-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         119
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         125
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ   SEQUENCE   209 AA;  24047 MW;  D8B4C4C36E7C6307 CRC64;
     MEFVTALADL RAEASCPICL DYLKDPVTIS CGHNFCLSCI IMSWKDLHDS FPCPFCHFCC
     PERKFISNPQ LGSLTEIAKQ LQIRSKKRKR QEEKHVCKKH NQVLTFFCQK DLELLCPRCS
     LSTDHQHHCV WPIKKAASYH RKKLEEYNAP WKERVELIEK VITMQTRKSL ELKKKMESPS
     VTRLECSCTI SAHFNLRLPG SSDSSASGS